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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
73 Results for "
nuclear localization
" in MedChemExpress (MCE) Product Catalog:
Products (73)
73 Results for "nuclear localization" in MCE Product Catalog:
Cat. No.: HY-182566
CAS No.: 288246-59-3
ITI-367 is a HIV-1 inhibitor that targets the nuclear localization signal 1 (NLS-1) of HIV-1 matrix protein and the interaction between HIV-1 pre-integration complex (PIC) and importin-β. ITI-367 inhibits HIV-1 replication at the pre-integration stage, reduces the formation of 2-LTR circles, and sequesters viral DNA in the cytoplasm. ITI-367 can be used for the research of HIV infection .
Cat. No.: HY-101859R
CAS No.: 1404091-23-1
Synonyms: Nuc-H2O2 Probe (Standard)
Cat. No.: HY-P11662
CAS No.: 521076-75-5
Target:
Research Areas:
Cat. No.: HY-174791
The Cre-T2A-GFP mRNA is a capped and polyadenylated messenger RNA encoding a Cre recombinase with a nuclear localization sequence (NLS) and a green fluorescent protein (GFP). The incorporation of N1-Methylpseudo-UTP can reduce the immunogenicity of the resulting mRNA.
Cat. No.: HY-DY1113
CAS No.: 1404104-40-0
Target:
Research Areas:
Endoplasmic reticulum dye 1 (solution) is a rhenium (I)-based luminescent, membrane-permeable cell imaging reagent with low cytotoxicity, photobleaching resistance, and suitability for multicolor imaging. Endoplasmic reticulum dye 1 (solution) localizes to the nuclear membrane, endoplasmic reticulum, and nucleoplasmic reticulum in live cells. Endoplasmic reticulum dye 1 (solution) enables detection of exocytosis events, dynamic changes in nuclear membrane-derived phagosomes, and vesicle trafficking processes .
Solvent and concentration: DMSO: 10 mM
Solvent and concentration: DMSO: 10 mM
Cat. No.: HY-188110
Cas9-T2A-GFP mRNA-LNP is a lipid nanoparticle (LNP) encapsulating Cas9-T2A-GFP mRNA. Cas9-T2A-GFP mRNA encodes a Cas9 nuclease gene with two nuclear localization signals (NLS) and green fluorescent protein (GFP), which can be used for genome engineering experiments.
Cat. No.: HY-187486A
Synonyms: DOPE-PEG2000-Mal-Cys-MPG
Target:
Research Areas:
DOPE-PEG2000-MPG (DOPE-PEG2000-Mal-Cys-MPG) is an amphiphilic lipid-PEG-peptide conjugate consisting of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the MPG peptide, a cell-penetrating peptide derived from the HIV-1 gp41 fusion peptide and the nuclear localization sequence (NLS) of SV40 large T antigen. DOPE-PEG2000-MPG is used for intracellular delivery of siRNA, DNA, and other macromolecules.
Cat. No.: HY-D3195
CAS No.: 2028316-19-8
Cat. No.: HY-119590
CAS No.: 31501-55-0
Synonyms: Lonchocarpine
Cat. No.: HY-188108
Cas9-T2A-GFP mRNA (N1-Methylpseudo-UTP)-LNP is a lipid nanoparticle (LNP) encapsulating Cas9-T2A-GFP mRNA (N1-Methylpseudo-UTP). Cas9-T2A-GFP mRNA (N1-Methylpseudo-UTP) encodes a Cas9 nuclease gene with two nuclear localization signals (NLS) and green fluorescent protein (GFP), which can be used for genome engineering experiments. N1-Methylpseudo-UTP can reduce the immunogenicity of the generated mRNA.
Cat. No.: HY-188109
Target:
Research Areas:
Cas9-T2A-GFP mRNA (N1-Methylpseudo-UTP)-LNP is a lipid nanoparticle (LNP) encapsulating Cas9-T2A-GFP mRNA (N1-Methylpseudo-UTP). Cas9-T2A-GFP mRNA (N1-Methylpseudo-UTP) encodes a Cas9 nuclease gene with two nuclear localization signals (NLS) and green fluorescent protein (GFP), which can be used for genome engineering experiments. N1-Methylpseudo-UTP can reduce the immunogenicity of the generated mRNA.
Cat. No.: HY-N19791
CAS No.: 13410-15-6
Category:
Monophenols Coumarins Phenols Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Phenylpropanoids Plants Umbelliferae
Target:
Cat. No.: HY-171881
CAS No.: 864686-48-6
Research Areas:
BI-5521 is an orally active GSK-3 inhibitor with an IC50 of 1.1 nM against GSK-3β. BI-5521 targets the two GSK-3 isoforms with similar potency and exhibits potent inhibitory activity against DYRK1A. By modulating GSK-3 activity, BI-5521 inhibits tumor proliferation and cancer cell growth, exerts cytotoxic effects, and reduces cancer cell viability. It shows consistent chemosensitivity across all subtypes of rhabdomyosarcoma, produces synergistic growth inhibitory effects when combined with SOS1 inhibitors, reduces oral glucose levels, regulates the myofibroblast differentiation pathway, decreases the nuclear localization of YAP/SMAD2/3, and lowers the positive rate of α-SMA in fibroblasts without affecting the apoptosis of CD4 + T cells. BI-5521 can be used in the research of non-small cell lung cancer, pleomorphic rhabdomyosarcoma, type 2 diabetes, pancreatic ductal adenocarcinoma, Alzheimer's disease, bipolar disorder, and metabolic dysfunction-associated steatotic liver disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
