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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6698 Results for "
blocking
" in MedChemExpress (MCE) Product Catalog:
Products (6698)
6698 Results for "blocking" in MCE Product Catalog:
Cat. No.: HY-P992454
Cat. No.: HY-P992511
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Cat. No.: HY-P99488
CAS No.: 2574591-89-0
Synonyms: JSP-191; AMG-191
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Cat. No.: HY-P99618
CAS No.: 2377419-89-9
Synonyms: IBI-315; BH2950
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Cat. No.: HY-P99965
CAS No.: 1917321-26-6
Synonyms: SKY59; RO7112689; RG-6107
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Cat. No.: HY-P9S0062
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Rosnilimab (Mouse IgG2a) is a mouse-derived IgG2a antibody, Rosnilimab. Rosnilimab is a PD-1 agonistic monoclonal antibody. Rosnilimab (Mouse IgG2a) optimizes the inhibitory PD-1 signaling pathway without blocking PD-L1 binding; it also activates moderately activated PD-1 + T cells and eliminates PD-1 high cells, Tfh/Tph cells and Teff cells. Rosnilimab (Mouse IgG2a) reduces the secretion and gene expression of IFN-γ, CXCL13, IL-6 and TNF, decreases macrophage infiltration, and downregulates the gene expression of inflammatory myeloid cells. Rosnilimab (Mouse IgG2a) can be used in studies related to ulcerative colitis .
Cat. No.: HY-W008581
CAS No.: 1035-77-4
Synonyms: 3-O-Methyl estradiol; 17β-Estradiol 3-methyl ether; 3-Methoxyestradiol
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Estradiol 3-methyl ether (EDME) is a highly selective TRPML1 ion channel antagonist and microtubule (microtubule) depolymerizing agent, with IC50 values of 0.22 μM and 3.8 μM against TRPML1 and TRPML2, respectively; it shows no activity against TRPML3. Estradiol 3-methyl ether induces the disruption of cytoplasmic microtubule networks in mammalian cells, with an EC50 of 9 μM. Independent of estrogen receptors, Estradiol 3-methyl ether blocks autophagy (autophagy), TFEB nuclear translocation, and inhibits the migration and invasion of triple-negative breast cancer cells by suppressing TRPML1. Estradiol 3-methyl ether is applicable for relevant research on triple-negative breast cancer .
Cat. No.: HY-W047709
CAS No.: 140-07-8
Synonyms: THEED; THEEN
N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine (THEED; THEEN) is a tetrapodal pentadentate chelating ligand that functions as a chelator to form stable complexes with metal ions. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine serves as a versatile building block for organic synthesis, a reagent for metal extraction, and an auxiliary for catalytic reactions. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine-derived metal complexes exhibit antibacterial, antifungal, and anticancer activities. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine and its metal complexes can be used for research related to breast cancer, leukemia, various bacterial and fungal infections .
Cat. No.: HY-W153159
CAS No.: 13062-76-5
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Cat. No.: HY-W153897
CAS No.: 370-98-9
Category:
Alkaloids Human Gut Microbiota Metabolites Leguminosae Other Alkaloids Acacia auriculiformis A.Cunn. ex Benth Plants Endogenous metabolite
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Cat. No.: HY-W460666
CAS No.: 251647-50-4
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5'-O-DMT-N2-Ibu-2'-OMe-G is a crucial intermediate for the synthesis of antisense oligonucleotides. 5'-O-DMT-N2-Ibu-2'-OMe-G is involved in constructing antisense oligonucleotides with specific sequences, which can bind complementarily to the targeted mRNA. 5'-O-DMT-N2-Ibu-2'-OMe-G blocks the translation process of mRNA, thereby inhibiting the expression of specific proteins and playing a role in regulating gene expression. 5'-O-DMT-N2-Ibu-2'-OMe-G is promising for research of genetic diseases and tumors .
Cat. No.: HY-W490804
CAS No.: 2971-36-0
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HPTE is the active in vivo metabolite of Methoxychlor (HY-B1873), and acts as an inhibitor of 3β‑HSD and 17β‑HSD3. HPTE binds to the substrate-binding pocket of 3β‑HSD in a non-competitive manner, but competitively occupies the coenzyme NAD +-binding site, thereby inhibiting the conversion of pregnenolone to progesterone. HPTE binds to the androstenedione-binding pocket (the substrate pocket) of 17β‑HSD3 in a non-competitive manner, and competitively occupies the coenzyme NADPH-binding site, thus blocking the conversion of androstenedione to testosterone. HPTE interferes with androgen biosynthesis in Leydig cells by inhibiting the activities of these two key steroidogenic enzymes. HPTE can be used in studies related to androgen biosynthesis .
Cat. No.: HY-W583212
CAS No.: 14354-67-7
Synonyms: ZnMP
Cat. No.: HY-W654334
Cat. No.: HY-W747310
CAS No.: 79262-46-7
Synonyms: Cipazoxapine; CGP 19486A
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Savoxepine (Cipazoxapine; CGP 19486A) is a dopamine antagonist with antipsychotic activity. Savoxepine preferentially blocks hippocampal dopamine D2 receptors and also inhibits dopamine-stimulated adenylate cyclase activity. Savoxepine shows strong interactions with α-adrenergic receptors, serotonin 5-HT2 receptors and histamine H1 receptors, and moderate interactions with α2-adrenergic receptors, histamine H2 receptors, serotonin 5-HT1 receptors and cholinergic muscarinic receptors. Savoxepine inhibits dopamine agonist-induced stereotyped behaviors in animals, induces catalepsy in animals, and antagonizes Apomorphine (HY-12723)-induced climbing behavior in mice. Savoxepine can be used in schizophrenia-related research .
Cat. No.: HY-W778179
CAS No.: 1329840-53-0
Synonyms: LRCL 3794-13C,d3
Cat. No.: HY-W778408
CAS No.: 1346606-38-9
Synonyms: ICI 47699-13C6; (Z)-Tamoxifen-13C6; trans-Tamoxifen-13C6
Cat. No.: HY-W778649
CAS No.: 1795136-21-8
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Cat. No.: HY-Y1219C
CAS No.: 112926-00-8
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
