62 Results for "

brain-derived

" in MedChemExpress (MCE) Product Catalog:
Products (62)

62 Results for "brain-derived" in MCE Product Catalog:

Cat. No.: HY-13999A1
CAS No.: 1270138-41-4
Purity:  99.75%
Synonyms: NSI-189 phosphate
Target:  

Trk Receptor

Research Areas:  

Neurological Disease

Amdiglurax (NSI-189) phosphate is an orally active chemical entity with enhanced neurogenic activity. Amdiglurax phosphate up-regulates neurogenic factors such as BDNF (brain derived-neurotrophic factor) and SCF. Amdiglurax phosphate exhibits anti-depressant effect. Amdiglurax enhances synaptic plasticity and reduces cognitive dysfunction. Amdiglurax phosphate holds potential for psychiatric disorder research .
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Cat. No.: HY-P3587
CAS No.: 211362-82-2
Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Brain-Derived Acidic Fibroblast Growth Factor (1-11) is a peptide fragment of brain-derived acidic fibroblast growth factor.
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Cat. No.: HY-W013372R
CAS No.: 38183-03-8
7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases .
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Cat. No.: HY-167836
CAS No.: 847-75-6
Target:  

Trk Receptor

Research Areas:  

Neurological Disease

BNN-20 is a synthetic microneurotrophin that mimics brain-derived neurotrophic factor (BDNF) and exhibits area-specific pleiotropic neuroprotective and pro-neurogenic effects. BNN-20 can be utilized in research related to Parkinson's disease .
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Cat. No.: HY-E70870
Target:  

Trk Receptor

Research Areas:  

Neurological Disease

TRKB(NTRK2) is a member of tyrosine kinase gene family. TRKB is the primary receptor for brain-derived nerve growth factor (BDNF) and neurotrophin 4/5 (NT4/5). TRKB(NTRK2) Recombinant Human Active Protein Kinase is a recombinant TRKB(NTRK2) protein that can be used to study TRKB(NTRK2)-related functions .
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Cat. No.: HY-102091
CAS No.: 169209-63-6
Synonyms: (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid
Target:  

mGluR

Research Areas:  

Neurological Disease

(2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases .
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Cat. No.: HY-175483S
CAS No.: 3087336-56-6
TrkB activator-1 is a specific, orally active and brain-penetrant tropomyosin receptor kinase B (TrkB) activator. TrkB activator-1 shows potent antidepressant effects through activation of the activates the BDNF (brainderived neurotrophic factor)-Tropomyosin-related kinase B (TrkB)-CREB (cAMP response element binding protein) signaling aixs. TrkB activator-1 increaes neuroplasticity. TrkB activator-1 can be used for the research of neurological disease, such as depression .
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Cat. No.: HY-N3297R
CAS No.: 5875-49-0
Meranzin hydrate (Standard) is the analytical standard of Meranzin hydrate (HY-N3297). This product is intended for research and analytical applications. Meranzin hydrate is an orally active antidepressant and GHSR modulator. Meranzin hydrate significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin hydrate regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin hydrate effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder .
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Cat. No.: HY-N3298R
CAS No.: 23971-42-8
Meranzin (Standard) is the analytical standard of Meranzin (HY-N3298). This product is intended for research and analytical applications. Meranzin is an orally active antidepressant and GHSR modulator. Meranzin significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder .
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Cat. No.: HY-P7116
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BDNF; Abrineurin; brain derived Neurotrophic Factor; brain-derived Neurotrophic Factor Preproprotein Isoform 2; ProBDNF; brain-derived Neurotrophic Factor Isoform 1; Neurotrophic Factor BDNF Precursor Form; ANON2; brain-derived Neurotrophic Factor; BULN2
Species:  
Mouse Human Rat
Source:  
CHO
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Cat. No.: HY-P7116G
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BDNF; Abrineurin; brain derived Neurotrophic Factor; brain-derived Neurotrophic Factor Preproprotein Isoform 2; ProBDNF; brain-derived Neurotrophic Factor Isoform 1; Neurotrophic Factor BDNF Precursor Form; ANON2; brain-derived Neurotrophic Factor; BULN2
Species:  
Human
Source:  
E. coli
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Cat. No.: HY-174337
Target:  

Drug Metabolite

Research Areas:  

Neurological Disease

PX5-9 is an orally active prodrug that can upregulate brain-derived neurotrophic factor (BDNF). PX5–9 exerts neuroprotective effects by elevating intracellular BDNF levels. PX5-9 can be used for the research of neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease) and depression, which are associated with reduced BDNF levels .
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Cat. No.: HY-W101298S
Synonyms: L-Leucyl-13C6,15N-L-isoleucine TFA
(Leu-13C6,15N)-Ile-OH (L-Leucyl-13C6,15N-L-isoleucine) TFA is the deuterium labeled Leu-Ile-OH. Leu-Ile-OH protects against neuronal death by inducing brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) synthesis .
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Cat. No.: HY-P0221B
Target:  

PACAP Receptor

Research Areas:  

Endocrinology

PACAP (1-38) free acid TFA is an endogenous neuropeptide. PACAP (1-38) free acid TFA potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid TFA also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1 .
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Cat. No.: HY-P72489
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BDNF; Abrineurin; brain derived Neurotrophic Factor; brain-derived Neurotrophic Factor Preproprotein Isoform 2; ProBDNF; brain-derived Neurotrophic Factor Isoform 1; Neurotrophic Factor BDNF Precursor Form; ANON2; brain-derived Neurotrophic Factor; BULN2
Species:  
Human
Source:  
E. coli
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Cat. No.: HY-P74383A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BDNF; Abrineurin; brain derived Neurotrophic Factor; brain-derived Neurotrophic Factor Preproprotein Isoform 2; ProBDNF; brain-derived Neurotrophic Factor Isoform 1; Neurotrophic Factor BDNF Precursor Form; ANON2; brain-derived Neurotrophic Factor; BULN2
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P72489Y
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BDNF; Abrineurin; brain derived Neurotrophic Factor; brain-derived Neurotrophic Factor Preproprotein Isoform 2; ProBDNF; brain-derived Neurotrophic Factor Isoform 1; Neurotrophic Factor BDNF Precursor Form; ANON2; brain-derived Neurotrophic Factor; BULN2
Species:  
Human
Source:  
E. coli
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Cat. No.: HY-160921
CAS No.: 769901-96-4
Synonyms: SL65.0155 free base
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

Capeserod (SL65.0155 free base) is an agonist for serotonin receptor (5-HT receptor), with a Ki of 0.6 nM for 5-HT4 receptor. Capeserod enhances expression of phopshorilated cAMP-response element binding protein (p-CREB), vascular endothelium growth factor (VEGF), brain-derived neurotrophic factor (BDNF) and B cell lymphoma-2 (Bcl-2) proteins in hippocampus, and exhibits antidepressant-like efficacy in Wistar rats models .
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Cat. No.: HY-146523
CAS No.: 2409544-80-3
Target:  

Trk Receptor

Research Areas:  

Cancer

TRK-IN-17 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-17 has the potential for the research of cancer diseases (extracted from patent WO2021148807A1, compound 3) .
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Cat. No.: HY-146524
CAS No.: 2412008-91-2
Target:  

Trk Receptor

Research Areas:  

Cancer

TRK-IN-18 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-18 has the potential for the research of cancer diseases (extracted from patent WO2021148805A1, compound 7) .
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