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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
89 Results for "
complex III
" in MedChemExpress (MCE) Product Catalog:
Products (89)
89 Results for "complex III" in MCE Product Catalog:
Synonyms: BAS 490 F
Research Areas:
Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme .
Cat. No.: HY-P1858A
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Cat. No.: HY-19882
CAS No.: 941285-15-0
BAL-30072 is a siderophore-bearing monocyclic β-lactam antibiotic with antibacterial activity. BAL-30072 inhibits penicillin-binding proteins 1a, 1b, and 3, thereby disrupting bacterial cell wall synthesis. BAL-30072 inhibits mitochondrial electron transport chain complex II and complex III, while also inhibiting glycolysis and mitochondrial fatty acid β-oxidation. BAL-30072 induces mitochondrial ROS production, cellular ATP depletion, reduces mitochondrial membrane potential, and triggers hepatocyte apoptosis via caspase-3/7 activation. BAL-30072 is a substrate of the hepatic uptake transporters OAT1 and OAT3. BAL-30072 can be used in research related to bacterial infections .
Cat. No.: HY-P1858
CAS No.: 357952-10-4
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Cat. No.: HY-115853
CAS No.: 78668-34-5
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Pyclen forms kinetically and thermodynamically stable nine-coordinate Ln (III) complexes, as well as Mn (II)-based MRI contrast agents. Pyclen-Based Mn(II) Complexes can be used for liver-specific MRI .
Cat. No.: HY-DY1017
CAS No.: 11078-21-0
Solvent and concentration: DMSO: 5 mg/mL
Cat. No.: HY-P6351
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Metyltetraprole is a QoI fungicide containing a tetrazolinone pharmacophore that binds to the Qo site of the cytochrome bc1 complex (complex III), blocks D-Panthenol (HY-B1391) oxidation, and inhibits mitochondrial electron transport, while retaining antifungal activity against QoI-resistant isolates and exhibiting broad-spectrum antifungal effects. Metyltetraprole is used in the study of wheat Septoria leaf blotch, net blotch, cucumber downy mildew, and powdery mildew .
Cat. No.: HY-107966A
CAS No.: 37270-89-6
Synonyms: Nadroparin calcium (MW 3600-5000)
Cat. No.: HY-125857B
CAS No.: 9007-43-6
Cat. No.: HY-162066
CAS No.: 2868298-43-3
DNDI-6174 is an orally active Leishmania cytochrome b (Qi site of cytochrome bc1 complex/complex III) inhibitor. DNDI-6174 binds to the Qi site of Leishmania cytochrome b, inhibits cytochrome bc1 complex activity in the parasite's electron transport chain across promastigote and axenic amastigote stages. DNDI-6174 reduces parasite burden in rodent models, inhibits growth of various Leishmania species, drug-resistant clinical isolates, and Trypanosoma cruzi, with marginal activity against Trypanosoma brucei. DNDI-6174 can be used for the research of visceral leishmaniasis, cutaneous leishmaniasis .
Cat. No.: HY-112847B
CAS No.: 1212012-37-7
Synonyms: (E/Z)-Sulfo-N-succinimidyl oleate sodium
Research Areas:
(E/Z)-Sulfosuccinimidyl oleate sodium is the racemate of (E)-Sulfosuccinimidyl oleate sodium and (Z)-Sulfosuccinimidyl oleate sodium. Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long-chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of the mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to the CD36 receptor on the surface of microglial cells. Sulfosuccinimidyl oleate sodium exhibits anti-inflammatory effects .
Cat. No.: HY-148365
Purity: 98.02%
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NecroIr1 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr1 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr1 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and Mixed Lineage Kinase (MLKL), and regulates CDK4 expression .
Cat. No.: HY-148366
Purity: 98.99%
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NecroIr2 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr2 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like pseudokinase (MLKL), and regulates CDK4 expression .
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2-Phenylimidazole (PhI) is a corrosion inhibitor for brass and can be used to prepare complexes with ruthenium (III) .
Cat. No.: HY-N10184
CAS No.: 540770-33-0
Synonyms: FKI-0550
Cat. No.: HY-114164E
CAS No.: 9002-04-4
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Rabbit Thrombin is a serine protease. Rabbit Thrombin forms a covalent complex with antithrombin III and reversibly binds endothelial cell surface high-affinity sites. Rabbit Thrombin regulates VEGF and Ang-2, potentiates VEGF mitogenic activity and protects endothelial cells from apoptosis. Rabbit Thrombin can be used for the research of hindlimb ischemia .
Cat. No.: HY-W012232
CAS No.: 3558-69-8
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2,6-Diphenylpyridine is a proton acceptor (log(P) = 5) and a tridentate [C^N^C] dianionic ligand. 2,6-Diphenylpyridine efficiently transfers protons through a direct pathway at the interface of two immiscible electrolyte solutions. 2,6-Diphenylpyridine as a tridentate ligand and can form mononuclear and binuclear complexes with gold(III). 2,6-Diphenylpyridin is applicable to research in electrochemical ion transfer kinetics and organometallic chemistry .
Cat. No.: HY-115945
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Complex III-IN-1 (Compd 4c-2) is a complex III inhibitor. Complex III-IN-1 shows antifungal activity with an EC50 of 18.53 mg/L against sclerotinia sclerotiorum .
Cat. No.: HY-115946
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Complex III-IN-2 (Compd 4d-2) is a complex III inhibitor. Complex III-IN-2 shows antifungal activity with an EC50 of 29.98 mg/L and 29.31 mg/L against sclerotinia sclerotiorum and R. solani, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
