Antiproliferative agent-72
Antiproliferative agent-72 (Compound 10) is a Hsp90 inhibitor with a Kd of 11 nM. Antiproliferative agent-72 has antiproliferative activity with IC50s of 1.5 μM and 1.1 μM for HCT116 and NCI-N87 cells, respectively. Antiproliferative agent-72 can be used for cancers research.
For research use only. We do not sell to patients.
- CAS No.: 1052646-54-4
- Formula: C20H17Cl2N3O2S
- Molecular Weight:434.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
HSP90 11 nM (Kd) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
1.5 μM
Compound: 10
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Antiproliferative activity against human HCT116 cells
Antiproliferative activity against human HCT116 cells
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[PMID: 22192591] |
| NCI-N87 | IC50 |
1.1 μM
Compound: 10
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Antiproliferative activity against human NCI-N87 cells overexpressing Her-2
Antiproliferative activity against human NCI-N87 cells overexpressing Her-2
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[PMID: 22192591] |
Chemical Information
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CAS No. 1052646-54-4
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Molecular Weight 434.34
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Formula C20H17Cl2N3O2S
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SMILES
ClC1=CC(Cl)=C2C=C1OCCCCOC3=CC=CC(SC4=NC(N)=NC2=C4)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiproliferative agent-72 Related Classifications
HY-176538 Related Classifications
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