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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
70 Results for "
KOR
" in MedChemExpress (MCE) Product Catalog:
Products (70)
70 Results for "KOR" in MCE Product Catalog:
Cat. No.: HY-15691A
CAS No.: 1322001-35-3
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PF-4455242 hydrochloride is an orally bioavailable, blood-brain barrier-permeable κ-opioid receptor (KOR) inhibitor. PF-4455242 hydrochloride blocks in vivo effects induced by KOR and MOR agonists, and elicits KOR-independent outward currents in ventral tegmental area neurons. PF-4455242 hydrochloride promotes energy expenditure and activates the hypothalamic mTOR pathway. PF-4455242 hydrochloride attenuates stress-induced behavioral effects and produces antidepressant-like effects. PF-4455242 hydrochloride can be used in studies related to pain, depression, addictive disorders, and obesity induced by estrogen withdrawal .
Cat. No.: HY-122169
CAS No.: 36292-69-0
Synonyms: Ketocyclazocine
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Ketazocine (Ketocyclazocine) is a selective κ-opioid receptor (KOR) agonist. Ketazocine is promising for research of analgesics and sedatives .
Cat. No.: HY-178720
CAS No.: 2168573-03-1
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SHR0687 is a selective tetrapeptide kappa opioid receptor (KOR) agonist with an EC50 of 0.53 pM. SHR0687 displays high potency and selectivity over MOR and DOR, with negligible blood-brain barrier penetration. SHR0687 activates KOR specifically, leading to potential modulation of neurological pathways without significant central nervous system effects. SHR0687 can be used for the research of pain .
Cat. No.: HY-105235A
CAS No.: 124439-07-2
Synonyms: CI-977 hydrochloride
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Enadoline (CI-977) hydrochloride is a highly selective, brain-penetrating, and nonpeptide kappa-opioid receptor (KOR) agonist (Ki=1.25 nM). Antinociceptive effects .
Cat. No.: HY-163917
CAS No.: 2439152-14-2
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SalA-VS-08 is a full agonist of kappa-opioid receptor (KOR) with selectivity and G-protein bias. SalA-VS-08 can be used in the research of analgesia .
Cat. No.: HY-163916
CAS No.: 2445895-33-8
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SalA-VS-07 is a G protein-biased partial agonist for the Kappa-opioid receptor (KOR). SalA-VS-07 can be used for research of pain and other disorders .
Cat. No.: HY-107744R
CAS No.: 55096-26-9
Target:
Opioid Receptor Apoptosis Reactive Oxygen Species (ROS) NO Synthase Toll-like Receptor (TLR) p38 MAPK NF-κB Reference Standards
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Nalmefene (Standard) is the analytical standard of Nalmefene. This product is intended for research and analytical applications. Nalmefene is a long acting opioid (MOR and DOR antagonist), and a partial KOR agonist. Nalmefene is used for opioid overdose and alcohol dependence .
Cat. No.: HY-130696
CAS No.: 67198-17-8
Synonyms: (+)-Trans-(1R,2R)-U-50488
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(+)-U-50488 ((+)-Trans-(1R,2R)-U-50488) is a less active κ opioid receptor (KOR) agonist than the enantiomer of (-)-Trans-(1S,2S)-U-50488 (HY-15997) .
Cat. No.: HY-15997A
CAS No.: 114528-81-3
Synonyms: (+)-Trans-(1R,2R)-U-50488 hydrochloride
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(+)-U-50488 (hydrochloride) (+)-Trans-(1R,2R)-U-50488 hydrochloride) is a less active κ opioid receptor (KOR) agonist than the enantiomer of (-)-Trans-(1S,2S)-U-50488 (HY-15997) .
Cat. No.: HY-P4679
CAS No.: 103613-84-9
Synonyms: E2078
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Cat. No.: HY-P1333A
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Cat. No.: HY-161812
CAS No.: 3050669-97-8
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MOR agonist-4 (2d) is a G protein signaling-biased Kappa opioid receptor (KOR) agonist with an EC50 value of 11 nM. MOR agonist-4 contains an electron withdrawing CF3 group and a bias factor of 38 based on triazole. MOR agonist-4 is used in the research of pruritis and analgesia .
Cat. No.: HY-181515
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KOR agonist 8 (Compound 8a) is a κ-opioid receptor (KOR) agonist and an analgesic agent, with a Ki value of 5.3 nM for human KOR, and EC50 values of 43.1 nM and 9236 nM for human KOR. It exhibits subtype selectivity for MOR/KOR and DOR/KOR. KOR agonist 8 is applicable for pain-related research .
Cat. No.: HY-P1625
CAS No.: 103614-28-4
Synonyms: Dynorphin A ethylamide (1-9)
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Cat. No.: HY-183773
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KOR agonist-9 is a selective kappa opioid receptor (KOR) agonist with an EC50 of 1.41 nM. KOR agonist-9 exhibits >125-fold selectivity over μ/δ-opioid receptors. KOR agonist-9 antinociceptive and antipruritic effects in mice. KOR agonist-9 can be used for the research of pain, pruritus .
Cat. No.: HY-187342
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KOR modulator-1 is a blood-brain barrier-permeable kappa opioid receptor (KOR) modulator. KOR modulator-1 induces antinociceptive effects without significant sedation or impairment of neuromuscular coordination. KOR modulator-1 can be used for the research of chronic pain .
Cat. No.: HY-P83387A
Synonyms: KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
Cat. No.: HY-145128A
CAS No.: 126766-42-5
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GR103545 is a κ opioid receptor (KOR) selective PET radiotracer and functional agonist with blood-brain barrier permeability and comparable peripheral and central antinociceptive efficacy, with an IC50 of 0.02 nM for KOR agonistic activity. GR103545 selectively binds to KORs in the brain. GR103545 induces antinociceptive effects. GR103545 can be used in research related to neurological disorders such as depression and Alzheimer's disease .
Cat. No.: HY-RS21006
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Oprk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Oprk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
