Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
69 Results for "
Go
" in MedChemExpress (MCE) Product Catalog:
Products (69)
69 Results for "Go" in MCE Product Catalog:
Cat. No.: HY-173431
CAS No.: 3082344-46-2
Research Areas:
Dopamine D4 receptor ligand 3 (Compound 16) is a dopamine D4 receptor (D4R) antagonist (pKi: 8.86). Dopamine D4 receptor ligand 3 has pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors in HEK-293T cells, respectively. Dopamine D4 receptor ligand 3 inhibits the viability of three human glioma cell lines, U87 MG, T98G, and U251 MG. Dopamine D4 receptor ligand 3 induces ROS production and mitochondrial dysfunction in glioma cells .
Cat. No.: HY-13867AR
CAS No.: 176504-36-2
Synonyms: GF109203X hydrochloride (Standard); Go 6850 hydrochloride (Standard)
Target:
Research Areas:
Bisindolylmaleimide I (hydrochloride) (Standard) is the analytical standard of Bisindolylmaleimide I (hydrochloride). This product is intended for research and analytical applications. Bisindolylmaleimide I (GF109203X) hydrochloride is a cell-permeable and reversible PKC inhibitor (IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I hydrochloride is also a GSK-3 inhibitor .
Cat. No.: HY-RS17054
Target:
Research Areas:
Fgf5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fgf5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-180992
Target:
Research Areas:
Dual GO/LDHA-IN-1 is an orally available dual inhibitor targeting glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), with Ki values of 390 nM and 40 nM, respectively. Dual GO/LDHA-IN-1 reduces hepatic LDHA levels, urinary oxalate excretion, and renal calcium-oxalate crystal deposition. Dual GO/LDHA-IN-1 is applicable for research on primary hyperoxaluria type 1 .
Cat. No.: HY-101684
CAS No.: 47439-36-1
Synonyms: CIBA 2330Go
Target:
Research Areas:
Nitroxazepine is a tricyclic antidepressant (TCA) for the research of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor.
Cat. No.: HY-101684A
CAS No.: 16398-39-3
Synonyms: CIBA 2330Go hydrochloride
Target:
Research Areas:
Nitroxazepine hydrochloride is a tricyclic antidepressant (TCA) for the study of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor.
Target:
Research Areas:
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization .
Target:
Cat. No.: HY-19117
CAS No.: 113241-47-7
Target:
Research Areas:
BRL-32872 is a potent human ether-a-go-go-related gene (hERG) potassium channel blocker (IC50=241 nM in isolated cardiomyocytes; 19.8 nM in HEK293 cells). BRL-32872 is promising for research of cardiac arrhythmias (e.g., atrial/ventricular rhythms) .
Cat. No.: HY-10800
CAS No.: 876922-98-4
Target:
Research Areas:
GSK-588045 is a potent 5-HT(1A/B/D) receptor antagonist. GSK-588045 shows high degree of selectivity over human ether-a-go-go related gene (hERG) potassium channels. GSK-588045 can be used for the research of neurological disease, such as depression and anxiety .
Cat. No.: HY-103268
CAS No.: 1227163-56-5
Target:
Research Areas:
(Rac)-AZD3839 is an orally active beta-amyloid precursor protein cleaving enzyme (BACE1) inhibitor that is blood-brain barrier-permeable. (Rac)-AZD3839 has an affinity for the human ether-a-go-go related gene (hERG) ion channel. (Rac)-AZD3839 can be used in the research of Alzheimer's disease .
Cat. No.: HY-15194R
CAS No.: 52328-98-0
Synonyms: ASC-J9 (Standard); Go-Y025 (Standard)
Target:
Cat. No.: HY-B1482AS
CAS No.: 2514954-64-2
Cat. No.: HY-183265
Research Areas:
GO847 is an orally active casein kinase 2 (CK2) inhibitor with an IC50 of 40.2 nM. GO847 increases intracellular ATP levels, impairs Mitochondrial metabolic flexibility, and promotes excessive mitochondrial ROS production. GO847 alters the period length of cellular circadian rhythms. GO847 inhibits the growth of acute myeloid leukemia cells. GO847 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-175505
CAS No.: 2894793-37-2
Target:
Research Areas:
Dopamine D3 receptor antagonist-3 is a D3 dopamine receptor (D3R)-selective positive allosteric modulator (PAM)-antagonist that can cross the blood-brain barrier. Dopamine D3 receptor antagonist-3 exhibits antagonist activity in the D3R-mediated β-arrestin recruitment assay with an IC50 and a Kd of 2.5 μM and 0.49 μM. amine D3 receptor antagonist-3 is also an antagonist in the D3R-mediated Go-BRET assay with an IC50 of 0.34 μM. Dopamine D3 receptor antagonist-3 can be used for the study of neuropsychiatric disorders, including substance use disorder .
Cat. No.: HY-13689G
CAS No.: 133053-19-7
Cat. No.: HY-137059
CAS No.: 1217503-60-0
Research Areas:
GO-Y078 is a curcumin (HY-N0005) analog. GO-Y078 activates p38/JNK1/2. GO-Y078 activates the MAPK pathway, Caspase 3/8/9, PARP, AP-1, DR5, and TP53, while inhibiting cIAP-1, XIAP, and NF-κB. GO-Y078 induces sub-G1/G2/M phase arrest and Apoptosis. GO-Y078 impairs angiogenesis. GO-Y078 can be used in research related to osteosarcoma, cervical cancer, oral squamous cell carcinoma, and peritoneal metastasis of gastric cancer .
Cat. No.: HY-183402
CAS No.: 917813-60-6
Synonyms: Go-Y026
Target:
Research Areas:
FLLL12 (GO-Y026) is a curcumin analog anticancer agent. FLLL12 inhibits the phosphorylation of AKT, Bcl-2, Bid, EGFR, mTOR, FOXO1a, FOXO3a, STAT3, HER2/neu, as well as pancreatic AKT/STAT3; upregulates the expression of Bim and DR5; and activates PTPs. FLLL12 regulates downstream pathways, induces mitochondria-mediated and DR5-dependent extrinsic apoptosis, inhibits cancer cell viability, proliferation, anchorage-independent growth and migration, and exerts a synergistic effect with Doxorubicin (HY-15142A). FLLL12 can be used in research related to head and neck squamous cell carcinoma, breast cancer, prostate cancer, pancreatic cancer, lung cancer, colon cancer and colorectal cancer .
Cat. No.: HY-P701834
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KCNH2; HERG1; Prev. LQT2; Potassium Voltage-Gated Channel Subfamily H Eag-Related Member 2; HERG; Ether-A-Go-Go-Related Potassium Channel Protein; Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2; Voltage-Gated Channel Subfamily H Member 2; Voltage-Gated Inwardly Rectifying Potassium Channel KCNH2; Human Ether-A-Go-Go-Related Gene; Ether-A-Go-Go-Related Gene Potassium Channel 1; Uncharacterized Protein KCNH2; Voltage-Gated Potassium Channel Subunit Kv11.1; Human Ether-A-Go-Go-Related; Kv11.1; Potassium Channel HERG1; Erg1; Potassium Channel HERG; Ether-A-Go-Go-Related Protein 1; KCNH2 Protein; Long QT Syndrome Type 2; HERG-1; Eag-Related Protein 1; SQT1; Eag Homolog; ERG1; ERG-1; ERG; H-ERG; Potassium Voltage-Gated Channel Subfamily H Member 2; Potassium Channel, Voltage Gated Eag Related Subfamily H, Member 2
Species:
Human
Source:
HEK293
Cat. No.: HY-P703937
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: KCNH2; HERG1; Prev. LQT2; Potassium Voltage-Gated Channel Subfamily H Eag-Related Member 2; HERG; Ether-A-Go-Go-Related Potassium Channel Protein; Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2; Voltage-Gated Channel Subfamily H Member 2; Voltage-Gated Inwardly Rectifying Potassium Channel KCNH2; Human Ether-A-Go-Go-Related Gene; Ether-A-Go-Go-Related Gene Potassium Channel 1; Uncharacterized Protein KCNH2; Voltage-Gated Potassium Channel Subunit Kv11.1; Human Ether-A-Go-Go-Related; Kv11.1; Potassium Channel HERG1; Erg1; Potassium Channel HERG; Ether-A-Go-Go-Related Protein 1; KCNH2 Protein; Long QT Syndrome Type 2; HERG-1; Eag-Related Protein 1; SQT1; Eag Homolog; ERG1; ERG-1; ERG; H-ERG; Potassium Voltage-Gated Channel Subfamily H Member 2; Potassium Channel, Voltage Gated Eag Related Subfamily H, Member 2
Species:
Human
Source:
HEK293
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
