MDM2/XIAP-IN-2
MDM2/XIAP-IN-2 is a dual inhibitor of murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). MDM2/XIAP-IN-2 degrades MDM2, and inhibits XIAP mRNA translation to inhibits cancer cells. Particularly, MDM2/XIAP-IN-2 inhibits acute lymphoblastic leukemia cell line EU-1 with an IC50 value of 0.3 μM.
For research use only. We do not sell to patients.
- CAS No.: 2761969-85-9
- Formula: C29H32N2O4S
- Molecular Weight:504.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
murine double minute 2 (MDM2); X-linked inhibitor of apoptosis protein (XIAP)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
2.2 μM
Compound: 14; JW-2-107
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Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 72 hrs by WST assay
Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 72 hrs by WST assay
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[PMID: 37130471] |
| CWR22R | IC50 |
5.3 μM
Compound: 14; JW-2-107
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Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
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[PMID: 37130471] |
| MDA-MB-231 | IC50 |
2.2 μM
Compound: 14; JW-2-107
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
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[PMID: 37130471] |
Chemical Information
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CAS No. 2761969-85-9
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Molecular Weight 504.64
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Formula C29H32N2O4S
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SMILES
O=S(C1=CC2=C(NC(C3=CC=C(C(C(C)C)=O)C=C3)C4C2OCC4)C=C1)(NC5=CC=C(C)C(C)=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MDM2/XIAP-IN-2 Related Classifications
HY-153200 Related Classifications
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