847559-80-2
847559-80-2
Chemical Structure
VER-82576
Synonym(s): NVP-BEP800
- CAS No.: 847559-80-2
- Formula:C21H23Cl2N5O2S
- Molecular Weight:480.41
IUPAC Name: 2-amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
InChIKey: WJUNQSYQHHIVFX-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(N=C(N=C2S1)N)C3=CC(OCCN4CCCC4)=C(C=C3Cl)Cl)NCC
Biological Activity: VER-82576 (NVP-BEP800) is a potent, orally available and selective Hsp90 inhibitor, with an IC50 of 58 nM for Hsp90β; VER-82576 also slightly blocks Grp94 and Trap-1, with IC50s of 4.1 and 5.5 μM, respectively.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VER-82576 | 98.76% | VER-82576 (NVP-BEP800) is a potent, orally available and selective Hsp90 inhibitor, with an IC50 of 58 nM for Hsp90β; VER-82576 also slightly blocks Grp94 and Trap-1, with IC50s of 4.1 and 5.5 μM, respectively. | ||||||||||||||||||||
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VER-82576 (Standard) | ≥98% | VER-82576 (Standard) is the analytical standard of VER-82576 (HY-10942). This product is intended for research and analytical applications. VER-82576 (NVP-BEP800) is a potent, orally available and selective Hsp90 inhibitor, with an IC50 of 58 nM for Hsp90β; VER-82576 also slightly blocks Grp94 and Trap-1, with IC50s of 4.1 and 5.5 μM, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.46
HY-151515Dopamine D2 receptor agonist-2 -
Similarity Score 0.46
HY-19464Org 43553 -
Similarity Score 0.46
HY-114504RVX-297 -
Similarity Score 0.46
HY-176538Antiproliferative agent-72 -
Similarity Score 0.45
HY-171217TG-100435 -
Similarity Score 0.45
HY-113752MMV019313 -
Similarity Score 0.45
HY-122105JNJ-40255293 -
Similarity Score 0.45
HY-10185RTG 100572 hydrochloride (Standard) -
Similarity Score 0.45
HY-10184TG 100572 -
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