14354-67-7
Chemical Structure
Zn(II) Mesoporphyrin IX
Synonym(s): ZnMP
- CAS No.: 14354-67-7
- Formula:C34H36N4O4Zn
- Molecular Weight:630.05
InChIKey: YQJXHPBQEBGWBG-RGGAHWMASA-L
SMILES: O=C(CCC1=C(C)C2=CC3=C(C)C(CC)=C4C=C5C(C)=C(CC)C6=[N]5[Zn+2]([N-]34)([N-]78)[N]2=C1C=C8C(CCC(O)=O)=C(C)C7=C6)O
Biological Activity:
Zn (II) Mesoporphyrin IX (ZnMP) is a heme oxygenase inhibitor with photochemical substrate activity. Zn (II) Mesoporphyrin IX specifically inhibits the activity of bone marrow heme oxygenase. In vitro, Zn (II) Mesoporphyrin IX inhibits the growth of erythroid and myeloid progenitor cells in rabbit bone marrow, and blocks the rhG-CSF-induced mobilization of these progenitor cells into the peripheral blood, exhibiting toxicity to hematopoietic growth and progenitor cell production in rabbits. Zn (II) Mesoporphyrin IX undergoes irreversible photochemical decomposition conforming to first-order kinetic characteristics when irradiated with UV-B in 95% ethanol solution. Zn (II) Mesoporphyrin IX can be used in hematopoietic regulation research, but its photolability and toxic effects on the hematopoietic system require attention[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zn(II) Mesoporphyrin IX | 95.0% | Zn (II) Mesoporphyrin IX (ZnMP) is a heme oxygenase inhibitor with photochemical substrate activity. Zn (II) Mesoporphyrin IX specifically inhibits the activity of bone marrow heme oxygenase. In vitro, Zn (II) Mesoporphyrin IX inhibits the growth of erythroid and myeloid progenitor cells in rabbit bone marrow, and blocks the rhG-CSF-induced mobilization of these progenitor cells into the peripheral blood, exhibiting toxicity to hematopoietic growth and progenitor cell production in rabbits. Zn (II) Mesoporphyrin IX undergoes irreversible photochemical decomposition conforming to first-order kinetic characteristics when irradiated with UV-B in 95% ethanol solution. Zn (II) Mesoporphyrin IX can be used in hematopoietic regulation research, but its photolability and toxic effects on the hematopoietic system require attention. |
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- [1]. Lutton JD, et al. Comparative pharmacology of zinc mesoporphyrin and tin mesoporphyrin: toxic actions of zinc mesoporphyrin on hematopoiesis and progenitor cell mobilization. Pharmacology. 1999;58(1):44-50. [Content Brief]
- [2]. Zvezdanović J B, et al. Zinc (II) and copper (II) complexes with pheophytin and mesoporphyrin and their stability to UV-B irradiation: Vis spectroscopy studies[J]. Journal of the Serbian Chemical Society, 2012, 77(2): 187-199.
Keywords
