362049-62-5
362049-62-5
Chemical Structure
Acetyl-L-carnitine-d3-1 hydrochloride
Synonym(s): O-Acetyl-L-carnitine-d3-1 hydrochloride
- CAS. Nr.: 362049-62-5
- Formula:C9H15D3ClNO4
- Molecular Weight:242.72
IUPAC Name: (R)-2-(acetoxy-d3)-3-carboxy-N,N,N-trimethylpropan-1-aminium chloride
InChIKey: JATPLOXBFFRHDN-SPMMGKNWSA-N
SMILES: C[N+](C)(C)C[C@H](OC(C([2H])([2H])[2H])=O)CC(O)=O.[Cl-]
Biological Activity: Acetyl-L-carnitine-d3-1 (O-Acetyl-L-carnitine-d3-1) hydrochloride is the deuterium labeled Acetyl-L-carnitine hydrochloride (HY-B0762). Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) hydrochloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine hydrochloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine hydrochloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine hydrochloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine hydrochloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Acetyl-L-carnitine-d3-1 hydrochloride | 99.12% | Acetyl-L-carnitine-d3-1 (O-Acetyl-L-carnitine-d3-1) hydrochloride is the deuterium labeled Acetyl-L-carnitine hydrochloride (HY-B0762). Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) hydrochloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine hydrochloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine hydrochloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine hydrochloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine hydrochloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression. | ||||||||||||||||||||
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Acetyl-L-carnitine chloride (Standard) | 99.95% | Acetyl-L-carnitine chloride (Standard) is the analytical standard of Acetyl-L-carnitine chloride. This product is intended for research and analytical applications. Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) chloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine chloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine chloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine chloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine chloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression. | ||||||||||||||||||||
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Acetyl-L-carnitine-d3 hydrochloride | 99.79% | Acetyl-L-carnitine-d3 (O-Acetyl-L-carnitine-d3) hydrochloride is the deuterium labeled Acetyl-L-carnitine hydrochloride (HY-B0762). Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) hydrochloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine hydrochloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine hydrochloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine hydrochloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine hydrochloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression. | ||||||||||||||||||||
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Acetyl-L-carnitine-d3-2 hydrochloride | Acetyl-L-carnitine-d3-2 (hydrochloride) is a deuterated Acetyl-L-carnitine. Acetyl-L-carnitine is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. | |||||||||||||||||||||
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Acetyl-L-carnitine-13C2 chloride | Acetyl-L-carnitine-13C2 (O-Acetyl-L-carnitine-13C2) chloride is the 13C-labeled Acetyl-L-carnitine (chloride) (HY-B0762). Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) chloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine chloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine chloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine chloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine chloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression. | |||||||||||||||||||||
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Acetyl-L-carnitine chloride-13C3 | Acetyl-L-carnitine chloride-13C3 (O-Acetyl-L-carnitine chloride-13C3) is the 13C-labeled Acetyl-L-carnitine chloride (HY-B0762). Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) chloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine chloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine chloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine chloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine chloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression. | |||||||||||||||||||||
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Acetyl-L-carnitine chloride | 99.95% | Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) chloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine chloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine chloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine chloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine chloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.97
HY-113218Acetyl-L-carnitine -
Similarity Score 0.97
HY-126358Acetylcarnitine -
Similarity Score 0.91
HY-126358S(R)-Acetylcarnitine-d3 -
Similarity Score 0.90
HY-113092Propionylcarnitine -
Similarity Score 0.90
HY-121705Propionyl-L-carnitine -
Similarity Score 0.89
HY-100907(±)-Acetylcarnitine chloride -
Similarity Score 0.89
HY-166290Acetyl-D-carnitine chloride -
Similarity Score 0.84
HY-B1453SL-Carnitine-d3 (hydrochloride) -
Similarity Score 0.82
HY-152015SAcetyl-L-carnitine-d6 hydrochloride -
Explore the MedChemAI to find more analogs
References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Zhu X, et al. Acetyl-L-carnitine suppresses apoptosis of thioredoxin 2-deficient DT40 cells. Arch Biochem Biophys. 2008 Oct 15;478(2):154-60. [Content Brief]
- [3]. Wang SM, et al. A review of current evidence for acetyl-l-carnitine in the treatment of depression. J Psychiatr Res. 2014 Jun;53:30-7. [Content Brief]
