809272-64-8
809272-64-8
Chemical Structure
PTP1B-IN-3
- CAS No.: 809272-64-8
- Formula:C12H7BrF2NO3P
- Molecular Weight:362.06
IUPAC Name: ((3-bromo-7-cyanonaphthalen-2-yl)difluoromethyl)phosphonic acid
InChIKey: BWJOQFMMTKEZGA-UHFFFAOYSA-N
SMILES: BrC1=C(C(F)(P(O)(O)=O)F)C=C2C(C=CC(C#N)=C2)=C1
Biological Activity: PTP1B-IN-3 is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 has antidiabetic and anticancer effects[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PTP1B-IN-3 | 99.69% | PTP1B-IN-3 is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 has antidiabetic and anticancer effects. | ||||||||||||||||||||
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References
- [1]. Yongxin Han, et al. Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3200-5. [Content Brief]
- [2]. Patel D, .Discovery of orally active, potent, and selective benzotriazole-based PTP1B inhibitors. ChemMedChem. 2011 Jun 6; 6(6):1011-6. [Content Brief]
