Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
912 Results for "
ring
" in MedChemExpress (MCE) Product Catalog:
Products (912)
912 Results for "ring" in MCE Product Catalog:
Cat. No.: HY-P702993
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TRAF2; TNF Receptor-Associated Factor 2; TNF Receptor Associated Factor 2; Tumor Necrosis Factor Type 2 Receptor Associated Protein 3; TRAP3; Tumor Necrosis Factor Type 2 Receptor-Associated Protein 3; RNF117; TNF Receptor-Associated Factor; ring-Type E3
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703021
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRPF19; ring-Type E3 Ubiquitin Transferase PRP19; Prev. PRP19; Senescence Evasion Factor; NMP200; PRP19/PSO4 Homolog; SNEV; Psoralen 4; Pre-MRNA-Processing Factor 19; PRP19/PSO4 Pre-MRNA Processing Factor 19 Homolog (S. Cerevisiae); UBOX4; PRP19/PSO4 Pre-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P811871
Synonyms: TRIML2; Tripartite Motif Family Like 2; SPRYD6; Probable E3 Ubiquitin-Protein Ligase TRIML2; ring-Type E3 Ubiquitin Transferase TRIML2; Tripartite Motif Family-Like Protein 2; SPRY Domain-Containing Protein 6; FLJ25801; SPRY Domain Containing 6; EC 2.3.2.27
Cat. No.: HY-P811871A
Synonyms: TRIML2; Tripartite Motif Family Like 2; SPRYD6; Probable E3 Ubiquitin-Protein Ligase TRIML2; ring-Type E3 Ubiquitin Transferase TRIML2; Tripartite Motif Family-Like Protein 2; SPRY Domain-Containing Protein 6; FLJ25801; SPRY Domain Containing 6; EC 2.3.2.27
Cat. No.: HY-151738
CAS No.: 1935981-35-3
Target:
Research Areas:
Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-182354
CAS No.: 861877-12-5
VEGFR2-IN-84 is an orally active, multi-targeted tyrosine kinase inhibitor based on a naphthalene ring scaffold. VEGFR2-IN-84 inhibits VEGFR2 with sub-nanomolar affinity and broadly targets kinases including Kit, FGFR, PDGFR, and Ret. By competitively binding to the ATP-binding pocket, VEGFR2-IN-84 blocks the phosphorylation of VEGFR2 and its downstream AKT/ERK signaling pathway, thereby significantly inhibiting endothelial cell proliferation, migration, and tumor angiogenesis. VEGFR2-IN-84 exhibits broad-spectrum antiproliferative activity against various solid tumors such as liver cancer, lung cancer, and renal cancer, shows weak toxicity to normal cells, and has superior potency to Lenvatinib (HY-10981). VEGFR2-IN-84 possesses favorable pharmacokinetic properties and high safety (LD50>2000 mg/kg), and can be used in related studies of various malignant tumors .
Cat. No.: HY-D3120
CAS No.: 2246946-53-0
Target:
Research Areas:
LysoAIE2 is a Fluorescent probe for lysosomal viscosity detection and live-cell imaging. Its detection mechanism relies on the aggregation-induced emission effect: it exhibits only weak fluorescence in non-viscous media; in viscous environments, restricted intramolecular motion inhibits non-radiative energy dissipation pathways, thereby significantly enhancing fluorescence intensity. It achieves specific targeting of lysosomes through the proton acceptor property of its indole ring structure, while its hydroxyl group endows it with excellent water solubility. This probe is basically unaffected by microenvironmental polarity and pH within the range of pH 4.0 to pH 8.0, which avoids interference from these factors in viscosity measurement. LysoAIE2 has an emission wavelength of 570 nm. It can be used to monitor lysosomal viscosity changes during processes such as Dexamethasone (HY-14648)-induced lysosomal migration and starvation-induced mitophagy in live cells; at concentrations up to 40 μM, cell viability remains above 80%, demonstrating excellent biocompatibility .
Cat. No.: HY-D3416
Synonyms: TAMRA-2,4-dinitroaniline
Target:
Research Areas:
TMR-DN (TAMRA-2,4-dinitroaniline) is a fluorescent probe for RNA imaging that consists of a covalently coupled fluorophore (5-carboxy tetramethylrhodamine (TMR)) and quencher (dinitroaniline (DN)). The Kd value of TMR-DN with SRB-2 is 35 nM, and its Kd value with RhoBAST is approximately 30 nM. TMR-DN has a contact quenching function and forms a non-fluorescent intramolecular ground-state dimer in the free state; the excitation/emission wavelengths of the free probe are Ex/Em = 557/579 nm, those of the complex formed by binding to SRB-2 are Ex/Em = 561/587 nm, and those of the probe bound to the DNB aptamer are Ex/Em = 555/582 nm. TMR-DN reduces non-specific binding to genomic nucleic acids via negatively charged carboxyl-functionalized aromatic rings. Fluorescence dequenching occurs when TMR-DN specifically binds to SRB-2, RhoBAST or the DNB aptamer, among which the binding of RhoBAST requires Mg 2+ for proper folding .
Cat. No.: HY-N0259R
CAS No.: 110623-73-9
Synonyms: Epmedin B (Standard)
Cat. No.: HY-P790103
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TRAF3; CD40 Receptor-Associated Factor 1; TNF Receptor Associated Factor 3; TNF Receptor-Associated Factor; CRAF1; CD40 Associated Protein 1; CAP-1; CD40 Binding Protein; LAP1; CD40-Binding Protein; RNF118; IMD132B; CD40bp; IMD132A; ring-Type E3 Ubiquitin
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-176498
CAS No.: 1246952-34-0
Synonyms: BMX
Research Areas:
NBM-T-BMX-OS01 (BMX) is a derivative of Osthole (HY-N0054). NBM-T-BMX-OS01 attenuates the phosphorylation levels of ERK and Akt in an AMPK-dependent manner. NBM-T-BMX-OS01 induces oxidative stress through the production of ROS. NBM-T-BMX-OS01 enhances Cisplatin-induced cell proliferation inhibition, colony formation inhibition, apoptosis (apoptosis) and cell cycle arrest. NBM-T-BMX-OS01 inhibits VEGF-induced phosphorylation of VEGFR2 and FAK. NBM-T-BMX-OS01 inhibits VEGF-induced endothelial cell proliferation, migration and tube formation, as well as microvessel sprouting in rat aortic rings and angiogenesis induced by colorectal cancer cells. NBM-T-BMX-OS01 inhibits the growth of subcutaneous colorectal cancer xenografts in nude mice. NBM-T-BMX-OS01 can be used in studies related to lung cancer, colorectal cancer and angiogenesis .
Cat. No.: HY-W027592R
CAS No.: 61-82-5
Cat. No.: HY-L907
12,373 compounds
The most prominent mechanism of action of kinase inhibitors is their competition with ATP by binding to the hinge region of the kinase protein. Once the kinase is blocked by an inhibitor, it loses the ability to transfer phosphate groups from ATP to other molecules, resulting in the loss of kinase activity.
The hinge-binding region of kinase inhibitors mimics the interaction pattern between the ATP nucleobase and the kinase. MCE extracted thousands of kinase inhibitors from the ChEMBL database and isolated their molecular fragments. In certain cases, the amino and amide groups on the molecular fragments are crucial for binding in the hinge region. Therefore, we enhanced the diversity of the collected results by adding these two groups to unoccupied positions on the ring system. Subsequently, the fragments were assessed for their hinge region binding ability via docking at distinct kinases, we also applied pharmacophore constraints to ensure interactions with key amino acids in the kinase hinge region, ultimately obtaining kinase-related molecular fragments.
MCE provides over 12,373 kinase fragment molecules that meet the above requirements and are available off the shelf, serving as an effective tool for screening and developing drugs targeting kinases.
Cat. No.: HY-P702072
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: DTX3L; Rhysin-2; Deltex E3 Ubiquitin Ligase 3L; Rhysin2; BBAP; Deltex 3 Like, E3 Ubiquitin Ligase; RNF143; Deltex 3-Like (Drosophila); ring-Type E3 Ubiquitin Transferase DTX3L; Protein Deltex-3-Like; B-Lymphoma- And BAL-Associated Protein; Deltex 3-Like; E3 Ubiquitin-Protein Ligase DTX3L; Rhysin 2
Species:
Human
Source:
E. coli
Cat. No.: HY-P811862
Synonyms: UBR7; Ubiquitin Protein Ligase E3 Component N-Recognin 7; C14orf130; Ubiquitin Protein Ligase E3 Component N-Recognin 7 (Putative); Putative E3 Ubiquitin-Protein Ligase UBR7; ring-Type E3 Ubiquitin Transferase UBR7; N-Recognin-7; Chromosome 14 Open Reading Frame 130; EC 2.3.2.27; LICAS
Cat. No.: HY-182361
CAS No.: 3097515-05-1
NUAK1-IN-3 is a potent and selective NUAK1 inhibitor with an IC50 of 0.49 nM. NUAK1-IN-3 also inhibits NUAK2 and JAK3 with IC50 values of 265 and 225 nM. NUAK1-IN-3 engages Glu139 of NUAK1, forms a salt bridge between its bicyclic ring nitrogen and Asp142, and uses a fluorine atom to enhance hydrophobic binding interactions. NUAK1-IN-3 attenuates MYPT1 phosphorylation, suppresses the NUAK1-MYPT1 signaling axis, and inhibits proliferation, migration, and invasion of triple-negative breast cancer cells. NUAK1-IN-3 reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) marker alterations, downregulates Snail and N-cadherin, and upregulates E-cadherin in tumor tissues. NUAK1-IN-3 suppresses tumor growth in triple-negative breast cancer xenograft models. NUAK1-IN-3 can be used for the research of triple-negative breast cancer .
Cat. No.: HY-D3128
CAS No.: 2348351-60-8
Target:
Research Areas:
Mito-RhFe is a Fluorescent probe for mitochondrial labile Fe³⁺ monitoring via imaging and flow cytometry. This probe is a rhodamine-based construct with a spirolactam fluorescence signaling group and an N2-hydroxyethyldiethylenetriamine chelator; its delocalized positive charge enables mitochondria-targeting ability in live cells, and it exhibits fine cell membrane permeability. In its native state, it exists in the non-fluorescent spirolactam form, but upon binding to Fe³⁺, it undergoes a ring-opening conversion to the fluorescent rhodamine form, triggering a turn-on fluorescent response; this process is reversible, as the addition of the metal chelator TPEN removes Fe³⁺ and converts the probe back to its non-fluorescent spirolactam form, and re-addition of Fe³⁺ restores fluorescence. The probe shows high selectivity for Fe³⁺ over most other metal cations present in living systems, with a ~90-fold fluorescence enhancement upon binding to 20 equiv of Fe³⁺. Mito-RhFe has excitation/emission wavelengths of Ex/Em = 540/578 nm, with an ~8 nm bathochromic shift in emission upon Fe³⁺ binding, and it can also be excited at 543 nm for confocal imaging with emission detected at 570-620 nm[1].
Cat. No.: HY-P811862A
Synonyms: UBR7; Ubiquitin Protein Ligase E3 Component N-Recognin 7; C14orf130; Ubiquitin Protein Ligase E3 Component N-Recognin 7 (Putative); Putative E3 Ubiquitin-Protein Ligase UBR7; ring-Type E3 Ubiquitin Transferase UBR7; N-Recognin-7; Chromosome 14 Open Reading Frame 130; EC 2.3.2.27; LICAS
Research Areas:
U7D-1 is a USP7 PROTAC degrader that induces selective proteasomal degradation of USP7. U7D-1 destabilizes and downregulates the expression of variant PRC1 complex subunits PCGF1, RING1A and PCGF6, and also slightly reduces the protein level of KDM2B. U7D-1 decreases cell viability, arrests neuroblastoma cells at the G0/G1 cell cycle phase, and downregulates the expression of target genes of PAX3::FOXO1 in FP-RMS cells. U7D-1 increases the level of cleaved PARP in FP-RMS cells, induces cell apoptosis, and upregulates the expression of muscle differentiation markers MYH1 and MYF5. U7D-1 inhibits the growth and proliferation of p53 wild-type and mutant cancer cells, and regulates the apoptosis pathway and E2F pathway. U7D-1 is applicable to studies on neuroblastoma, fusion-positive rhabdomyosarcoma, p53-mutant cancers and cancer-related research .
Cat. No.: HY-P812032
Synonyms: TUBGCP3; Tubulin Gamma Complex Component 3; GCP3; Spc98p; SPBC98; Tubulin Gamma Complex Associated Protein 3; Spindle Pole Body Protein Spc98 Homolog; Gamma-ring Complex Protein 104 KDa; Gamma-Tubulin Complex Component 3; Tubulin, Gamma Complex Associated Protein 3; Spindle Pole Body Protein; HGrip104; Grip104; HSpc98; Spc98; GCP-3; HGCP3; H104p; 104p; ALP6
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
