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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
TRAP1
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "TRAP1" in MCE Product Catalog:
Cat. No.: HY-P703409
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TRAP1; TNF Receptor-Associated Protein 1; TNF Receptor Associated Protein 1; HSP 75; HSP75; TRAP-1; Tumor Necrosis Factor Type 1 Receptor-Associated Protein; CDNA FLJ33058 Fis, Clone TRACH1000181, Highly Similar To Heat Shock Protein 75 KDa, Mitochondrial
Species:
Rat
Source:
E. coli
Cat. No.: HY-182302
CAS No.: 1695550-43-6
Target:
Research Areas:
SMTIN-P01 is a TRAP1 inhibitor that is selective for cytosolic Hsp90 and accumulates in mitochondria. SMTIN-P01 binds to the ATP-binding site of TRAP1 as an ATP mimic, thereby inhibiting ATPase and foldase activities. SMTIN-P01 induces mitochondrial membrane depolarization and proteolytic degradation in cancer cells. SMTIN-P01 exhibits significant cytotoxicity, but shows extremely low toxicity to primary mouse hepatocytes, and does not interfere with SIRT3-related functions or the levels of cytosolic Hsp90 substrates. SMTIN-P01 has important application value in cancer-related research [1] .
Cat. No.: HY-10942R
CAS No.: 847559-80-2
Synonyms: NVP-BEP800 (Standard)
Target:
Research Areas:
VER-82576 (Standard) is the analytical standard of VER-82576 (HY-10942). This product is intended for research and analytical applications. VER-82576 (NVP-BEP800) is a potent, orally available and selective Hsp90 inhibitor, with an IC50 of 58 nM for Hsp90β; VER-82576 also slightly blocks Grp94 and Trap-1, with IC50s of 4.1 and 5.5 μM, respectively.
Cat. No.: HY-181014
Target:
Research Areas:
Glucocorticoid receptor modulator 5 (Compound D8) is a selective, orally active Glucocorticoid receptor modulator. Glucocorticoid receptor modulator 5 shows extremely high transrepression activity (TRNF-κB IC50 = 0.0009 μM, TRAP-1 IC50 = 0.0005 μM). Glucocorticoid receptor modulator 5 exerts its anti-inflammatory activity by interacting directly with the Glucocorticoid receptor signaling pathway. Glucocorticoid receptor modulator 5 significantly alleviates dermatitis and autoimmune hepatitis [1].
Cat. No.: HY-W004292S1
CAS No.: 1219803-47-0
Synonyms: Undecyl alcohol-d4
Cat. No.: HY-W004292R
CAS No.: 112-42-5
Synonyms: Undecyl alcohol (Standard)
Cat. No.: HY-10214R
CAS No.: 908112-43-6
Synonyms: PF-04928473 (Standard)
Target:
Research Areas:
SNX-2112 (Standard) is the analytical standard of SNX-2112 (HY-10214). This product is intended for research and analytical applications. SNX-2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM for Hsp90 and IC50s of 30 nM, 30 nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC50s of 10 nM, 4.275 μM and 0.862 μM, respectively [1]. SNX-2112 (PF 04928473) binds Hsp90 isoforms Hsp90α, Hsp90β and Hsp90b1/Grp94 with Kds of 4 nM, 6 nM and 484 nM, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
