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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
50 Results for "
PKC γ
" in MedChemExpress (MCE) Product Catalog:
Products (50)
50 Results for "PKC γ" in MCE Product Catalog:
Cat. No.: HY-108601A
CAS No.: 1781828-85-0
Target:
Research Areas:
(S)-Ro 32-0432 is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research .
Cat. No.: HY-121197
CAS No.: 63590-19-2
Synonyms: Ophiocordin; Azepinostatin
Category:
Cat. No.: HY-13867R
CAS No.: 133052-90-1
Synonyms: GF109203X (Standard); Go 6850 (Standard)
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Bisindolylmaleimide I (Standard) is the analytical standard of Bisindolylmaleimide I. This product is intended for research and analytical applications. Bisindolylmaleimide I (GF109203X) is a cell-permeable and reversible PKC inhibitor (IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I is also a GSK-3 inhibitor .
Cat. No.: HY-10230S
Purity: ≥98.0%
Synonyms: PKC412-d5; CGP 41251-d5
Cat. No.: HY-122967
CAS No.: 142115-17-1
Category:
Labiatae Phenols Polyphenols Plants Dolichos trilobus Houtt.
Research Areas:
HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis .
Cat. No.: HY-13689R
CAS No.: 133053-19-7
Synonyms: Gö 6983 (Standard); Goe 6983 (Standard)
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Go 6983 (Standard) is the analytical standard of Go 6983. This product is intended for research and analytical applications. Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
Cat. No.: HY-139466
CAS No.: 1072100-15-2
Research Areas:
PF-03622905 is a potent and ATP-competitive PKC inhibitor with IC50s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, respectively. PF-03622905 shows high specificity for PKC over other protein kinases .
Cat. No.: HY-139467
CAS No.: 1072100-81-2
Research Areas:
PF-04577806 is a potent, selective and ATP competitive PKC inhibitor. PF-04577806 shows potent inhibitory activity towards PKCα, PKCβI, PKCβII, PKCγ, and PKCθ with IC50s of 2.4 nM, 8.1 nM, 6.9 nM, 45.9 nM, and 29.5 nM, respectively. PF-04577806 can reverse retinal vascular leakage in diabetic rats .
Cat. No.: HY-141613A
CAS No.: 6811-55-8
Dioleyl phosphatidylserine is a phospholipid that can be used to form the cochlea. Dioleyl phosphatidylserine (100 μM) can activate PKC-γ under Ca 2+ concentrations < 0.5 μM .
Cat. No.: HY-10230R
CAS No.: 120685-11-2
Synonyms: PKC412 (Standard); CGP 41251 (Standard)
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Midostaurin (Standard) is the analytical standard of Midostaurin. This product is intended for research and analytical applications. Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .
Cat. No.: HY-10342R
CAS No.: 170364-57-5
Synonyms: LY317615 (Standard)
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Enzastaurin (Standard) is the analytical standard of Enzastaurin. This product is intended for research and analytical applications. Enzastaurin (LY317615) is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε .
Cat. No.: HY-B0719R
CAS No.: 75567-37-2
Synonyms: Ingenol 3-angelate (Standard); PEP005 (Standard)
Target:
Cat. No.: HY-13867AR
CAS No.: 176504-36-2
Synonyms: GF109203X hydrochloride (Standard); Go 6850 hydrochloride (Standard)
Target:
Research Areas:
Bisindolylmaleimide I (hydrochloride) (Standard) is the analytical standard of Bisindolylmaleimide I (hydrochloride). This product is intended for research and analytical applications. Bisindolylmaleimide I (GF109203X) hydrochloride is a cell-permeable and reversible PKC inhibitor (IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I hydrochloride is also a GSK-3 inhibitor .
Cat. No.: HY-129624
CAS No.: 125313-65-7
Synonyms: Ro 31-7549; Bis VIII
Research Areas:
Bisindolylmaleimide VIII (Ro 31-7549) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively . Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases .
Cat. No.: HY-108601
CAS No.: 151342-35-7
Target:
Research Areas:
(S)-Ro 32-0432 free base is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 free base for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 free base is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 free base prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research .
Cat. No.: HY-W751179
Synonyms: PKC412-13C6; CGP 41251-13C6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
