239 Results for "

Neutralizing

" in MedChemExpress (MCE) Product Catalog:
Products (239)

239 Results for "Neutralizing" in MCE Product Catalog:

Tobevibart
Tobevibart
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Referencia número: HY-P990015
No. CAS: 2645440-65-7
Synonyms: VIR-3434

Target:  

HBV

Áreas de investigación:  

Infection

Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096) .
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Low molecular weight protamine
Low molecular weight protamine
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Referencia número: HY-P5107
No. CAS: 121052-30-0
Synonyms: LMWP; TDSP5
Target:  

VEGFR

Áreas de investigación:  

Cancer

Low molecular weight protamine (LMWP;TDSP5) is a truncated arginine-rich protamine peptide, as well as a heparin/low-molecular-weight heparin antidote and a cell-penetrating delivery carrier. Low molecular weight protamine neutralizes heparin-induced anticoagulant activities, including aPTT, anti-Xa and anti-IIa activities, and also neutralizes anti-Xa activity of commercially available low-molecular-weight heparin preparations. Low molecular weight protamine translocates across mammalian cell membranes, delivers conjugated impermeable molecules across tumor tissues, enhances skin permeability of conjugated epidermal growth factor, and accelerates wound healing when conjugated with epidermal growth factor. Low molecular weight protamine retains the in vitro cell proliferation activity of conjugated EGF, and also enables site-specific conjugation with peptides or proteins via genetic recombination. Low molecular weight protamine can be used in studies related to colon adenocarcinoma, skin wounds and diabetic skin wounds .
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STC314
STC314
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Referencia número: HY-145996
No. CAS: 401513-39-1
Target:  

Others

Áreas de investigación:  

Cardiovascular Disease Infection

STC314 is a histone-neutralizing agent. STC314 inhibits histone-mediated cytotoxicity, blocks histone-induced erythrocyte aggregation, reduces fragility, restores deformability and inhibits histone-induced aggregation and degranulation in human erythrocytes. STC314 reduces histone-mediated tissue damage, thrombocytopenia, anemia, and cell death, and improves survival in preclinical models. STC314 can be used for the research of sepsis, ischemia-reperfusion injury, and deep-vein thrombosis .
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HIV-1 inhibitor-77
HIV-1 inhibitor-77
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Referencia número: HY-169335
Target:  

HIV

Áreas de investigación:  

Infection

HIV-1 inhibitor-77 (compound 13) is a HIV-1 inhibitor. HIV-1 inhibitor-77 can neutralize all three tested viruses with the IC50 values of 0.14 μM, 8.28 μM and 2.92 μM for HIV-1CH58TF , HIV-1 JRFL and HIV-1 AD8, respectively .
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Anti-Mouse IL-25 Antibody (2C3)
Anti-Mouse IL-25 Antibody (2C3)
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Referencia número: HY-P990216

Target:  

Interleukin Related

Áreas de investigación:  

Inflammation/Immunology

Anti-Mouse IL-25 Antibody (2C3) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse IL-25. Anti-Mouse IL-25 Antibody (2C3) can neutralize IL-25. Anti-Mouse IL-25 Antibody (2C3) can be used for inflammation researches, such as colitis and asthma .
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MEDI-8852
MEDI-8852
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Referencia número: HY-P991446

Target:  

Influenza Virus

Áreas de investigación:  

Infection

MEDI-8852 is a human IgG1 monoclonal antibody against influenza A virus hemagglutinin (HA). MEDI-8852 binds to the conserved HA stalk epitope and neutralizes viral infectivity. MEDI-8852 reduces viral titers in mouse lung tissues. MEDI-8852 is applicable to research related to pandemic influenza . Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
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ADI-14448
ADI-14448
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Referencia número: HY-P992175

Target:  

RSV

Áreas de investigación:  

Infection

ADI-14448 is a RSV prefusion fusion glycoprotein inhibitor and HMPV fusion glycoprotein inhibitor, with a Kd of 3.8 × 10 -10 M for RSV preF. ADI-14448 binds to epitope III of RSV preF, thereby blocking viral infection. ADI-14448 neutralizes RSV subtype A and HMPV subtype A1. ADI-14448 can be used in studies related to respiratory syncytial virus infection and metapneumovirus infection .
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RO-5469754
RO-5469754
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Referencia número: HY-P992452

Target:  

Inhibitory Antibodies

Áreas de investigación:  

Inflammation/Immunology

RO-5469754 is a humanized monoclonal antibody that specifically binds to human thymic stromal lymphopoietin (TSLP). RO-5469754 blocks the binding of hTSLP to its receptor complex, thereby neutralizing TSLP-mediated biological activities, and does not cross-react with TSLP from cynomolgus monkeys or mice. RO-5469754 can be further used to generate the bispecific antibody TAVO101 × IL4R-dupi .
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Suvratoxumab
Suvratoxumab
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Referencia número: HY-P99583
No. CAS: 1629620-18-3
Synonyms: MEDI4893

Target:  

Bacterial

Áreas de investigación:  

Infection Inflammation/Immunology

Suvratoxumab (MEDI4893) is a long-acting, high-affinity human anti-α-toxin monoclonal antibody (IgG1κ type). Suvratoxumab potently neutralizes α-toxin, a key S. aureus virulence factor. Suvratoxumab improves survival and reduces lung injury in an immunocompromised mice model of pneumonia. Suvratoxumab also enhances the antibacterial activity of Vancomycin (HY-B0671) or Linezolid (HY-10394) .
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Oxazolone
Oxazolone
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Referencia número: HY-126360
No. CAS: 15646-46-5
Pureza:  ≥98.0%
Target:  

TNF Receptor Interleukin Related

Áreas de investigación:  

Inflammation/Immunology

Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins .
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Anti-Mouse CD73 Antibody (TY/23)
Anti-Mouse CD73 Antibody (TY/23)
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Referencia número: HY-P990263

Target:  

CD73

Áreas de investigación:  

Infection Inflammation/Immunology Cancer

Anti-Mouse CD73 Antibody (TY/23) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD73. Anti-Mouse CD73 Antibody (TY/23) can neutralize CD73. Anti-Mouse CD73 Antibody (TY/23) can be used for the researches of cancer, infection and immunology, such as B16F10 tumor and murine cytomegalovirus infection .
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Anti-Mouse CD18 Antibody (M18/2)
Anti-Mouse CD18 Antibody (M18/2)
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Referencia número: HY-P990288

Target:  

Integrin Transmembrane Glycoprotein

Áreas de investigación:  

Inflammation/Immunology

Anti-Mouse CD18 Antibody (M18/2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD18. Anti-Mouse CD18 Antibody (M18/2) can neutralize lymphocyte function-associated antigen 1 (LFA-1). Anti-Mouse CD18 Antibody (M18/2) can be used for the researches of immunology, such as heart transplantation .
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Anti-Mouse CD103 Antibody (M290)
Anti-Mouse CD103 Antibody (M290)
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Referencia número: HY-P990295

Target:  

Integrin

Áreas de investigación:  

Metabolic Disease Inflammation/Immunology Cancer

Anti-Mouse CD103 Antibody (M290) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD103. Anti-Mouse CD103 Antibody (M290) can neutralize CD103. Anti-Mouse CD103 Antibody (M290) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as B16.gp33 tumor, colitis and diabetes .
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Anti-Mouse IFN gamma Antibody (XMG1.2)
Anti-Mouse IFN gamma Antibody (XMG1.2)
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Referencia número: HY-P990798

Target:  

IFNAR

Áreas de investigación:  

Inflammation/Immunology Cancer

Anti-Mouse IFN gamma Antibody (XMG1.2) is a kind of rat-derived IgG1 antibody inhibitor, targeting to IFN-γ. Anti-Mouse IFN gamma Antibody (XMG1.2) can neutralize IFN-γ. Anti-Mouse IFN gamma Antibody (XMG1.2) can be used for the researches of cancer, inflammation and immunology, such as multiple myeloma and chronic inflammation .
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Golimumab
Golimumab
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Referencia número: HY-P99111
No. CAS: 476181-74-5
Synonyms: CNTO-148

Target:  

TNF Receptor Apoptosis Interleukin Related Caspase

Áreas de investigación:  

Inflammation/Immunology Cancer

Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research .
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Anti-IL6 Antibody (MH166)
Anti-IL6 Antibody (MH166)
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Referencia número: HY-P991601

Target:  

Interleukin Related

Áreas de investigación:  

Inflammation/Immunology

Anti-IL6 Antibody (MH166) is a murine anti-hIL-6 monoclonal antibody. Anti-IL6 Antibody (MH166) can completely neutralize the activity of hIL-6 in vitro, but when used in combination with hIL-6 in vivo, Anti-IL6 Antibody (MH166) can enhance the activity and prolong the half-life of hIL-6, and increase the production of antigen-specific antibodies .
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Anti-Mouse IL-15 Antibody (AIO.3)
Anti-Mouse IL-15 Antibody (AIO.3)
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Referencia número: HY-P990223

Target:  

Interleukin Related

Áreas de investigación:  

Infection Inflammation/Immunology Cancer

Anti-Mouse IL-15 Antibody (AIO.3) is a rat-derived IgG2a λ type antibody inhibitor, targeting to mouse IL-15. Anti-Mouse IL-15 Antibody (AIO.3) can neutralize IL-15. Anti-Mouse IL-15 Antibody (AIO.3) can be used for the researches of cancer, infection and inflammation, such as hepatitis virus infection and esophagitis .
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Anti-Mouse CD1d Antibody (19G11)
Anti-Mouse CD1d Antibody (19G11)
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Referencia número: HY-P990287

Target:  

CD1

Áreas de investigación:  

Inflammation/Immunology

Anti-Mouse CD1d Antibody (19G11) is a rat-derived IgG1 type antibody inhibitor, targeting to mouse CD1d. Anti-Mouse CD1d Antibody (19G11) can neutralize CD1d and inhibit the activation of invariant natural killer T (iNKT) cells. Anti-Mouse CD1d Antibody (19G11) can be used for the researches of inflammation and immunology, such as colitis .
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Visugromab (Powder)
Visugromab (Powder)
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Referencia número: HY-P99100A
No. CAS: 2556646-63-8
Synonyms: CLT-002 (Powder)

Target:  

TGF-beta/Smad PD-1/PD-L1 TGF-β Receptor

Áreas de investigación:  

Cancer

Visugromab (CTL-002) (Powder) is a GDF-15 neutralizing IgG4 mAb. Visugromab (Powder) has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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Aritinercept
Aritinercept
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Referencia número: HY-P992101
No. CAS: 3057276-00-0
Synonyms: AUR-200

Target:  

TNF Receptor IFNAR Interleukin Related

Áreas de investigación:  

Inflammation/Immunology

Aritinercept (AUR-200) is a recombinant fusion protein targeting TNFSF13B/BAFF/CD257. Aritinercept neutralizes BAFF and APRIL (TNFSF13), reduces B cell proliferation, suppresses peripheral B cells, lowers serum immunoglobulins. Aritinercept reduces renal damage markers, decreases IFNγ, IL-17A, and anti-dsDNA autoantibodies, and improves survival in a mouse model of SLE. ritinercept can be used for the research of systemic lupus erythematosus .
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