2245255-66-5
2245255-66-5
Chemical Structure
GSK2807 Trifluoroacetate
- CAS No.: 2245255-66-5
- Formula:C21H33F3N8O7
- Molecular Weight:566.53
IUPAC Name: (S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(3-(dimethylamino)propyl)amino)butanoic acid compound with 2,2,2-trifluoroacetic acid (1:1)
InChIKey: FZPZIBBKUWOBTJ-CPQMNCBCSA-N
SMILES: NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CN(CC[C@H](N)C(O)=O)CCCN(C)C)O3)C=N2)=NC=N1.OC(C(F)(F)F)=O
Biological Activity: GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM and an IC50 of 130 nM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GSK2807 Trifluoroacetate | 99.83% | GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM and an IC50 of 130 nM. | ||||||||||||||||||||
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GSK2807 Trifluoroacetate (Standard) | ≥98% | GSK2807 Trifluoroacetate (Standard) is the analytical standard of GSK2807 Trifluoroacetate (HY-104009A). This product is intended for research and analytical applications. GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM and an IC50 of 130 nM. | ||||||||||||||||||||
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References
- [1]. Van Aller GS, et al. Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure. 2016 May 3;24(5):774-781. [Content Brief]
- [2]. Kaniskan HÜ, et al. Inhibitors of Protein Methyltransferases and Demethylases. Chem Rev. 2018 Feb 14;118(3):989-1068. [Content Brief]
