31 Results for "

YAP1

" in MedChemExpress (MCE) Product Catalog:
Products (31)

31 Results for "YAP1" in MCE Product Catalog:

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Cat. No.: HY-173150
CAS No.: 106928-29-4
Hapalindole Q (Compound (+)-1) is an autophagy (Autophagy) inhibitor targeting YAP1. Hapalindole Q binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM and induces its degradation via the chaperone-mediated autophagy (CMA) pathway. This process inhibits Rab7-mediated fusion of autophagosomes and lysosomes, thereby reducing overall autophagy levels without affecting lysosomal function. Hapalindole Q holds promise for research in cancer (e.g., liver cancer, breast cancer, etc.) [1].
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Cat. No.: HY-P704253
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: YAP1; YAP65; Transcriptional coactivator YAP1; Yes-associated protein 1; Protein yorkie homolog; Yes-associated protein YAP65 homolog
Species:  
Human
Source:  
E. coli
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Cat. No.: HY-173076
Target:  

HDAC YAP

Research Areas:  

Inflammation/Immunology

HDAC11-IN-1 (Compound 14-N C6OH) is a selective macrocyclic inhibitor of HDAC11 with a Ki of 40 nM. HDAC11-IN-1 exhibits good cell permeability and can inhibit the expression of YAP1 and SOX2 [1].
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Cat. No.: HY-E70293
Synonyms: GALNT12
Research Areas:  

Cancer

N-Acetylgalactosaminyltransferase 12 (GALNT12) belongs to the uridine diphosphate N-acetylgalactosamine gene family and is involved in the biological processes of many diseases, such as tumor progression. N-Acetylgalactosaminyltransferase 12 is a potential biomarker for fibrosarcoma, and its high expression level is closely related to the yes1-associated transcriptional regulator (YAP1) signaling pathway [1].
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Cat. No.: HY-P86167
Synonyms: YAP1; YAP65; Yorkie homolog; 65 kDa Yes-associated protein; YAP65

Host:  

Rabbit

Application:  

WB, ICC/IF, IP, ELISA

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-183245
CAS No.: 1332204-50-8
Target:  

YAP

Research Areas:  

Cancer

51675515 is a YAP inhibitor that inhibits YAP-dependent transcriptional activity. 51675515 reduces YAP1-GFP intensity in cells engineered to express YAP1-GFP. 51675515 can be used for the research of YAP-dependent solid tumors (including hepatocellular carcinoma, malignant mesothelioma, colorectal cancer) [1].
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Cat. No.: HY-P84342
Synonyms: YAP; YKI; YAP2; YAP65

Host:  

Mouse

Application:  

WB, IHC-P, FC, ELISA

Reactivity:  

Human, Mouse, Rat, Monkey, Rabbit

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Cat. No.: HY-P84342A
Synonyms: YAP; YKI; YAP2; YAP65

Host:  

Mouse

Application:  

WB, IHC-P, FC, ELISA

Reactivity:  

Human, Mouse, Rat, Monkey, Rabbit

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Cat. No.: HY-P80864A
Synonyms: YAP1; YAP65; Yorkie homolog; 65 kDa Yes-associated protein; YAP65

Host:  

Rabbit

Application:  

WB, IHC-P

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-189122
CAS No.: 2251130-98-8
Lpi-1 is an ATP-competitive LATS1/2 inhibitor with IC50 values of 4.4 nM and 1.3 nM, respectively. Lpi-1 blocks LATS-mediated YAP1 phosphorylation. Lpi-1 reversibly inhibits LATS1/2 in cells and in vivo, activating the YAP/TAZ signaling pathway. Lpi-1 can be used for research on acute liver injury and colitis [1].
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Cat. No.: HY-N6682R
CAS No.: 22144-77-0
Synonyms: Zygosporin A (Standard); NSC 209835 (Standard)
Cytochalasin D (Standard) is the analytical standard of Cytochalasin D (HY-N6682). This product is intended for research and analytical applications. Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .
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