637-03-6
637-03-6
Chemical Structure
Phenylarsine oxide
Synonym(s): Oxophenylarsine; PhAsO; Arsenosobenzene
- CAS No.: 637-03-6
- Formula:C6H5AsO
- Molecular Weight:168.02
IUPAC Name: oxo(phenyl)arsane
InChIKey: BQVCCPGCDUSGOE-UHFFFAOYSA-N
SMILES: O=[As]C1=CC=CC=C1
Biological Activity: Phenylarsine oxide (PAO), an inhibitor of endocytosis, inhibits PTPε with an IC50 of 18 μM. Phenylarsine oxide (PAO) inhibits oxygen consumption and decreases cellular ATP content overlap with those used to inhibit protein internalization[1][2].
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Phenylarsine oxide | 99.32% | Phenylarsine oxide (PAO), an inhibitor of endocytosis, inhibits PTPε with an IC50 of 18 μM. Phenylarsine oxide (PAO) inhibits oxygen consumption and decreases cellular ATP content overlap with those used to inhibit protein internalization. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-121641Nitrosobenzene -
Similarity Score 0.77
HY-W998834Phenol, potassium salt (4:1) -
Similarity Score 0.77
HY-Y0747Iodobenzene -
Similarity Score 0.77
HY-W035904Tropone -
Similarity Score 0.76
HY-B0892Benzyl alcohol -
Similarity Score 0.76
HY-B0892S3Benzyl alcohol-13C6 -
Similarity Score 0.76
HY-B0892S5Benzyl alcohol-13C -
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References
- [1]. A Schmidt, et al. Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3068-73. [Content Brief]
- [2]. A E Gibson, et al. Phenylarsine oxide inhibition of endocytosis: effects on asialofetuin internalization. Am J Physiol. 1989 Aug;257(2 Pt 1):C182-4. [Content Brief]
