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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
105 Results for "
Molt3/XIAP
" in MedChemExpress (MCE) Product Catalog:
Products (105)
105 Results for "Molt3/XIAP" in MCE Product Catalog:
Cat. No.: HY-153200
CAS No.: 2761969-85-9
MDM2/XIAP-IN-2 is a dual inhibitor of murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). MDM2/XIAP-IN-2 degrades MDM2, and inhibits XIAP mRNA translation to inhibits cancer cells. Particularly, MDM2/XIAP-IN-2 inhibits acute lymphoblastic leukemia cell line EU-1 with an IC50 value of 0.3 μM .
Cat. No.: HY-175177
Xiap-casp7 PPI-IN-1 is a reversible XIAP: CASP7 inhibitor with specifically disrupting the interaction between XIAP and CASP7. XIAP-CASP7 PPI-IN-1 selectively induce MCF-7 and other caspase-3 down-regulation (CASP3/DR) triple-negative breast cancer cell apoptosis. XIAP-CASP7 PPI-IN-1 overcomes chemoresistance via down-regulating β-catenin and its associated ABC transporters in Paclitaxel (HY-B0015)-resistant MCF-7 cells. XIAP-CASP7 PPI-IN-1 can be used for the study of breast cancer .
Cat. No.: HY-175450
Research Areas:
XIAP ligand-Linker Conjugate 2 is an E3 ligase ligand-linker conjugate that incorporates the XIAP BIR2 ligand XB2M54 (HY-175348) and linker. XIAP ligand-Linker Conjugate 2 can be used for synthesis of PROTAC GNE-1567 (HY-175448) .
Cat. No.: HY-RS15873
Target:
Research Areas:
XIAP Human Pre-designed siRNA Set A contains three designed siRNAs for XIAP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS15875
Target:
Research Areas:
XIAP Rat Pre-designed siRNA Set A contains three designed siRNAs for XIAP gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-175444
Research Areas:
XIAP ligand-Linker Conjugate 1 is an E3 ligase ligand-linker conjugate that incorporates the XIAP BIR2 ligand XB2M54 (HY-175348) and linker. XIAP ligand-Linker Conjugate 1 can be used for synthesis of PROTAC ERα Degrader-1 (HY-112098) .
Cat. No.: HY-160030
CAS No.: 1434125-52-6
XIAP BIR2/BIR2-3 inhibitor-3 is a dual inhibitor of BIR2 and BIR2-3 with IC50s less than 1 nM. XIAP BIR2/BIR2-3 inhibitor-3 can used in study cancers .
Cat. No.: HY-138059A
Purity: 98.57%
SM-433 hydrochlorid, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 hydrochlorid exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM (patent WO2008128171A2) .
Cat. No.: HY-N15378
CAS No.: 132541-62-9
Target:
Cat. No.: HY-167704
CAS No.: 99777-90-9
NF023 is a compound that inhibits X-BIR1/TAB1 assembly activity. NF023 can affect cell survival signaling pathways by interfering with XIAP-mediated NF-κB activation. NF023 also shows potential as a selective P2X1 adenylate receptor antagonist. This compound has the potential to synergize with existing pro-apoptotic drugs and play an important role in cancer suppression .
Cat. No.: HY-168893
K882 (Compound 4e) is a Src inhibitor, with KD of 0.315 μM. K882 induces Apoptosis. K882 inhibits XIAP and Survivin. K882 inhibits the activation of PI3K/Akt/mTOR, Jak1/Stat3, Ras/MAPK signaling pathways. K882 shows anti-tumor activity against non-small cell lung cancer .
Cat. No.: HY-13721R
CAS No.: 81267-65-4
Synonyms: Idronoxil (Standard); Dehydroequol (Standard); Haginin E (Standard)
Research Areas:
Phenoxodiol (Standard) is the analytical standard of Phenoxodiol. This product is intended for research and analytical applications. Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner .
Cat. No.: HY-150596
CAS No.: 2460738-32-1
Target:
Research Areas:
CT1-3 is a potent anticancer agent. CT1-3 induces mitochondria-mediated apoptosis by regulating JNK/Bcl-2/Bax/XIAP pathway. CT1-3 suppresses the epithelial mesenchymal transition (EMT) potential of human cancer cells (HCCs) via regulating the E-cadherin/Snail axis, thus inhibits tumorigenesis. CT1-3 has a strong antitumor effect in mice model and exhibits no significant hepatic and renal toxicity .
Cat. No.: HY-168739
CAS No.: 2413582-45-1
Target:
Topoisomerase Reactive Oxygen Species (ROS) Apoptosis Survivin Bcl-2 Family IAP DNA/RNA Synthesis
Research Areas:
Topoisomerase I inhibitor 17 (Compound 7h) is a Topoisomerase I (Top1) inhibitor. Topoisomerase I inhibitor 17 reduces DDX5 and reverses the locking of Top1 activity by DDX5. Topoisomerase I inhibitor 17 induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. Topoisomerase I inhibitor 17 induces Apoptosis (reduces antiapoptotic proteins XIAP, Bcl-2, Survivin and up-regulates pro-apoptotic proteins Bax, γH2AX). Topoisomerase I inhibitor 17 also blocks the progression of the G2/M checkpoint and induces cell cycle arrest. Topoisomerase I inhibitor 17 significantly inhibits colony formation and cell migration in colorectal cancer cells. Topoisomerase I inhibitor 17 effectively reduces tumors in human PDX tumor mice .
Cat. No.: HY-N0732R
CAS No.: 37905-08-1
Cat. No.: HY-175925
Research Areas:
XIAP ligand 6 is a XIAP ligand and can be used for the synthesis of PROTACs, such as CST626 (HY-149924) .
Cat. No.: HY-P73485
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: XIAP; X-Linked Inhibitor Of Apoptosis; BIRC4; API3; E3 Ubiquitin-Protein Ligase XIAP; X-Linked Inhibitor Of Apoptosis, E3 Ubiquitin Protein Ligase; Baculoviral IAP Repeat-Containing Protein 4; RING-Type E3 Ubiquitin Transferase XIAP; Inhibitor Of Apoptosi
Species:
Human
Source:
E. coli
Cat. No.: HY-P73537
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: XIAP; X-Linked Inhibitor Of Apoptosis; BIRC4; API3; E3 Ubiquitin-Protein Ligase XIAP; X-Linked Inhibitor Of Apoptosis, E3 Ubiquitin Protein Ligase; Baculoviral IAP Repeat-Containing Protein 4; RING-Type E3 Ubiquitin Transferase XIAP; Inhibitor Of Apoptosi
Species:
Human
Source:
E. coli
Cat. No.: HY-P704995
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: XIAP; X-Linked Inhibitor Of Apoptosis; BIRC4; API3; E3 Ubiquitin-Protein Ligase XIAP; X-Linked Inhibitor Of Apoptosis, E3 Ubiquitin Protein Ligase; Baculoviral IAP Repeat-Containing Protein 4; RING-Type E3 Ubiquitin Transferase XIAP; Inhibitor Of Apoptosi
Species:
Human
Source:
E. coli
Cat. No.: HY-P706127
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: XIAP; X-Linked Inhibitor Of Apoptosis; BIRC4; API3; E3 Ubiquitin-Protein Ligase XIAP; X-Linked Inhibitor Of Apoptosis, E3 Ubiquitin Protein Ligase; Baculoviral IAP Repeat-Containing Protein 4; RING-Type E3 Ubiquitin Transferase XIAP; Inhibitor Of Apoptosi
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
