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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
123 Results for "
SAM
" in MedChemExpress (MCE) Product Catalog:
Products (123)
123 Results for "SAM" in MCE Product Catalog:
Cat. No.: HY-E71766
Target:
Domaines de recherche:
3-Methylquercetin 7-O-methyltransferase (EC 2.1.1.82) is a SAM-dependent O-methyltransferase (OMT) that catalyzes the methylation of the 7-O-hydroxyl group of flavonols.
Cat. No.: HY-104009AR
CAS No.: 2245255-66-5
Domaines de recherche:
GSK2807 Trifluoroacetate (Standard) is the analytical standard of GSK2807 Trifluoroacetate (HY-104009A). This product is intended for research and analytical applications. GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM and an IC50 of 130 nM .
Cat. No.: HY-180816
CAS No.: 303969-88-2
Target:
Domaines de recherche:
PRMT5-MTA-IN-7 (Compound 14) is a selective PRMT5-MTA inhibitor. PRMT5-MTA-IN-7 exhibits KD values of PRMT5-MTA-IN-7 for PRMT5-MTA and PRMT5-SAM of 236 nM and 2.84 μM respectively, and the IC50 values of 4.08 and 13.6 μM respectively. PRMT5-MTA-IN-7 can selectively inhibit the proliferation of MTAP-deficient cancer cells. PRMT5-MTA-IN-7 can be used for the study of colon cancer .
Cat. No.: HY-E71221
Target:
Domaines de recherche:
α-D-Ribose 1-methylphosphonate 5-phosphate C-P-lyase (EC 4.7.1.1) can be isolated from Escherichia coli and involves the [4Fe-4S] cluster and S-adenosyl-L-methionine (SAM) radical.
Cat. No.: HY-181333
CAS No.: 2653338-74-8
Target:
Domaines de recherche:
PROTAC EZH2 Degrader-38 (Compound 17) is a EZH2 PROTAC degrader with an IC50 of 165.00 nM. PROTAC EZH2 Degrader-38 functionally inhibits the methyltransferase activity of EZH2 and competitively binds to the SAM-binding pocket of the EZH2 SET domain .
Cat. No.: HY-P703313
Pureté: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: SAMHD1; DNTPase; SAM And HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase 1; HSAMHD1; MOP-5; Mg11; Deoxynucleoside Triphosphate Triphosphohydrolase SAMHD1; AGS5; SAM Domain And HD Domain-Containing Protein 1; DCIP; Monocyte Protein 5
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-E71453E
Target:
Domaines de recherche:
23S rRNA (adenosine-1067-2'-O)-methyltransferase (EC 2.1.1.230) is a methyltransferase that utilizes S-adenosylmethionine (SAM) as a methyl donor to methylate the 2'-hydroxyl group of the ribose at position A1067 of bacterial 23S rRNA, thereby conferring resistance to thiopeptide antibiotics.
Cat. No.: HY-100846R
CAS No.: 1913252-04-6
Domaines de recherche:
JQEZ5 (Standard) is the analytical standard of JQEZ5 (HY-100846). This product is intended for research and analytical applications. JQEZ5 is a potent and selective EZH2 lysine methyltransferase inhibitor. JQEZ5 SAM-competitively inhibits polycomb repressive complex 2 (PRC2) with an IC50 of 80 nM. JQEZ5 has anti-tumor effects .
Cat. No.: HY-180846
CAS No.: 3119375-08-2
Target:
Domaines de recherche:
NT32 is a selective METTL13 stabilizer with a Kd value of 14 μM. NT32 could occupy both the SAM/SAH-binding pocket and the peptide substrate-binding site of METTL13 simultaneously. NT32 specifically targets and stabilizes METTL13. NT32 shows no inhibitory activity against non-small cell lung cancer .
Cat. No.: HY-185849
CAS No.: 2585194-96-1
Target:
Domaines de recherche:
SETDB1-IN-1 is a SETDB1 inhibitor with an IC50 of 16 μM. SETDB1-IN-1 inhibits histone methyltransferase) activity via SAM-competitive and peptide-dependent mechanisms. SETDB1-IN-1 is applicable to research related to melanoma, lung cancer, liver cancer, breast cancer and prostate cancer .
Cat. No.: HY-P87064
Synonyms: CGI 51 antibody; CGI-51 antibody; FLJ35825 antibody; FLJ42905 antibody; FLJ99036 antibody; OMP85 antibody; SAM50 antibody; SAM50_HUMAN antibody; SAMm50 antibody; sorting and assembly machinery 50kDa antibody; CGI 51 antibody; CGI-51 antibody; FLJ35825 antibody; FLJ42905 antibody; FLJ99036 antibody; OMP85 antibody; SAM50 antibody; SAM50_HUMAN antibody; SAMm50 antibody; sorting and assembly machinery 50kDa antibody; sorting and assembly machinery component 50 homolog (S. cerevisiae) antibody; Sorting and assembly machinery component 50 homolog antibody; sorting and assembly machinery component 50, S. cerevisiae, homolog of antibody; TOB55 antibody; Transformation-related gene 3 protein antibody; TRG-3 antibody; YNL026W antibody;
Cat. No.: HY-P810312
Synonyms: CGI 51 antibody; CGI-51 antibody; FLJ35825 antibody; FLJ42905 antibody; FLJ99036 antibody; OMP85 antibody; SAM50 antibody; SAM50_HUMAN antibody; SAMm50 antibody; sorting and assembly machinery 50kDa antibody; CGI 51 antibody; CGI-51 antibody; FLJ35825 antibody; FLJ42905 antibody; FLJ99036 antibody; OMP85 antibody; SAM50 antibody; SAM50_HUMAN antibody; SAMm50 antibody; sorting and assembly machinery 50kDa antibody; sorting and assembly machinery component 50 homolog (S. cerevisiae) antibody; Sorting and assembly machinery component 50 homolog antibody; sorting and assembly machinery component 50, S. cerevisiae, homolog of antibody; TOB55 antibody; Transformation-related gene 3 protein antibody; TRG-3 antibody; YNL026W antibody;
Cat. No.: HY-E71453C
Target:
Domaines de recherche:
23S rRNA (adenine2503-C2)-methyltransferase (EC 2.1.1.192) contains a [4Fe-4S] cluster and belongs to the "radical AdoMet" (radical SAM) family. It employs a radical-based mechanism to methylate the adenosine residue using a CH? group derived from S-adenosyl-L-methionine, while retaining the hydrogen atom at the C-2 position of adenosine 2503 in the 23S rRNA.
Cat. No.: HY-182021
CAS No.: 3124204-81-2
Target:
Domaines de recherche:
NNMT-IN-8 is a non-SAM-mimicking bisubstrate inhibitor and a selective methyltransferase NNMT inhibitor, with IC50 values of 0.0084 μM and 0.0085 μM against human NNMT, and an IC50 of 0.0072 μM against mouse NNMT. NNMT-IN-8 exhibits prominent renal distribution characteristics and moderate bioavailability in rodents. NNMT-IN-8 dose-dependently inhibits renal NNMT in renal fibrosis models, thereby exerting antifibrotic effects. NNMT-IN-8 can be used to investigate the mechanisms of renal fibrosis .
Cat. No.: HY-183568
Domaines de recherche:
MAT2A-IN-26 is an orally active MAT2A inhibitor with a human IC50 of 17.53 nM. MAT2A-IN-26 inhibits the enzymatic activity of MAT2A, thereby reducing the levels of S-adenosylmethionine (SAM) and symmetric dimethylarginine (sDMA). MAT2A-IN-26 inhibits the proliferation of MTAP-deficient cancer cells and induces anti-tumor efficacy in xenograft models. MAT2A-IN-26 can be used in non-small cell lung cancer research .
Cat. No.: HY-184653
Target:
Domaines de recherche:
MS3-123 is an orally active PRMT1 inhibitor (IC50 = 11.4 nM) that selectively targets the unique Cys119 residue within the SAM-binding pocket. MS3-123 covalently binds to PRMT1 through a time-dependent irreversible mechanism and exhibits high selectivity over other PRMT family members and other methyltransferases. MS3-123 inhibits breast cancer cell proliferation, migration and invasion, and induces cell cycle arrest and apoptosis. MS3-123 is useful for breast cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
