1189495-81-5
Chemical Structure
M351-0056
- CAS No.: 1189495-81-5
- Formula:C15H12BrFN2O2S3
- Molecular Weight:447.37
InChIKey: VWQLSIBNGFNHPL-UHFFFAOYSA-N
SMILES: O=S(NC1=CC=C(C=C1F)Br)(C2=C(C)SC(C3=CSC(C)=N3)=C2)=O
Biological Activity: M351-0056 is an orally active VISTA agonist with a Kd value of 12.60 μM. M351-0056 inhibits the activation of the JAK2-STAT2 pathway, reduces the phosphorylation levels of JAK2 and STAT2, and regulates type I interferon (IFN-I) and non-canonical NF-κB pathways. M351-0056 decreases the levels of cytokines (IFN-γ, IL-17A, TNF-α, IL-2 and IL-1β). M351-0056 improves imiquimod (HY-B0180)-induced psoriasis-like skin inflammation, reduces autoantibody levels, kidney damage and immune cell expansion in mice susceptible to chronic graft-versus-host disease and lupus, and delays the progression of systemic lupus erythematosus. M351-0056 can be used in research related to psoriasis-like dermatitis and systemic lupus erythematosus[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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M351-0056 | 99.48% | M351-0056 is an orally active VISTA agonist with a Kd value of 12.60 μM. M351-0056 inhibits the activation of the JAK2-STAT2 pathway, reduces the phosphorylation levels of JAK2 and STAT2, and regulates type I interferon (IFN-I) and non-canonical NF-κB pathways. M351-0056 decreases the levels of cytokines (IFN-γ, IL-17A, TNF-α, IL-2 and IL-1β). M351-0056 improves imiquimod (HY-B0180)-induced psoriasis-like skin inflammation, reduces autoantibody levels, kidney damage and immune cell expansion in mice susceptible to chronic graft-versus-host disease and lupus, and delays the progression of systemic lupus erythematosus. M351-0056 can be used in research related to psoriasis-like dermatitis and systemic lupus erythematosus. | ||||||||||||||||||||
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References
- [1]. Hu X, et al. M351-0056 is a novel low MW compound modulating the actions of the immune-checkpoint protein VISTA. Br J Pharmacol. 2021 Mar;178(6):1445-1458. [Content Brief]
- [2]. Yang L, et al. Imatinib and M351-0056 enhance the function of VISTA and ameliorate the development of SLE via IFN-I and noncanonical NF-κB pathway. Cell biology and toxicology. 2023 Dec;39(6):3287-3304. [Content Brief]
