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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
267 Results for "
Fes
" in MedChemExpress (MCE) Product Catalog:
Products (267)
267 Results for "Fes" in MCE Product Catalog:
Cat. No.: HY-E71931
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5-Methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase (EC 2.1.1.258) is a transferase that can convert methyl-Co(III)-[corrinoid Fe-S protein] and (6S)-5,6,7,8-tetrahydrofolate into Co(I)-[corrinoid Fe-S protein], (6S)-5-methyl-5,6,7,8-tetrahydrofolate and H +.
Cat. No.: HY-E71602
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2-Oxoacid oxidoreductase (ferredoxin) (EC 1.2.7.11) contains thiamine diphosphate and [4Fe-4S] clusters.
Cat. No.: HY-E71610
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2-Oxoglutarate synthase (EC 1.2.7.3) contains thiamine diphosphate and two [4Fe-4S] clusters.
Cat. No.: HY-W075620
CAS No.: 1341134-09-5
NH2-MIL-88B (Fe) is a metal-organic framework (MOF) with coordinatively unsaturated iron sites and carbon monoxide-releasing activity. NH2-MIL-88B (Fe) binds with carbon monoxide to form Fe 2+-CO and Fe 3+-CO adducts, and releases the bound carbon monoxide under physiological conditions, serving as a carrier and delivery vehicle for gaseous transmitters .
Cat. No.: HY-N17362
CAS No.: 24099-25-0
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Cat. No.: HY-16168AS1
Synonyms: FE 200486-d7 TFA
Cat. No.: HY-D3123
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Ac-MtFluNox is a mitochondria-targeted Fluorescent probe that can be used for the selective detection of labile Fe (II). Ac-MtFluNox can enter living cells, where intracellular esterases cleave its acetyl protecting group to generate activated MtFluNox. Ac-MtFluNox functions through an Fe (II)-mediated deoxygenation mechanism of its amine N-oxide group, which eliminates the fluorescence quenching effect and oxidizes Fe (II) to Fe (III) to deplete the catalytically active Fe (II) pool. A FITC filter set (excitation 465-500 nm, emission 516-556 nm) is used for live-cell imaging. Ac-MtFluNox can be applied to studies related to myocardial ferroptosis .
Cat. No.: HY-D3127
CAS No.: 455251-97-5
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DCA-Mln is a Fluorescent probe for ferric iron (Fe³⁺) detection. The probe works via an internal charge transfer (ICT) process from its diethylamino group to its dicyano group, which produces bright pink fluorescence in its unbound state; when Fe³⁺ is present, two molecules of DCA-Mln chelate with one Fe³⁺ ion, with one cyano group of each DCA-Mln participating in the complexation, and this binding triggers a photoinduced electron transfer (PET) process that provides a nonradiative deactivation pathway, resulting in fluorescence quenching; additionally, the probe exhibits a visible color change from purple to peach pink upon Fe³⁺ binding, enabling dual-channel detection. The probe has an excitation wavelength of 570 nm and an emission wavelength of 670 nm, and it shows a rapid response, with fluorescence stabilizing within 15 seconds of Fe³⁺ addition. DCA-Mln is cell-membrane-permeable, nontoxic at the imaging concentration of 10 μM, and can be used for Fe³⁺ detection in actual water samples, Fe³⁺ imaging in living cells, and as an anti-counterfeiting ink[1].
Cat. No.: HY-W075622
CAS No.: 1291088-77-1
Synonyms: ((2-Amino-4-carboxylatobenzoyl)oxy)(hydroxy)iron(III)
NH2-MIL-53(Fe) (((2-Amino-4-carboxylatobenzoyl)oxy)(hydroxy)iron(III)) is a metal-organic framework (MOF).
Cat. No.: HY-D3116
CAS No.: 2711762-70-6
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RhoNox-4 is a ferroptosis inhibitor and a fluorescence activation indicator specific to Fe 2+. RhoNox-4 selectively reacts with labile Fe 2+ and oxidizes it to Fe 3+, depleting labile Fe 2+ involved in lipid peroxidation and inhibiting ferroptosis induced by ferroptosis inducers. RhoNox-4 is cell-permeable, accumulates in the endoplasmic reticulum and/or Golgi apparatus, can be used for live-cell imaging and high-throughput screening of subcellular iron status regulators, and is applicable to iron biology research .
Cat. No.: HY-D3125
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NtHzBtd is a fluorescent probe for detecting Fe 3+. NtHzBtd is applicable to the selective fluorescent detection of Fe 3+ ions and live cell imaging studies. NtHzBtd can selectively coordinate with Fe 3+ to form a 1:1 complex, triggering chelation enhanced quenching (CHEQ) and intramolecular charge transfer (ICT) processes, which result in fluorescence turn-off, thereby enabling sensitive detection of Fe 3+ and live cell fluorescence imaging. After binding to Fe 3+, NtHzBtd reduces fluorescence intensity, exhibits a rapid response property, with a limit of detection of 0.036 μM and a response time of approximately 55 s. The detection wavelengths are Ex/Em = 334/401 nm (solution system) .
Cat. No.: HY-E71575
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2-Iminoacetate synthase (EC 4.1.99.19) binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule.
Cat. No.: HY-16168AS2
Synonyms: FE 200486-d7 TFA-1
Cat. No.: HY-184636
PLL coated Fe2O3 nanoparticles (Polylysine-modified ferric oxide magnetic nanoparticles) consist of a polylysine (PLL)-modified ferric oxide (Fe2O3) core and pure water.
Cat. No.: HY-D3122
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Mem-RhoNox is a fluorescent probe used to detect labile Fe (II) on the plasma membrane surface and inside endosomes during iron uptake in live cells. Mem-RhoNox can anchor to the extracellular surface of the plasma membrane; upon contact with Fe (II), its N-oxide group undergoes a deoxygenation reaction, converting weakly fluorescent Mem-RhoNox into strongly fluorescent Mem-Rhodamine. During transferrin-mediated endocytosis, Mem-RhoNox enters endosomes together with the transferrin-transferrin receptor complex, and reacts with Fe (II) released by transferrin to enable detection of endosomal Fe (II) .
Cat. No.: HY-D3128
CAS No.: 2348351-60-8
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Mito-RhFe is a Fluorescent probe for mitochondrial labile Fe³⁺ monitoring via imaging and flow cytometry. This probe is a rhodamine-based construct with a spirolactam fluorescence signaling group and an N2-hydroxyethyldiethylenetriamine chelator; its delocalized positive charge enables mitochondria-targeting ability in live cells, and it exhibits fine cell membrane permeability. In its native state, it exists in the non-fluorescent spirolactam form, but upon binding to Fe³⁺, it undergoes a ring-opening conversion to the fluorescent rhodamine form, triggering a turn-on fluorescent response; this process is reversible, as the addition of the metal chelator TPEN removes Fe³⁺ and converts the probe back to its non-fluorescent spirolactam form, and re-addition of Fe³⁺ restores fluorescence. The probe shows high selectivity for Fe³⁺ over most other metal cations present in living systems, with a ~90-fold fluorescence enhancement upon binding to 20 equiv of Fe³⁺. Mito-RhFe has excitation/emission wavelengths of Ex/Em = 540/578 nm, with an ~8 nm bathochromic shift in emission upon Fe³⁺ binding, and it can also be excited at 543 nm for confocal imaging with emission detected at 570-620 nm[1].
Cat. No.: HY-D3377
CAS No.: 1616953-95-7
Synonyms: LysoRhoNox
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HMRhoNox-M (LysoRhoNox) is a selective fluorescent probe for detecting Fe 2+ (ferrous iron ions), with excitation/emission wavelengths of Ex/Em = 550/575 nm. HMRhoNox-M exists in a non-fluorescent spirocyclic closed conformation under physiological pH conditions. Fe 2+ triggers the deoxidation of its N-oxide group, shifting the equilibrium toward the fluorescent quinone-type (TMHMR) open conformation. HMRhoNox-M shows selectivity for Fe 2+ over other metal ions, as well as biologically relevant reactive oxygen species, reactive sulfur species, reactive nitrogen species and reducing agents. HMRhoNox-M can penetrate cell membranes and localize to lysosomes, enabling the imaging of intracellular Fe 2+ fluctuations, transferrin-mediated labile iron accumulation, and lysosomal Fe 2+ changes associated with ferroptosis .
Cat. No.: HY-184643
Manganese zinc ferrite is a complex metal oxide composed of oxides of manganese (Mn), zinc (Zn), and iron (Fe). It has a spinel structure and its chemical formula is usually represented as (Zn,Mn)Fe2O4.
Cat. No.: HY-182300
CAS No.: 171092-64-1
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FE 999011 is an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with IC50 values of 7 nM and 3 nM against human and rat sources, respectively. FE 999011 acts as a glucose tolerance-improving agent and a GLP-1 receptor activator, which reduces blood glucose fluctuation, promotes GLP-1 release and decreases the insulin-glucose ratio. FE 999011 regulates lipid metabolism, delays the onset of diabetes, stabilizes food and water intake, reduces hypertriglyceridemia, prevents the elevation of free fatty acids, and delays the progression of impaired glucose tolerance to disease. FE 999011 can be used in relevant studies of type 2 diabetes .
Cat. No.: HY-E71099
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(R)-Dichlorprop dioxygenase (2-oxoglutarate) (EC 1.14.11.44) is a Fe2+-dependent enzyme. (R)-Dichlorprop dioxygenase (2-oxoglutarate) (EC 1.14.11.44) is involved in the degradation of the (R)-enantiomer of the phenoxyalkanoic acid herbicides mecoprop and dichlorprop.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
