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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
118 Results for "
RAC1
" in MedChemExpress (MCE) Product Catalog:
Products (118)
118 Results for "RAC1" in MCE Product Catalog:
Cat. No.: HY-106381A
Purity: ≥98.0%
Research Areas:
Aurothiomalate tetramer sodium is the tetrameric form of Aurothiomalate sodium (HY-106381). Aurothiomalate sodium acts as an inhibitor of PKCI and TrxR1. Aurothiomalate sodium disrupts the PKCI-Par6-Rac1 signaling pathway, and also inhibits TrxR1 activity, TNFα-induced NF-κB activation, and the expression of pro-inflammatory genes. Aurothiomalate sodium blocks Kras-mediated BASC expansion and lung tumor growth, inhibits anchorage-independent growth and tumorigenicity of lung cancer cells, and suppresses neutrophil chemotaxis, phagocytosis, and leukocyte extravasation. Aurothiomalate sodium can be used in research related to rheumatoid arthritis and non-small cell lung cancer [1] .
Cat. No.: HY-P1382
CAS No.: 1095179-01-3
Cat. No.: HY-P10038A
Synonyms: Myr-FEEERA-OH TFA
Cat. No.: HY-144624
CAS No.: 3033401-47-4
Target:
Research Areas:
PROTAC Axl Degrader 1 is an orally active PROTAC degrader targeting the AXL receptor tyrosine kinase, with an IC50 of 0.92 μM against human targets. PROTAC Axl Degrader 1 induces cytoplasmic vacuolization, methuosis (macropinocytosis-induced cell death), excessive macropinosome production, and Rac1 activation. PROTAC Axl Degrader 1 inhibits the proliferation and migration of cancer cells. PROTAC Axl Degrader 1 can be used in breast cancer-related research [1].
Cat. No.: HY-P1383A
Cat. No.: HY-RS16742
Target:
Research Areas:
Rac1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rac1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W127391
CAS No.: 17598-94-6
Synonyms: (RAC)-1,2-Didodecanoylglycerol
Cat. No.: HY-115507
CAS No.: 1332290-68-2
Research Areas:
NMac1 is an orally active Nm23/NDPK activator. NMac1 directly binds to Nm23-H1 and activates the NDPK activity of recombinant Nm23-H1 with an EC50 of 10.7 uM. NMac1 induces AMPK activation and inhibits mTOR and ERK, leading to mitochondrial OXPHOS dysregulation and suppressing mitochondrial ROS production, which in turn induces mitochondrial dysfunction in MDA-MB-231 cells. NMac1 inhibits Complex I activity and suppresses changes in morphology and actin cytoskeleton organization following Rac1 activation in MDA-MB-231 cells. NMac1 inhibits tumor invasion, migration and metastasis. NMac1 is useful for studying metastatic tumors, such as breast cancer. NMac1 can be isolated from the ginger cassumunar Roxb [1] .
Cat. No.: HY-P1383
CAS No.: 1315378-77-8
Target:
Research Areas:
Cat. No.: HY-RS23179
Target:
Research Areas:
Rac1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rac1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W127363
CAS No.: 13071-60-8
Cat. No.: HY-50733
CAS No.: 1009821-06-0
Target:
Research Areas:
CX-5011 free base is a potent CK2 inhibitor. CX-5011 free base also is a Rac-1 activator. CX-5011 free base induces methuosis and promotes macropinocytosis. CX-5011 free base induces apoptosis. CX-5011 free base decreases the expression of rpS6 phosphorylation [1] .
Cat. No.: HY-W010270A
CAS No.: 74916-57-7
Research Areas:
Aurothiomalate disodium acts as an inhibitor of PKCI and TrxR1. Aurothiomalate disodium disrupts the PKCI-Par6-Rac1 signaling pathway, and also inhibits TrxR1 activity, TNFα-induced NF-κB activation, and the expression of pro-inflammatory genes. Aurothiomalate disodium blocks Kras-mediated BASC expansion and lung tumor growth, inhibits anchorage-independent growth and tumorigenicity of lung cancer cells, and suppresses neutrophil chemotaxis, phagocytosis, and leukocyte extravasation. Aurothiomalate disodium can be used in research related to rheumatoid arthritis and non-small cell lung cancer [1] .
Cat. No.: HY-N8960A
CAS No.: 124898-71-1
Target:
Cat. No.: HY-W013060
CAS No.: 2190-15-0
Cat. No.: HY-W127356
CAS No.: 1246818-85-8
Cat. No.: HY-15723AR
CAS No.: 1177865-17-6
NSC 23766 (trihydrochloride) (Standard) is the analytical standard of NSC 23766 (trihydrochloride). This product is intended for research and analytical applications. NSC 23766 trihydrochloride is an inhibitor of Rac1 activation.
Cat. No.: HY-122687
CAS No.: 627042-19-7
Rac1-IN-1 is a potent Rac1 inhibitor with an IC50 of 95 nM and a Ki of 6.8 μM. Rac1-IN-1 blocks the binding of Rac1 to downstream PAK1 by targeting the nucleotide-binding site of Rac1, thereby specifically inhibiting Rac1 activation without affecting Cdc42/RhoA. Rac1-IN-1 can be used for research on pancreatic cancer [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
