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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
62 Results for "
selectins
" in MedChemExpress (MCE) Product Catalog:
Products (62)
62 Results for "selectins" in MCE Product Catalog:
Cat. No.: HY-N1480S3
CAS No.: 478518-51-3
Synonyms: 6-Desoxygalactose-13C-3; L-(-)-Fucose-13C-3; L-Galactomethylose-13C-3
Cat. No.: HY-160109A
CAS No.: 1334320-77-2
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Ac5GalNTGc epimer is an analogue of hexosamine and the racemate of Ac5GalNTGc (HY-160109). Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research .
Cat. No.: HY-106428
CAS No.: 169543-49-1
Synonyms: ITF1697
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Cat. No.: HY-172541
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LN6023 (hydrochloride) (Compound 27) is a CXCR7 agonist. LN6023 (hydrochloride) induces the recruitment of β-arrestin in HEK293T cells expressing human CXCR7 (EC50 = 3.5 µM). LN6023 (hydrochloride) reduces the surface level of P-selectin in isolated and washed human platelets. LN6023 (hydrochloride) can be used to study platelet-mediated thrombosis .
Cat. No.: HY-P10770
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Cat. No.: HY-158458
Synonyms: A2[3]G1F1(a1-3) glycan
Cat. No.: HY-P11798
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Cat. No.: HY-P991794
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Cat. No.: HY-158495
Synonyms: A2 N-linked oligosaccharide, 2-AA labelled
Cat. No.: HY-158522
Synonyms: A2[3]G1 & A2[6]G1 N-linked oligosaccharide, 2-AB labelled
Cat. No.: HY-187596
CAS No.: 133669-72-4
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Sjc 13 is an inhibitor of E-selectin and VCAM-1, with IC50 values of 150 μg/mL and 115 μg/mL, respectively. Sjc 13 prevents neutrophil migration and adhesion by selectively inhibiting the expression and mRNA synthesis of E-selectin and VCAM-1 in LPS-stimulated endothelial cells, thereby protecting against LPS-induced lethal shock. Sjc 13 is applicable to the study of septic shock .
Cat. No.: HY-P992212
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Cat. No.: HY-187620
CAS No.: 148550-96-3
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PD 144795 is an orally active inhibitor of E-selectin (E-selectin), ICAM-1, and VCAM-1, with IC50 values of 6.6 μM, 4.0-10 μM, and 4.0 μM for the human targets, respectively. PD 144795 has favorable pharmacokinetic properties, including good absorption and no endothelial cytotoxicity. PD 144795 inhibits TNF-α-induced adhesion of neutrophils and monocytes to endothelial cells, reduces neutrophil infiltration, exudate accumulation, and footpad swelling, and delays disease progression in rodent models. PD 144795 can be used for inflammation-related research .
Cat. No.: HY-172491A
DSPE-PEG3400-ESBP is a PEG compound which composed of DSPE and a E-selectin-binding peptide (ESBP). As a tumor-targeting peptide, ESBP can specifically recognize and bind to receptors or markers on the surface of tumor cells .
Cat. No.: HY-182533
CAS No.: 3035425-93-2
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LN5972 is a selective ACKR3 agonist with an EC50 of 3.40 μM, showing higher selectivity for ACKR3 over CXCR4. LN5972 induces β-arrestin recruitment to ACKR3/CXCR7. LN5972 reduces the surface expression of P-selectin. LN5972 is applicable to studies related to platelet-mediated thrombosis .
Cat. No.: HY-189067
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IP/EP4 receptor agonist-1 is a PGI2 analog and also an IP/EP4 receptor agonist. IP/EP4 receptor agonist-1 inhibits PAR-mediated integrin αIIbβ3 activation, P-selectin exposure, platelet aggregation and thrombus formation. IP/EP4 receptor agonist-1 can be used in research related to pulmonary hypertension .
Cat. No.: HY-183516
CAS No.: 19220-35-0
Synonyms: OPG
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Osteoprotegerin (OPG) belongs to the tumor necrosis factor receptor (TNFR) superfamily . Osteoprotegerin blocks the RANKL-RANK interaction as well as the binding of TRAIL to its receptor. Osteoprotegerin activates NF-κB to induce the expression of ICAM-1, VCAM-1 and E-selectin, and activates the phosphorylation of ERK1/2. Osteoprotegerin regulates osteoclast activity, inhibits osteoclast maturation and formation, bone lysis and bone resorption, and increases bone mass. Osteoprotegerin regulates vascular endothelial cell function. Osteoprotegerin can be used in the research of cardio-cerebrovascular and bone-related diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
