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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
113 Results for "
5-HT4
" in MedChemExpress (MCE) Product Catalog:
Products (113)
113 Results for "5-HT4" in MCE Product Catalog:
Cat. No.: HY-10564R
CAS No.: 135159-51-2
Synonyms: MCI-9042 (Standard)
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Sarpogrelate (hydrochloride) (Standard) is the analytical standard of Sarpogrelate (hydrochloride). This product is intended for research and analytical applications. Sarpogrelate hydrochloride (MCI-9042) is a selective 5-HT2R antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT1, 5-HT3, 5-HT4, α1-, α2- and β-adrenoreceptor, histamine H1, H2 and muscarinic M3 receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis .
Cat. No.: HY-103134
CAS No.: 148688-01-1
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5-HT4 antagonist 3 hydrochloride is a highly selective 5-hydroxytryptamine receptor (5-HT4) antagonist. 5-HT4 antagonist 3 (hydrochloride) blocks muscarine receptors and sodium channels. 5-HT4 antagonist 3 (hydrochloride) can be used to evaluate function of 5-HT4 receptor .
Cat. No.: HY-173131
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5-HT4R agonist-2 (Compound 4) is a selective 5-HT4R agonist with an EC50 value of 0.41 nM. 5-HT4R agonist-2 can significantly enhance whole gut and colonic transit, increase fecal output and water content, while maintaining minimal systemic absorption, and it shows promise for the research of chronic idiopathic constipation .
Cat. No.: HY-W822786
CAS No.: 144625-67-2
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GR125487 is a highly selective 5-HT4 receptor antagonist and acts as an inverse agonist at constitutively active 5-HT4 (a) receptors. GR125487 inhibits adenylyl cyclase/cAMP signaling by blocking the Gs-coupled 5-HT4 receptor. GR125487 is used in research on 5-HT4 receptor function, neuropsychiatric disorders, and gastrointestinal motility .
Cat. No.: HY-101342
CAS No.: 168986-61-6
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RS 67506 hydrochloride is a 5-HT4 receptor agonist. The pKi value of RS 67506 hydrochloride for 5-HT4 in guinea pig striatum is 8.8. RS 67506 hydrochloride can be used in neuro-related research .
Cat. No.: HY-15574R
CAS No.: 152811-62-6
Synonyms: SB-207266 (Standard)
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Piboserod (Standard) is the analytical standard of Piboserod. This product is intended for research and analytical applications. Piboserod is an orally available selective antagonist of the 5-HT4 receptor, with a Ki value of approximately 0.1 nM for human 5-HT4 receptors. Piboserod can competitively bind to the 5-HT4 receptor and block the activation of the 5-HT4 receptor. Piboserod can inhibit the enhancing effect of 5-HT on the nerve-mediated contraction response of the human bladder detrusor muscle. Piboserod is mainly used in the research of urinary system diseases (such as overactive bladder) and cardiovascular diseases (such as chronic heart failure) .
Cat. No.: HY-123747
CAS No.: 141196-99-8
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SC-53116 is a selective 5-HT4 receptor agonist with EC50 at 23 nM .
Cat. No.: HY-123747A
CAS No.: 879208-42-1
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SC-53116 hydrochloride is a selective 5-HT4 receptor agonist with EC50 at 23 nM .
Cat. No.: HY-19927A
CAS No.: 1645260-76-9
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DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist. DA-6886 induces relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels reveals that it inhibits hERG channel current with an pIC50 value of 4.3, indicating that the compound is 1000-fold more selective for the 5-HT4 receptor over hERG channels. DA-6886 can be used in the study of constipated irritable bowel syndrome .
Cat. No.: HY-101668A
CAS No.: 184159-40-8
Synonyms: RS-100302 hydrochloride
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Sulamserod hydrochloride is a 5-HT4 receptor antagonist. Sulamserod hydrochloride can be used in gastrointestinal disease related research .
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ML 10302 is a potent agonist 5-HT4 receptor with Ki of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases .
Cat. No.: HY-103143
CAS No.: 1197334-02-3
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SDZ 205-557 hydrochloride is a selective 5-HT4 receptors antagonist. SDZ 205-557 hydrochloride can be used for neurological research .
Cat. No.: HY-103143A
CAS No.: 137196-67-9
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SDZ 205-557 is a selective 5-HT4 receptors antagonist. SDZ 205-557 can be used for neurological research .
Cat. No.: HY-162591
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MR33317 is an inhibitor of acetylcholinesterase with an IC50 value of 41nM. MR33317 is also an agonist at brain 5-HT4 receptors .
Cat. No.: HY-101638
CAS No.: 129299-81-6
Synonyms: (±)-FK1052
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(±)-Fabesetron hydrochloride ((±)-FK1052) is the racemate of Fabesetron hydrochloride, which is a potent 5-HT3 and 5-HT4 receptor dual antagonist .
Cat. No.: HY-16729
CAS No.: 1221416-43-8
Synonyms: YKP10811
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Relenopride is a agonist of novel potent 5-HT4 receptor partial with weak binding to 5-HT 2B receptors (Ki = 31 nM) .
Cat. No.: HY-101638A
CAS No.: 129299-72-5
Synonyms: (±)-FK1052 free base
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(±)-Fabesetron ((±)-FK1052 free base) is the racemate of Fabesetron, which is a potent 5-HT3 and 5-HT4 receptor dual antagonist .
Cat. No.: HY-16729A
CAS No.: 1221416-42-7
Synonyms: YKP10811 hydrochloride
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Relenopride (YKP10811) hydrochloride is a specific and selective 5-HT4 receptor agonist (Ki=4.96 nM). Relenopride hydrochloride has 120-fold and 6-fold lower affinity, respectively, for 5-HT2A (Ki=600 nM) and 5-HT2B receptors (Ki=31 nM) than for 5-HT4. Relenopride hydrochloride increases gastrointestinal (GI) motility .
Cat. No.: HY-108173
CAS No.: 142228-17-9
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TKS 159 is a 5-HT4 receptor agonist. TKS 159 can promote gastrointestinal motility. TKS 159 can be used for research on gastrointestinal conditions .
Cat. No.: HY-14154
CAS No.: 886579-13-1
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THRX-194556 is a 5-HT4 receptor agonist. THRX-194556 can be used to study gastrointestinal functional disorders and Alzheimer’s disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
