IP/EP4 receptor agonist-1
IP/EP4 receptor agonist-1 is a PGI2 analog and also an IP/EP4 receptor agonist. IP/EP4 receptor agonist-1 inhibits PAR-mediated integrin αIIbβ3 activation, P-selectin exposure, platelet aggregation and thrombus formation. IP/EP4 receptor agonist-1 can be used in research related to pulmonary hypertension.
For research use only. We do not sell to patients.
- Formula: C22H28F2O5
- Molecular Weight:410.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
EP4 |
IP Receptor |
αIIbβ3 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Platelet | IC50 |
0.009 nM
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Inhibition of PAR-mediated integrin αIIbβ3 activation in human platelets assessed via FACS analysis after 5 min pre-incubation with test compound followed by 10 min stimulation with 5 μM SFLLRN.
Inhibition of PAR-mediated integrin αIIbβ3 activation in human platelets assessed via FACS analysis after 5 min pre-incubation with test compound followed by 10 min stimulation with 5 μM SFLLRN.
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42503823 |
| Platelet | IC50 |
0.011 nM
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Inhibition of PAR-mediated P-selectin exposure in human platelets assessed via FACS analysis after 5 min pre-incubation with test compound followed by 10 min stimulation with 5 μM SFLLRN.
Inhibition of PAR-mediated P-selectin exposure in human platelets assessed via FACS analysis after 5 min pre-incubation with test compound followed by 10 min stimulation with 5 μM SFLLRN.
|
42503823 |
| Platelet | IC50 |
0.008 nM
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Inhibition of PAR-mediated P-selectin exposure in human platelets assessed via FACS analysis after 5 min pre-incubation with pure Z-9 isomer followed by 10 min stimulation with 5 μM SFLLRN.
Inhibition of PAR-mediated P-selectin exposure in human platelets assessed via FACS analysis after 5 min pre-incubation with pure Z-9 isomer followed by 10 min stimulation with 5 μM SFLLRN.
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42503823 |
In Vitro
IP/EP4 receptor agonist-1 (Z-9) potently inhibits PAR-mediated integrin αIIbβ3 activation and P-selectin exposure in human platelets, with IC50 values of 0.009 nM and 0.008 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 410.45
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Formula C22H28F2O5
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SMILES
O=C(CCC/C=C(C1(F)F)\O[C@@H]2[C@H]1[C@H]([C@@H](C2)O)C#C[C@H]([C@H](CC#CCC)C)O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IP/EP4 receptor agonist-1 Related Classifications
HY-189067 Related Classifications
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