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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
594 Results for "
Integrin
" in MedChemExpress (MCE) Product Catalog:
Products (594)
594 Results for "Integrin" in MCE Product Catalog:
PAWI-2 is a p53-Activator and Wnt Inhibitor. PAWI-2 inhibits β3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis (activation of caspase-3/7), and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin β3 KRAS-dependent human pancreatic cancer stem cells (hPCSCs). PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model .
Cat. No.: HY-171216
CAS No.: 278598-52-0
Target:
Research Areas:
GW559090 is a selective, competitive, and high-affinity α4 integrin antagonist with a Kd of 0.19 nM for α4β1. GW559090 can effectively block the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin with IC50 values of 7.72 and 8.04 nM. GW559090 also inhibits the interaction between α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (IC50 = 23 nM). GW559090 can inhibit inflammatory infiltration in the eyes, repair the corneal barrier and restore the function of goblet cells. GW559090 can be used for research of Sjögren's syndrome associated dry eye .
Cat. No.: HY-178819
Target:
Research Areas:
NM-001 is a theranostic prodrug that targets ανβ3 integrin. NM-001 consists of cRGD and GFLG peptides, a DCM fluorophore and Chlorambucil (HY-13593). NM-001 internalizes into lysosomes of tumor cells via the cRGD peptide, and generates NM-002 (HY-178820) and Chlorambucil through intracellular cleavage at the GFLG peptide by overexpressed Cathepsin B (CTSB). NM-001 exhibits green fluorescence under physiological conditions, and converts to NIR fluorescence by CTSB activation. NM-001 has significant antitumor activity with low toxicity in HeLa cell xenografts mouse models. NM-001 can be used for real-time drug release monitoring research .
Cat. No.: HY-P6442
CAS No.: 1020407-90-2
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Cat. No.: HY-P7493
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PARVA; Alpha-Parvin; Prev. MXRA2; FLJ10793; Actopaxin; CH-ILKBP; Calponin-Like Integrin-Linked Kinase-Binding Protein; Matrix-Remodelling Associated 2; Matrix-Remodeling-Associated Protein 2; Parvin Alpha; FLJ12254
Species:
Human
Source:
E. coli
Cat. No.: HY-P10667
Cat. No.: HY-P990835
Target:
Research Areas:
Cat. No.: HY-182012
Target:
Research Areas:
DT-678 is an orally active antiplatelet and antithrombotic inhibitor. DT-678 is a conjugate formed by linking the active metabolite of Clopidogrel (HY-15283) with 3-nitropyridine-2-thiol via a mixed disulfide bond. DT-678 does not rely on CYP2C19 for activation, and directly releases active substances via thiol exchange reactions in vivo, exhibiting superior efficacy over Clopidogrel. DT-678 can be used in research related to acute coronary syndrome and thrombosis .
Cat. No.: HY-D3576
Target:
Research Areas:
AF532 C5 Maleimide is a Fluorescent dye used for protein labeling. AF532 C5 Maleimide covalently binds to thiol groups via its maleimide moiety. AF532 C5 Maleimide can label VASP to support visualization studies in phase separation and focused actin polymerization experiments .
Cat. No.: HY-P10323
Synonyms: Tumstatin (74-98), human
Cat. No.: HY-N2600
CAS No.: 76472-87-2
Cat. No.: HY-P11413
CAS No.: 139446-70-1
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Cat. No.: HY-P1615
CAS No.: 1006388-38-0
Synonyms: UPARANT
Cat. No.: HY-147426
CAS No.: 2437257-11-7
Synonyms: ADS-007; ARO HIF2
Research Areas:
Zifcasiran (ADS-007; ARO HIF2) is an siRNA synthetic double-stranded RNAi trigger. Zifcasiran sodium selectively target hypoxia-inducible factor-2α (HIF2α) interrupting downstream pro-oncogenic signaling in clear cell renal cell carcinoma (ccRCC). Zifcasiran sodium engages the cell's RNAi machinery to target HIF2α (EPAS1) mRNA for degradation, thereby reducing the amount of free HIF2α mRNA available for translation .
Cat. No.: HY-P70878A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EDIL3; Developmentally-Regulated Endothelial Cell Locus 1 Protein; EGF Like And Discoidin Domains 3; EGF-Like Repeats And Discoidin I-Like Domains 3; DEL1; Integrin-Binding Protein DEL1; EGF Like Repeats And Discoidin Domains 3; Developmental Endothelial
Species:
Human
Source:
HEK293
Cat. No.: HY-P704569
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EDIL3; Developmentally-Regulated Endothelial Cell Locus 1 Protein; EGF Like And Discoidin Domains 3; EGF-Like Repeats And Discoidin I-Like Domains 3; DEL1; Integrin-Binding Protein DEL1; EGF Like Repeats And Discoidin Domains 3; Developmental Endothelial
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
