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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
47 Results for "
Synaptic plasticity
" in MedChemExpress (MCE) Product Catalog:
Products (47)
47 Results for "Synaptic plasticity" in MCE Product Catalog:
Cat. No.: HY-100808S
CAS No.: 1414348-52-9
Synonyms: (R)-Serine-d3
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
NYX-2925 is an orally active, blood-brain barrier-permeable NMDAR modulator, with EC50 values of 55 pM, 28 fM, 11 pM and 55 pM against NR2A, NR2B, NR2C and NR2D, respectively . NYX-2925 enhances synaptic plasticity, long-term potentiation, metaplasticity, structural plasticity, learning ability, memory capacity and circadian rhythm amplitude. NYX-2925 regulates the signaling pathways of Src kinase, EIF2, mTOR, CDK5 and protein kinase A (PKA). NYX-2925 increases the levels of PSD-95, GluA1, activated Src and synaptic GluN2B . NYX-2925 is used in the research of neuropathic pain, fibromyalgia, painful diabetic peripheral neuropathy, post-traumatic stress disorder, cognitive impairment, depression, age-related cognitive decline and NMDAR-mediated central nervous system diseases .
Cat. No.: HY-B0762S1
CAS No.: 362049-62-5
Synonyms: O-Acetyl-L-carnitine-d3-1 hydrochloride
Synonyms: NSI-189 phosphate
Target:
Research Areas:
Amdiglurax (NSI-189) phosphate is an orally active chemical entity with enhanced neurogenic activity. Amdiglurax phosphate up-regulates neurogenic factors such as BDNF (brain derived-neurotrophic factor) and SCF. Amdiglurax phosphate exhibits anti-depressant effect. Amdiglurax enhances synaptic plasticity and reduces cognitive dysfunction. Amdiglurax phosphate holds potential for psychiatric disorder research .
Cat. No.: HY-112828
CAS No.: 1800327-36-9
Target:
Research Areas:
LEI105 is a highly selective and reversible diacylglycerol lipase (DAGL) inhibitor that exhibits significant inhibitory activity against human DAGLα and DAGLβ (e.g., the pIC50 value against human DAGLα is 8.5, and the IC50 against human DAGLβ is 32 nM). LEI105 effectively reduces intracellular 2-arachidonoylglycerol levels and inhibits CB1 receptor-mediated short-term synaptic plasticity. LEI105 can be used to investigate the on-demand biosynthesis of 2-AG in retrograde signaling .
Cat. No.: HY-145761
CAS No.: 2097604-91-4
Target:
Research Areas:
AMPA-IN-1 is a potent inhibitor of AMPA receptor. AMPA receptors are receptors that are widely expressed in the brain, and play a central role in the regulation of fast excitatory synaptic transmission and synaptic plasticity. AMPA-IN-1 has the potential for the research of various central diseases including epilepsy (extracted from patent WO2017082288A1, compound 14) .
Cat. No.: HY-137108
CAS No.: 160385-87-5
Research Areas:
Sp-8-pCPT-cGMPS is a potent cyclic guanosine monophosphate-gated channel agonist and a lipophilic activator of protein kinase G (types I α, I β, and II) and protein kinase A type II with excellent cell membrane permeability and phosphodiesterase stability. Sp-8-pCPT-cGMPS can be used to study the role of cGMP in neural plasticity and synaptic transmission .
Cat. No.: HY-178323
CAS No.: 3048608-87-0
Target:
Research Areas:
MW073 is a highly selective and orally active 5-HT2BR antagonist (IC50 =70 nM). MW073 exerts its effects by concentration-dependently inhibiting receptor activity and β-arrestin-1 recruitment. MW073 ameliorates synaptic plasticity and behavioral deficits, including aggression, in Alzheimer’s disease (AD) mouse models. MW073 can be used for Alzheimer’s disease (AD) research [1][2].
Synonyms: Chuanxiongzine (Standard); Tetramethylpyrazine (Standard)
Cat. No.: HY-P3340
CAS No.: 189224-35-9
Target:
Research Areas:
Target:
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DU-14 is a potent steroid sulfatase inhibitor with an IC50 of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC50 = 38.7 nM). DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity .
Cat. No.: HY-P2471
Target:
Research Areas:
Cat. No.: HY-155687
Target:
Research Areas:
PDE5-IN-10 (compound 4b) is a potent PDE5 inhibitor with an IC50 of 20 nM. PDE5-IN-10 improves in vitro microsomal stability (t1/2 = 44.6 min) as well as excellent efficacy in restoring long-term potentiation. PDE5-IN-10 can be used for Alzheimer’s disease (AD) research .
Cat. No.: HY-P10630
CAS No.: 1781242-18-9
Target:
Research Areas:
Cat. No.: HY-100808R
CAS No.: 312-84-5
Synonyms: (R)-Serine (Standard)
Cat. No.: HY-121299
CAS No.: 48144-44-1
Synonyms: mCPBG
Target:
Research Areas:
m-Chlorophenylbiguanide (mCPBG) is a potent high-affinity agonist of the 5-HT3 receptor, exhibiting an inhibitory effect on long-term potentiation (LTP) in the mossy fiber-CA3 system. mCPBG attenuates the magnitude of LTP at concentrations of 0.3-1 microM, demonstrating its role in modulating synaptic plasticity. Additionally, the impact of mCPBG on LTP is reversible by the GABAA receptor antagonist bicuculline, indicating a connection between its action and GABAergic neurotransmission.
Cat. No.: HY-168966
CAS No.: 2097493-39-3
Target:
Research Areas:
JNJ-54082730 (Compound 1) is the orally active inhibitor for phosphodiesterase (PDE) that inhibits PDE2A, PDE3B, and PDE10A2 with IC50s of 0.95 nM, 6.17 μM (pIC50=5.21) and 87.1 nM (pIC50=7.06), respectively. JNJ-54082730 modulates the activity of AMPA receptor, enhance the synaptic plasticity and promotes the learning and memory function in rats models. JNJ-54082730 can cross blood-brain barrier .
Cat. No.: HY-P1057
CAS No.: 243843-43-8
Target:
Research Areas:
Synonyms: O-Acetyl-L-carnitine hydrochloride (Standard); ALCAR hydrochloride (Standard)
Category:
Cat. No.: HY-W765177
Synonyms: O-Acetyl-L-carnitine hydrochloride-13C3; ALCAR hydrochloride-13C3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
