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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
116 Results for "
SN2
" in MedChemExpress (MCE) Product Catalog:
Products (116)
116 Results for "SN2" in MCE Product Catalog:
Cat. No.: HY-157693
CAS No.: 799268-69-2
Target:
Research Areas:
C18:1 Cyclic LPA is a naturally occurring analog of the growth factor-like phospholipid mediator, lysophosphatidic acid (LPA), characterized by the formation of a 5-membered ring between its sn-2 hydroxy group and the sn-3 phosphate. This unique structure allows C18:1 Cyclic LPA to influence a variety of cellular functions, such as inhibiting cell cycle progression, promoting the formation of stress fibers, curtailing tumor cell invasiveness and metastasis, and modulating the differentiation and survival of neuronal cells. Notably, many of these cellular effects elicited by C18:1 Cyclic LPA appear to counter those induced by LPA, despite the activation of seemingly similar receptor populations.
Cat. No.: HY-168371
CAS No.: 161923-56-4
Research Areas:
1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC (13-HODE-PC) is an oxidized phospholipid that contains Palmitic acid (HY-N0830) and 13(S)-HODE (HY-113884B) at the sn-1 and sn-2 positions, respectively. 1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC has the ability to compete for the binding of 125I-NO2-LDL (5 g/mL) to CD36-transfected 293 cells, with the IC50 of ＞ 200 μM .
Cat. No.: HY-W440983
CAS No.: 59403-52-0
Synonyms: PC(18:0/22:6); DHA-PC; 1-Stearoyl-2-docosahexaenoyl-SN-glyerco-3-phosphocholine
Target:
SDPC (DHA-PC) is a new generation of omega-3 lipids, which contains an ester bond linking DHA at the sn-2 position of phospholipid. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine exerts anti-angiogenesis effect through activating PPARγ. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine significantly declines the proliferation, migration, tube formation of human umbilical vein endothelial cells. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine has the potential for anti-tumor angiogenesis research .
Cat. No.: HY-145473
CAS No.: 947381-58-0
Synonyms: 15(S)-HETE-SAPE; 15(S)-Hydroxyeicosatetraenoic acid-SAPE; 1-Stearoyl-2-15(S)-HETE-SN-glycero-3-Phosphatidylethanolamine
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1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE (15(S)-HETE-SAPE) is a phospholipid containing stearic acid (HY-B2219) at the sn-1 position and 15(S)-HETE (HY-113336) at the sn-2 position. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is formed by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE) by 15-LOX in human peripheral mononuclear cells activated with the calcium ionophore A23187 (HY-N6687).
Cat. No.: HY-145504
CAS No.: 344791-14-6
Synonyms: 1,2-Palmitin-3-Linoelaidin
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Research Areas:
12-Dipalmitoyl-3-Linoelaidoyl-rac-glycerol is a triacylglycerol containing palmitic acid (HY-N0830) at the sn-1 and sn-2 positions and linoelaidic acid (HY-W071746) at the sn-3 position. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Linolelaidic acid, an omega-6 trans fatty acid, acts as a source of energy. Linolelaidic acid is an essential nutrient, adding in enteral, parenteral, and infant formulas. Linolelaidic acid can be used for heart diseases research [2] .
Cat. No.: HY-W127357
CAS No.: 126-53-4
Cat. No.: HY-112747
CAS No.: 97281-51-1
Synonyms: LPI; PE (soy)
Target:
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Soy PE (LPI) is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids. In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It is synthesized mainly through the cytidine diphosphate-ethanolamine and phosphatidylserine decarboxylation pathways, which occur in the endoplasmic reticulum (ER) and mitochondrial membranes, respectively. It is a precursor in the synthesis of phosphatidylcholine and arachidonoyl ethanolamide and is a source of ethanolamine used in various cellular functions. In E.coli, phosphatidylethanolamine deficiency prevents proper assembly of lactose permease, suggesting a role as a lipid chaperone. It is a cofactor in the propagation of prions in vitro and can convert recombinant mammalian proteins into infectious molecules even in the absence of RNA. This product contains phosphatidylethanolamine molecular species with variable fatty acyl chain lengths at the sn-1 and sn-2 positions .
Cat. No.: HY-115701
CAS No.: 154436-49-4
Synonyms: 1-Stearoyl-2-15(S)-HpETE-SN-glycero-3-phosphoethanolamine; 15(S)-HpETE-SAPE; 15(S)-hydroperoxyeicostetraenoic acid-SAPE
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Research Areas:
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.
Cat. No.: HY-141636S
CAS No.: 1872379-11-7
Synonyms: 1-Palmitoyl-2-arachidonoyl-SN-glycero-3-phosphocholine-d9-1; PAPC-d9-1; PC(16:0/20:4)-d9-1
Cat. No.: HY-W127391
CAS No.: 17598-94-6
Synonyms: (Rac)-1,2-Didodecanoylglycerol
Cat. No.: HY-W010736A
CAS No.: 40290-32-2
Cat. No.: HY-145473S
Synonyms: 15(S)-HETE-SAPE; 15(S)-Hydroxyeicosatetraenoic acid-SAPE-d11; 1-Stearoyl-2-15(S)-HETE-SN-glycero-3-Phosphatidylethanolamine-d11
Cat. No.: HY-RS13223
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Research Areas:
SLC38A5 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC38A5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-141631
CAS No.: 155575-01-2
Synonyms: L-α-Phosphatidylcholine
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Research Areas:
Phospholipase A2 (PLA2), Crotalus adamanteus Venom is a membrane phospholipid-targeting enzyme. Phospholipase A2, Crotalus adamanteus catalyzes cleavage of the sn-2-acyl bond of membrane phospholipids, producing lysophospholipids and free fatty acids. Phospholipase A2, Crotalus adamanteus Venom can be used for biochemical research [2] .
Cat. No.: HY-W096441
CAS No.: 106006-84-2
Synonyms: Pramipexole impurity E
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Research Areas:
(S)-N-(2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionamide (Pramipexole propionamide) is a drug impurity.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
