2. Apoptosis
  3. MDM-2/p53
  4. MDM2/XIAP-IN-2

MDM2/XIAP-IN-2 is a dual inhibitor of murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). MDM2/XIAP-IN-2 degrades MDM2, and inhibits XIAP mRNA translation to inhibits cancer cells. Particularly, MDM2/XIAP-IN-2 inhibits acute lymphoblastic leukemia cell line EU-1 with an IC50 value of 0.3 μM.

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MDM2/XIAP-IN-2

MDM2/XIAP-IN-2 Chemical Structure

CAS No. : 2761969-85-9

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MDM2/XIAP-IN-2 Related Antibodies

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Description

MDM2/XIAP-IN-2 is a dual inhibitor of murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). MDM2/XIAP-IN-2 degrades MDM2, and inhibits XIAP mRNA translation to inhibits cancer cells. Particularly, MDM2/XIAP-IN-2 inhibits acute lymphoblastic leukemia cell line EU-1 with an IC50 value of 0.3 μM[1].

IC50 & Target

murine double minute 2 (MDM2); X-linked inhibitor of apoptosis protein (XIAP)[1]
Cellular Effect
Cell Line Type Value Description References
A-375 IC50
2.2 μM
Compound: 14; JW-2-107
Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 72 hrs by WST assay
Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 72 hrs by WST assay
[PMID: 37130471]
CWR22R IC50
5.3 μM
Compound: 14; JW-2-107
Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 37130471]
MDA-MB-231 IC50
2.2 μM
Compound: 14; JW-2-107
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 37130471]
Molecular Weight

504.64

Formula

C29H32N2O4S
CAS No.
SMILES

O=S(C1=CC2=C(NC(C3=CC=C(C(C(C)C)=O)C=C3)C4C2OCC4)C=C1)(NC5=CC=C(C)C(C)=C5)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MDM2/XIAP-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2/XIAP-IN-22761969-85-9MDM-2/p53lymphoblastic leukemia cell line EU-1Inhibitorinhibitorinhibit

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