1. Epigenetics
  2. Histone Methyltransferase

GSK2807 Trifluoroacetate 

Cat. No.: HY-104009A Purity: 95.24%
Handling Instructions

GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM.

For research use only. We do not sell to patients.

GSK2807 Trifluoroacetate Chemical Structure

GSK2807 Trifluoroacetate Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 312 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
25 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM.

IC50 & Target[1]

SMYD3

14 nM (Ki)

In Vitro

A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 is 24-fold selective for SMYD3 in comparison with the closely related enzyme SMYD2 (Ki=14±6 nM and 345±36 nM, respectively)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7651 mL 8.8257 mL 17.6513 mL
5 mM 0.3530 mL 1.7651 mL 3.5303 mL
10 mM 0.1765 mL 0.8826 mL 1.7651 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

566.53

Formula

C₂₁H₃₃F₃N₈O₇

SMILES

NC1=C2C(N([[email protected]]3[[email protected]](O)[[email protected]](O)[[email protected]@H](CN(CC[[email protected]](N)C(O)=O)CCCN(C)C)O3)C=N2)=NC=N1.OC(C(F)(F)F)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

Product Name:
GSK2807 Trifluoroacetate
Cat. No.:
HY-104009A
Quantity:

GSK2807 Trifluoroacetate

Cat. No.: HY-104009A