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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
125 Results for "
Sec
" in MedChemExpress (MCE) Product Catalog:
Products (125)
125 Results for "Sec" in MCE Product Catalog:
Cat. No.: HY-P78774
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MUC1; Mucin Short Variant E1; Prev. PUM; MUC1 Isoform SV7-LSP; Prev. MCKD1; MUC1 Isoform J18; KL-6; MUC1 Isoform J16; PEM; MUC1 Isoform J15; EMA; MUC1 Isoform J24; ADMCKD1; MUC1 Isoform T12; Mucin-1; MUC1 Isoform T13; ADMCKD; MUC1 Isoform M11; Ca15-3; MUC
Species:
Human
Source:
HEK293
Cat. No.: HY-P703262
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CYTH2; Pleckstrin Homology, Sec7 And Coiled/Coil Domains 2 (Cytohesin-2); Prev. PSCD2; ARF Nucleotide-Binding Site Opener; Prev. PSCD2L; ARF Exchange Factor; Cytohesin-2; Pleckstrin Homology, Sec7 And Coiled-Coil Domains 2 (Cytohesin-2), Isoform CRA_c; AR
Species:
Human
Source:
E. coli
Cat. No.: HY-P78734
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MUC1; Mucin Short Variant E1; Prev. PUM; MUC1 Isoform SV7-LSP; Prev. MCKD1; MUC1 Isoform J18; KL-6; MUC1 Isoform J16; PEM; MUC1 Isoform J15; EMA; MUC1 Isoform J24; ADMCKD1; MUC1 Isoform T12; Mucin-1; MUC1 Isoform T13; ADMCKD; MUC1 Isoform M11; Ca15-3; MUC
Species:
Human
Source:
HEK293
Cat. No.: HY-162006
CAS No.: 916038-47-6
Research Areas:
Pim-1 kinase inhibitor 8 is a potent PIM-1 inhibitor with an IC50 value of 14.3 nM. Pim-1 kinase inhibitor 8 impedes cell proliferation and migration through PIM-1 inhibition and the induction of both apoptosis and autophagy. Pim-1 kinase inhibitor 8 inhibits solid tumor growth in Solid Ehrlich Carcinoma (SEC)-bearing mice. Pim-1 kinase inhibitor 8 can be used for breast and liver cancer research .
Cat. No.: HY-P78733
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MUC1; Mucin Short Variant E1; Prev. PUM; MUC1 Isoform SV7-LSP; Prev. MCKD1; MUC1 Isoform J18; KL-6; MUC1 Isoform J16; PEM; MUC1 Isoform J15; EMA; MUC1 Isoform J24; ADMCKD1; MUC1 Isoform T12; Mucin-1; MUC1 Isoform T13; ADMCKD; MUC1 Isoform M11; Ca15-3; MUC
Species:
Human
Source:
HEK293
Cat. No.: HY-P78833
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MUC1; Mucin Short Variant E1; Prev. PUM; MUC1 Isoform SV7-LSP; Prev. MCKD1; MUC1 Isoform J18; KL-6; MUC1 Isoform J16; PEM; MUC1 Isoform J15; EMA; MUC1 Isoform J24; ADMCKD1; MUC1 Isoform T12; Mucin-1; MUC1 Isoform T13; ADMCKD; MUC1 Isoform M11; Ca15-3; MUC
Species:
Human
Source:
HEK293
Cat. No.: HY-P77092
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: STXBP1; NSec1; Syntaxin Binding Protein 1; Unc-18A; Syntaxin-Binding Protein 1; Unc18-1; MUNC18-1; HUNC18; Protein Unc-18 Homolog 1; P67; Protein Unc-18 Homolog A; Neuronal Sec1; RbSec1; UNC18A; N-Sec1; DEE4; UNC18
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-122802
CAS No.: 1838592-80-5
Research Areas:
TPP2a bromide is a thioredoxin reductase (TrxR) inhibitor with an IC50 value of 1.16 μM, and also acts as a TrxR-specific fluorescent probe with environment-sensitive fluorescence. TPP2a bromide selectively forms covalent interactions with subcellular mitochondrial TrxR, thereby modifying its Sec498 residue. TPP2a bromide can increase the level of reactive oxygen species (ROS) in cells and induce mitochondrial apoptosis in cancer cells. TPP2a bromide exhibits enhanced cytotoxicity against cancer cell lines. TPP2a bromide can be used in research related to cervical cancer, lung cancer, etc .
Cat. No.: HY-178364
CAS No.: 3102894-57-2
Target:
Glutathione Peroxidase Ferroptosis Lipoxygenase Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Research Areas:
GPX4-IN-19 is an effective GPX4 inhibitor (IC50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4. GPX4-IN-19 shows strong anti-proliferative activity with high ferroptosis selectivity. GPX4-IN-19 causes intracellular Fe 2+ accumulation, leading to increased levels of lipid peroxides (LPOs) and reactive oxygen species (ROS), which induces ferroptosis and subsequently results in DNA damage. GPX4-IN-19 can be used for the study of Triple-Negative Breast Cancer (TNBC) .
Cat. No.: HY-182674
CAS No.: 1322645-32-8
Target:
VGD020 is a highly potent and selective Sec61 translocon inhibitor . VGD020 suppresses the expression of cell surface CD4 by inhibiting signal peptide-dependent co-translational ER translocation, interferes with the initiation of ER translocation of dengue virus polyprotein, and reduces the expression of Sortilin in breast cancer cells. VGD020 exhibits broad anti-flavivirus and anti-HIV activities. VGD020 can be used in research related to dengue virus infection, Zika virus infection, yellow fever virus infection, human immunodeficiency virus infection, and breast cancer .
Cat. No.: HY-110078R
CAS No.: 412960-54-4
Target:
Research Areas:
Eeyarestatin I (Standard) is the analytical standard of Eeyarestatin I (HY-110078). This product is intended for research and analytical applications. Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects .
BQU57 is a selective inhibitor of RalA/RalB small GTPases, with a binding potency (Kb) of 7.7 μM for RalB-GDP. BQU57 can block its interaction with effector proteins (such as SEC5 and EXO84), inhibiting tumor cell migration, invasion and non-adherent growth. BQU57 downregulates the NF-κB signaling pathway, reduces the expression of IL-6, IL-8 and MMP-13, and inhibits apoptosis by regulating the Bcl-2/Bax balance. BQU57 also protects the extracellular matrix by inhibiting the Ral/NF-κB pathway and can be used for the study of degenerative diseases. BQU57 exhibits significant antitumor activity in triple-negative breast cancer (TNBC) models, inhibiting orthotopic tumor growth and lung metastasis and enhancing paclitaxel chemotherapy sensitivity .
Cat. No.: HY-187361
CAS No.: 3107740-33-7
PROTAC HIV-1 degrader-1 is a HIV-1 capsid (CA) PROTAC degrader, with a DC50 of 3 nM against HIV-1IIIB (MT‑4 cells) and a DC50 of 1.17 nM against HIV-1NL4-3 (MT‑4 cells). PROTAC HIV-1 degrader-1 conjugates HIV-1 capsid (CA) with the VHL E3 ubiquitin ligase, triggering polyubiquitination and proteasome-mediated degradation of CA, as well as competitively inhibiting the binding of host factors CPSF6 and Sec24C to CA. PROTAC HIV-1 degrader-1 degrades CA drug-resistant mutants (N74D, K70R). PROTAC HIV-1 degrader-1 is applicable to research related to HIV-1 infection .
Cat. No.: HY-P74535
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: STXBP3; Unc18-3; Syntaxin Binding Protein 3; PSP; UNC-18C; Syntaxin 4 Binding Protein; Syntaxin-Binding Protein 3; MUNC18-3; Protein Unc-18 Homolog 3; MUNC18C; Protein Unc-18 Homolog C; Unc-18C; Platelet Sec1 Protein
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P77914
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: DLK1; DLK; Delta Like Non-Canonical Notch Ligand 1; Delta-Like 1 Homolog (Drosophila); PG2; Delta-Like Homolog (Drosophila); Protein Delta Homolog 1; Preadipocyte Factor 1; Pref-1; Delta-Like 1 Homolog; Delta1; Fetal Antigen 1; FA1; Delta-Like 1; ZOG; Sec
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
