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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
126 Results for "
OX2R knockout
" in MedChemExpress (MCE) Product Catalog:
Products (126)
126 Results for "OX2R knockout" in MCE Product Catalog:
Cat. No.: HY-13757R
CAS No.: 54965-24-1
Synonyms: ICI 46474 (Standard); (Z)-TamOXifen Citrate (Standard); trans-TamOXifen Citrate (Standard)
Research Areas:
Tamoxifen (Citrate) (Standard) is the analytical standard of Tamoxifen (Citrate). This product is intended for research and analytical applications. Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells [2] .Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .
Cat. No.: HY-13757S
Purity: 98.99%
Synonyms: ICI 46474-d3 hydrochloride; (Z)-TamOXifen-d3 hydrochloride; trans-TamOXifen-d3 hydrochloride
Cat. No.: HY-159190
CAS No.: 2409140-12-9
Target:
Research Areas:
HRX-0233 is an orally potent MAP2K4 inhibitor. HRX-0233 inhibits the MAP2K4-JNK-JUN signaling pathway, blocks the feedback activation of receptor tyrosine kinases, and sustains the inhibitory effect on KRAS signaling. HRX-0233 exerts synergistic inhibition on the mTORC1 and MAPK pathways. When combined with Ipatasertib (HY-15186) or Sotorasib (HY-114277), it produces synergistic antiproliferative, pro-apoptotic (apoptosis) and antitumor effects, and shows good tolerability in mouse models. HRX-0233 can be used in CRISPR knockout screens to identify vulnerability-related genes. HRX-0233 is applicable to research related to prostate cancer, non-small cell lung cancer and colorectal cancer [2].
Cat. No.: HY-13757AS2
CAS No.: 3047060-10-3
Synonyms: ICI 47699-d2; (Z)-TamOXifen-d2; trans-TamOXifen-d2
Cat. No.: HY-P4087
CAS No.: 1417221-06-7
Cat. No.: HY-P4087B
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
