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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
80 Results for "
Scd
" in MedChemExpress (MCE) Product Catalog:
Products (80)
80 Results for "Scd" in MCE Product Catalog:
Cat. No.: HY-50709R
CAS No.: 1032229-33-6
Target:
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A939572 (Standard) is the analytical standard of A939572. This product is intended for research and analytical applications. A939572 is a potent, and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively.
Cat. No.: HY-170570
CAS No.: 3053859-57-4
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PFM046 is the antagonist for liver X receptor (LXR), that inhibits the activation of LXRα and LXRβ with IC50 of 2.04 μM and 1.58 μM. PFM046 inhibits the expression of SCD1 and FASN, upregulates the expression of ABCA1, and exhibits antitumor efficacy in mouse models .
Cat. No.: HY-150125
CAS No.: 1111078-63-7
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SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition .
Cat. No.: HY-155209
CAS No.: 1673558-59-2
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SCD1 inhibitor-5 (compound 51) is a SCD1 inhibitor,with the IC50 values of 0.13 μM and 31 μM for H2122 and H1819, respectively. SCD1 inhibitor-5 can be used in cancer research .
Cat. No.: HY-RS12494
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SCD Human Pre-designed siRNA Set A contains three designed siRNAs for SCD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS12495
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Scd Rat Pre-designed siRNA Set A contains three designed siRNAs for Scd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS12497
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SCD5 Human Pre-designed siRNA Set A contains three designed siRNAs for SCD5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-114184
CAS No.: 1030612-87-3
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MK-8245 analog (compound 6) is a potent stearoyl-CoA desaturase (SCD) inhibitor with an IC50 of 7 nM for rat SCD. MK-8245 analog has antidiabetic and antidyslipidemic effects .
Cat. No.: HY-163824
CAS No.: 3036553-83-7
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WIZ degrader 7 (Example 16) is a WIZ molecular glue degrader with an IC50 value of < 0.01 μM. WIZ degrader 7 can be used to investigate sickle cell disease (SCD) and thalassemia .
Cat. No.: HY-163820
CAS No.: 2879250-22-1
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WIZ degrader 4 is a WIZ molecular glue degrader with an AC50 value of 16 nM. WIZ degrader 4 induces the expression of fetal hemoglobin (HbF) with an EC50 of 47 nM. WIZ degrader 4 can be used to investigate sickle cell disease (SCD) and thalassemia .
Cat. No.: HY-152775A
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RK-0133114 is a G9a inhibitor and a R-enantiomer of RK-701 (HY-152775). RK-0133114 inhibits G9a with an IC50 value of 3.7 μM. RK-0133114 can be used for the research of sickle cell disease (SCD) .
Cat. No.: HY-118117
CAS No.: 204386-76-5
Synonyms: S0373
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Rovatirelin is an orally active thyrotropin-releasing hormone (TRH) analog. Rovatirelin binds to the human TRH receptor with a Ki value of 702 nM. Rovatirelin can be used to study spinocerebellar degeneration (SCD) .
Cat. No.: HY-18681R
CAS No.: 1446321-46-5
Synonyms: GBT 440 (Standard)
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Voxelotor (Standard) is the analytical standard of Voxelotor. This product is intended for research and analytical applications. Voxelotor (GBT 440) is a potent inhibitor of haemoglobin S (HbS) polymerization. Voxelotor has the potential for sickle cell disease (SCD) treatment .
Cat. No.: HY-161787
CAS No.: 2648853-26-1
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G9a-IN-2 (Compound 7i) is an inhibitor for histone methyltransferases G9a with IC50 of 0.024 μM. G9a-IN-2 reduces H3K9me2 levels and induces the mRNA expression of γ-globin mRNA. G9a-IN-2 shows the potential in ameliorating sickle cell disease (SCD) .
Cat. No.: HY-111315
CAS No.: 840489-44-3
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XEN103 is a SCD1 inhibitor, with IC50s of 14 nM and 12 nM for mSCD1 and SCD1 in HepG2 cell. XEN103 can be used for research of obesity and type 2 diabetes. XEN103 also induces sebaceous gland atrophy in mice .
Cat. No.: HY-12756AR
CAS No.: 1345675-25-3
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E6446 (dihydrochloride) (Standard) is the analytical standard of E6446 (dihydrochloride). This product is intended for research and analytical applications. E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) .
Cat. No.: HY-W175543
CAS No.: 3272-27-3
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Methoxyurea (Compound 3) is a potential regulator of nitric oxide (NO) donors that acts on hemoglobins such as oxy-hemoglobin (OxyHb) and met-hemoglobin (MetHb). Methoxyurea is promising for research of sickle cell disease (SCD) .
Cat. No.: HY-18681S
CAS No.: 2170187-39-8
Synonyms: GBT 440-d6
Cat. No.: HY-139293
CAS No.: 2435610-93-6
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PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
