PBT434 free base
Based on 2 publication(s) in Google Scholar
PBT434 (ATH434) free base is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 free base can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 free base inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 free base prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 free base has the potential for the research of Parkinson’s disease (PD).
For research use only. We do not sell to patients.
- CAS No.: 1232840-87-7
- Formula: C12H13Cl2N3O2
- Molecular Weight:302.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) PBT434 free base
MoreAll α-synuclein Isoforms
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Biological Activity
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α-synuclein Aggregation |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1232840-87-7
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Molecular Weight 302.16
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Formula C12H13Cl2N3O2
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SMILES
O=C1N(C)C(CNCC)=NC2=C1C(Cl)=CC(Cl)=C2O
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Synonyms
ATH434 free base
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Metallomics
2024 Oct 4;16(10):mfae044. PMID: 39317669 -
Purity & Documentation
References
[1]. Finkelstein DI, et al. The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease. Acta Neuropathol Commun. 2017 Jun 28;5(1):53. [Content Brief]
[2]. Bailey DK, et al. The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells. PLoS One. 2021 Jul 26;16(7):e0254794. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PBT434 free base Related Classifications
HY-120475B Related Classifications
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