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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
164 Results for "
interferon alpha
" in MedChemExpress (MCE) Product Catalog:
Products (164)
164 Results for "interferon alpha" in MCE Product Catalog:
Cat. No.: HY-P86157
Synonyms: EIF2AK2; PKR; PRKR; interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k
Cat. No.: HY-114216
CAS No.: 1310694-75-7
Target:
Research Areas:
DBPR110 is a nonstructural protein 5A (NS5A) inhibitor with inhibitory activity against hepatitis C virus (HCV). DBPR110 exhibited a 50% effective concentration (EC50) of 3.9 ± 0.9 pM and a selectivity index value of over 12,800,000 by reducing HCV1b replicon reporter expression. DBPR110 also effectively reduced the activity of HCV2a replicon with an EC50 of 228.8 pM and a selectivity index value of over 173,130. DBPR110 showed synergy with interferon alpha (IFN-α), NS3 protease inhibitors, and NS5B polymerase inhibitors. The results of DBPR110 suggest that it may be an effective small molecule inhibitor against HCV NS5A .
Cat. No.: HY-131920
CAS No.: 27416-86-0
Synonyms: Polyuridylic acid
Cat. No.: HY-P703281
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IRF9; interferon-Stimulated Transcription Factor 3, Gamma (48kD); Prev. ISGF3G; ISGF-3 Gamma; IFN-alpha-Responsive Transcription Factor Subunit; IRF-9; Transcriptional Regulator ISGF3 Subunit Gamma; ISGF3; interferon-Stimulated Gene Factor 3 Gamma; P48; I
Species:
Human
Source:
E. coli
Cat. No.: HY-P703283
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: IRF9; interferon-Stimulated Transcription Factor 3, Gamma (48kD); Prev. ISGF3G; ISGF-3 Gamma; IFN-alpha-Responsive Transcription Factor Subunit; IRF-9; Transcriptional Regulator ISGF3 Subunit Gamma; ISGF3; interferon-Stimulated Gene Factor 3 Gamma; P48; I
Species:
Human
Source:
E. coli
Cat. No.: HY-P81299
Synonyms: EIF2AK2; PKR; PRKR; interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k
Cat. No.: HY-P81299A
Synonyms: EIF2AK2; PKR; PRKR; interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k
Cat. No.: HY-P703282
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IRF9; interferon-Stimulated Transcription Factor 3, Gamma (48kD); Prev. ISGF3G; ISGF-3 Gamma; IFN-alpha-Responsive Transcription Factor Subunit; IRF-9; Transcriptional Regulator ISGF3 Subunit Gamma; ISGF3; interferon-Stimulated Gene Factor 3 Gamma; P48; I
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P75990
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PSME1; IGUP I-5111; Proteasome Activator Subunit 1; Epididymis Secretory Sperm Binding Protein Li 129m; PA28alpha; interferon-Gamma-Inducible Protein 5111; IFI5111; interferon-Gamma IEF SSP 5111; Activator Of Multicatalytic Protease Subunit 1; 29-KD MCP A
Species:
Human
Source:
E. coli
Cat. No.: HY-P81299AA
Synonyms: EIF2AK2; PKR; PRKR; interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k
Cat. No.: HY-177338
CAS No.: 2361424-97-5
Research Areas:
STING agonist-45 is a selective STING agonist (EC50 = 0.28 μM). STING agonist-45 activates the innate immune response through the cGAS-STING pathway, upregulating key markers such as p-TBK1 and IRF3. STING agonist-45 exhibits robust STING activation in human peripheral blood mononuclear cells (PBMCs), inducing the production of type I interferons (such as IFN-β) and downstream cytokines (such as TNF-α and IL-6). STING agonist-45 enhances anti-tumor immunity, inhibits tumor growth, and increases CD8 + T cell infiltration in mouse models. STING agonist-45 is promising for the study of STING-related diseases .
Cat. No.: HY-P705639
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IL6; Hybridoma Growth Factor; Prev. IFNB2; IFN-Beta-2; IL-6; BSF-2; Interleukin-6; CDF; BSF2; Interleukin 6 (interferon, Beta 2); HGF; B-Cell Differentiation Factor; HSF; Truncated Interleukin 6; B-Cell Stimulatory Factor 2; interferon, Beta 2; CTL Differ
Species:
Human
Source:
HEK293
Cat. No.: HY-P702986
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: STAT2; Signal Transducer And Activator Of Transcription 2, 113kD; Signal Transducer And Activator Of Transcription 2; interferon alpha Induced Transcriptional Activator; STAT113; Signal Transducer And Activator Of Transcription; Signal Transducer And Acti
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P990233
Target:
Research Areas:
Cat. No.: HY-P705041
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNLR1; IFN-Lambda Receptor 1; Prev. IL28RA; IL-28R-alpha; CRF2/12; CRF2-12; IL-28R1; IL-28RA; IFNLR; LICR2; Interleukin 28 Receptor, alpha (interferon, Lambda Receptor); Class II Cytokine Receptor CRF2/12; Likely Interleukin Or Cytokine Receptor 2; Inter
Species:
Human
Source:
HEK293
Cat. No.: HY-P703222
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HNF1A; HNF1 alpha A Splice Variant 3; Prev. TCF1; HNF1 alpha A Splice Variant 5; Prev. MODY3; HNF1 alpha A Splice Variant 6; LFB1; HNF1 alpha A Splice Variant 7; HNF1; HNF1 alpha A Splice Variant 8; Liver-Specific Transcription Factor LF-B1; HNF1 alpha B Splice Variant 5; Hepatocyte Nuclear Factor 1-alpha; HNF1 alpha B Splice Variant 3; HNF-1-alpha; HNF1 alpha B Splice Variant 6; HNF-1A; HNF1 alpha A Splice Variant 2; TCF-1; Hepatic Nuclear Factor 1; Transcription Factor 1, Hepatic LF-B1, Hepatic Nuclear Factor (HNF1), Albumin Proximal Factor, Isoform CRA_b; Albumin Proximal Factor; Transcription Factor 1, Hepatic; LF-B1, Hepatic Nuclear Factor (HNF1), Albumin Proximal Factor; Transcription Factor 1; interferon Production Regulator Factor; HNF1alpha; Transcription Factor 1, Hepatic; IDDM20; HNF1 alpha A Splice Variant 1; HNF1α; HNF1 Homeobox A; HNF1 alpha A Splice Variant 4
Species:
Human
Source:
E. coli
Cat. No.: HY-P705226
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IFNLR1; IFN-Lambda Receptor 1; Prev. IL28RA; IL-28R-alpha; CRF2/12; CRF2-12; IL-28R1; IL-28RA; IFNLR; LICR2; Interleukin 28 Receptor, alpha (interferon, Lambda Receptor); Class II Cytokine Receptor CRF2/12; Likely Interleukin Or Cytokine Receptor 2; Inter
Species:
Human
Source:
HEK293
Cat. No.: HY-170524
CAS No.: 3052313-73-9
Research Areas:
TDI-015051 is a highly selective, orally active antiviral agent that targets the coronavirus NSP14 guanine-N7 methyltransferase. TDI-015051 binds to substrates in a non-competitive manner and forms a stable ternary complex, precisely blocking the capping and methylation processes of viral mRNA. TDI-015051 potently inhibits a variety of coronaviruses (including SARS-CoV-2 and MERS). By impairing viral replication and translation and inducing a moderate type I interferon-mediated immune response, it significantly reduces pulmonary viral load and exhibits a synergistic effect with Nirmatrelvir (HY-138687). In addition, TDI-015051 does not inhibit non-coronavirus methyltransferases, and the drug-resistant mutations it induces impair viral fitness, demonstrating excellent antiviral properties and safety. TDI-015051 can be used for research on COVID-19 and the replication mechanism of coronaviruses .The IC50 values of TDI-015051 against SARS-CoV-2, α-hCoV-NL63, α-hCoV-229E, β-hCoV-MERS are 0.15 nM, 1.7 nM, 2.6 nM and 3.6 nM, respectively, and the Ka value against SARS-CoV-2 is 0.061 nM .
Cat. No.: HY-169853
CAS No.: 1189495-81-5
Target:
Research Areas:
M351-0056 is an orally active VISTA agonist with a Kd value of 12.60 μM. M351-0056 inhibits the activation of the JAK2-STAT2 pathway, reduces the phosphorylation levels of JAK2 and STAT2, and regulates type I interferon (IFN-I) and non-canonical NF-κB pathways. M351-0056 decreases the levels of cytokines (IFN-γ, IL-17A, TNF-α, IL-2 and IL-1β). M351-0056 improves imiquimod (HY-B0180)-induced psoriasis-like skin inflammation, reduces autoantibody levels, kidney damage and immune cell expansion in mice susceptible to chronic graft-versus-host disease and lupus, and delays the progression of systemic lupus erythematosus. M351-0056 can be used in research related to psoriasis-like dermatitis and systemic lupus erythematosus .
Cat. No.: HY-P5522
CAS No.: 877462-71-0
Synonyms: L-Ala-γ-D-Glu-meso-diaminopimelic acid
Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
