3 Results for "

(±)-Coriolic acid

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "(±)-Coriolic acid" in MCE Product Catalog:

Cat. No.: HY-113884A
CAS No.: 18104-45-5
Purity:  ≥99.0%
Synonyms: (±)-13-HODE
Target:  

Endogenous Metabolite

Research Areas:  

Inflammation/Immunology Cancer

(±)-Coriolic acid ((±)-13-HODE) is one of the two racemic monohydroxy fatty acids produced by non-enzymatic oxidation of linoleic acid. (±)-Coriolic acid induces TNF production in macrophages and upregulates Scavenger Receptor, thereby promoting the uptake of oxidized low-density lipoprotein. (±)-Coriolic acid induces the expression of cell adhesion molecules in endothelial cells. (±)-Coriolic acid can be used in research on psoriasis, atherosclerosis, and triple-negative breast cancer .
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Cat. No.: HY-113884B
CAS No.: 29623-28-7
Purity:  ≥99.0%
Synonyms: 13(S)-HODE
(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury .
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Cat. No.: HY-113884
CAS No.: 10219-69-9
Synonyms: 13(R)-HODE
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase. The presence of 13(R)-HODE in the supernatants and membranes of cultured bovine endothelial cells has been attributed to COX metabolism.1 13(R)-HODE is a weak (IC50=2.7 μM) inhibitor of U-46619-induced platelet aggregation.
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