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Cat. No.: HY-153200

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MDM2/XIAP-IN-2

MDM2/XIAP-IN-2 is a dual inhibitor of murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). MDM2/XIAP-IN-2 degrades MDM2, and inhibits XIAP mRNA translation to inhibits cancer cells. Particularly, MDM2/XIAP-IN-2 inhibits acute lymphoblastic leukemia cell line EU-1 with an IC₅₀ value of 0.3 μM.

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CAS No.: 2761969-85-9
화학식: C₂₉H₃₂N₂O₄S
분자량:504.64

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

MDM2/XIAP-IN-2 Chemical Structure

CAS No.: 2761969-85-9

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

murine double minute 2 (MDM2); X-linked inhibitor of apoptosis protein (XIAP)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	2.2 μM Compound: 14; JW-2-107	Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 72 hrs by WST assay Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 72 hrs by WST assay	[PMID: 37130471]
CWR22R	IC₅₀	5.3 μM Compound: 14; JW-2-107	Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 37130471]
MDA-MB-231	IC₅₀	2.2 μM Compound: 14; JW-2-107	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 37130471]

Chemical Information

CAS No. 2761969-85-9
분자량 504.64
화학식 C₂₉H₃₂N₂O₄S
SMILES

O=S(C1=CC2=C(NC(C3=CC=C(C(C(C)C)=O)C=C3)C4C2OCC4)C=C1)(NC5=CC=C(C)C(C)=C5)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu Z, et al. Discovery of N-(3, 4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2, 3, 3a, 4, 5, 9b-hexahydrofuro [3, 2-c] quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor[J]. Journal of medicinal chemistry, 2021, 64(4): 1930-1950.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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