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製品番号: HY-13757AS2

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Tamoxifen-d₂

(別名: ICI 47699-d₂; (Z)-Tamoxifen-d₂; trans-Tamoxifen-d₂)

Tamoxifen-d₂ (ICI 47699-d₂) is the deuterium labeled Tamoxifen (HY-13757A). Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3047060-10-3
分子式: C₂₆H₂₇D₂NO
分子量:373.53

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tamoxifen-d₂ 構造式

CAS 番号: 3047060-10-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

HSP アイソフォーム固有の製品をすべて表示 :

Estrogen Receptor/ERR アイソフォーム固有の製品をすべて表示 :

体外実験

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

アプリケーション

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

化学情報

CAS 番号 3047060-10-3
非標識Cas 10540-29-1
分子量 373.53
分子式 C₂₆H₂₇D₂NO
SMILES

CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC([2H])=C(C([2H])=C3)OCCN(C)C
別名

ICI 47699-d₂; (Z)-Tamoxifen-d₂; trans-Tamoxifen-d₂
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.