2. Metabolic Enzyme/Protease
  3. Amine N-methyltransferase
  4. NNMT-IN-6

NNMT-IN-6 is a selective nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.41 μM and a Kd of 5.55 μM. NNMT-IN-6 hydrochloride exhibits selectivity over PRMT1 and NSD2. NNMT-IN-6 inhibits cancer cell proliferation and reduces cellular N-methylnicotinamide (MNA) production. NNMT-IN-6 can be used for the research of oral cancer.

For research use only. We do not sell to patients.

NNMT-IN-6

NNMT-IN-6 Chemical Structure

CAS No. : 2368247-39-4

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Based on 1 publication(s) in Google Scholar

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NNMT-IN-6 Related Antibodies

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Description

NNMT-IN-6 is a selective nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.41 μM and a Kd of 5.55 μM. NNMT-IN-6 hydrochloride exhibits selectivity over PRMT1 and NSD2. NNMT-IN-6 inhibits cancer cell proliferation and reduces cellular N-methylnicotinamide (MNA) production. NNMT-IN-6 can be used for the research of oral cancer[1].

IC50 & Target[1]

NNMT

1.41 μM (IC50)

NNMT

5.55 μM (Kd)

In Vitro

NNMT-IN-6 (compound 78) (10-100 μM; 24-72 h) dose- and time- dependently inhibits HSC-2 human oral cancer cell proliferation[1].
NNMT-IN-6 (100 μM; 0-72 h) inhibits cellular NNMT activity in HSC-2 human oral cancer cells, reducing MNA production by 50% at 100 μM after 48 h[1].
NNMT-IN-6 binds the NNMT active site, forms π-π stacking interactions with tyrosine residues in the nicotinamide binding pocket, and forms an intramolecular hydrogen bond that stabilizes its binding conformation.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NNMT-IN-6 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HSC-2 cells
Concentration: 1; 10; 50; 100 μM
Incubation Time: 24; 48; 72 h
Result: Caused a significant 20% reduction in cell proliferation at 10 μM after 48 h.
Caused a significant 21% reduction in cell proliferation at 50 μM after 48 h.
Caused a significant 27% reduction in cell proliferation at 100 μM after 48 h.
Caused a significant 44% reduction in cell proliferation at 100 μM after 72 h.
Dose dependently inhibited HSC-2 cell proliferation.
Showed no inhibition activity at 24 h.
Molecular Weight

507.54

Formula

C25H29N7O5
CAS No.
SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CN(CC(C=C4)=CC5=C4C=CC=C5)CC[C@@H](C(O)=O)N)O3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NNMT-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NNMT-IN-62368247-39-4Amine N-methyltransferaseoral cancerHSC-2 human oral cancer cellnicotinamide N-methyltransferasePRMT1N-methylnicotinamideNNMTNSD2tyrosine residuesInhibitorinhibitorinhibit

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