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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
315 Results for "
PTP
" in MedChemExpress (MCE) Product Catalog:
Products (315)
315 Results for "PTP" in MCE Product Catalog:
2
2 Cited Publications
Research Areas:
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor which can also inhibit several cytochrome P450 (P450) isoforms and lysine methyltransferase SETD8 (KMT5A).
2
2 Cited Publications
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KY-226 is a potent, selective, orally active and allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 0.25 μM, and without PPARγ agonist activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. KY-226 also protects neurons from cerebral ischemic injury .
1
1 Cited Publications
Cat. No.: HY-W013478
CAS No.: 2632-13-5
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PTP inhibitor 1 is a protein tyrosine phosphatase (PTP) inhibitor, with anti-angiogenic effect .
1
1 Cited Publications
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PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes .
1
1 Cited Publications
Cat. No.: HY-P5982
Research Areas:
1
1 Cited Publications
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PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM . PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively .
1
1 Cited Publications
Cat. No.: HY-P73685
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PTPN1; Protein-Tyrosine Phosphatase 1B; Prev. PTP1B; Protein Tyrosine Phosphatase, Placental; Tyrosine-Protein Phosphatase Non-Receptor Type 1; PTP-1B; Protein Tyrosine Phosphatase Non-Receptor Type 1; Tyrosine-Protein Phosphatase Non-Receptor Type
Species:
Human
Source:
E. coli
1
1 Cited Publications
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SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively .
1
1 Cited Publications
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MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC50 of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs) .
1
1 Cited Publications
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CPT-157633, a difluoro-phosphonomethyl phenylalanine derivative, and is a PTP1B inhibitor. CPT-157633 prevents binge drinking-induced glucose intolerance .
1
1 Cited Publications
Cat. No.: HY-N10002
CAS No.: 109163-69-1
Category:
Coffea canephora Pierre ex Froehn. Ketones, Aldehydes, Acids Rubiaceae Phenols Polyphenols Plants
Target:
1
1 Cited Publications
Synonyms: Oxophenylarsine; PhAsO; Arsenosobenzene
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Phenylarsine oxide (PAO), an inhibitor of endocytosis, inhibits PTPε with an IC50 of 18 μM. Phenylarsine oxide (PAO) inhibits oxygen consumption and decreases cellular ATP content overlap with those used to inhibit protein internalization .
1
1 Cited Publications
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MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC50 values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively . (A family of human MAPK-specific protein tyrosine phosphatases)
1
1 Cited Publications
Cat. No.: HY-P71141
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PTPN6; Protein-Tyrosine Phosphatase SHP-1; Protein Tyrosine Phosphatase Non-Receptor Type 6; Protein-Tyrosine Phosphatase 1C; PTP-1C; SH-PTP1; HCP; Tyrosine-Protein Phosphatase Non-Receptor Type; SHP-1; Hematopoietic Cell Phosphatase; HCPH; Protein-Tyrosi
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P700618
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PTPN11; Protein Tyrosine Phosphatase Non-Receptor Type 11 Isoform 1; Prev. NS1; Tyrosine-Protein Phosphatase Non-Receptor Type; SH-PTP2; Protein-Tyrosine-Phosphatase; PTP2C; Noonan Syndrome 1; BPTP3; CDNA, FLJ92431; SHP-2; PTPN11 Protein; SHP2; METCDS; SH
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-N0646
CAS No.: 29782-68-1
Cat. No.: HY-P5247
Synonyms: PTP20
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Synonyms: PTPN2/1-IN-1
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Research Areas:
Tegeprotafib (PTPN2/1-IN-1) (Compound 124) is an orally active PTPN1 and PTPN2 inhibitor with IC50s of 4.4 nM and 1-10 nM against PTPN2 and PTP1B, respectively .
Cat. No.: HY-164864
CAS No.: 3053413-58-1
DU-14 (PTP1B/TC-PTP PROTAC) is a potent and selective PTP1B and TC-PTP dual PROTAC degrader. DU-14 (PTP1B/TC-PTP PROTAC) has the IC50 for PTP1B and TC-PTP phosphatase activity of 24.2 nM and 30.1 nM, respectively. DU-14 (PTP1B/TC-PTP PROTAC) enhances IFN-γ signaling, promotes T cell activation, and has anti-tumor activity .
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PTP1B-IN-3 is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 has antidiabetic and anticancer effects .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
