18104-45-5
Chemical Structure
(±)-Coriolic acid
Synonym(s): (±)-13-HODE
- CAS No.: 18104-45-5
- Formula:C18H32O3
- Molecular Weight:296.44
IUPAC Name: (9Z,11E)-13-hydroxyoctadeca-9,11-dienoic acid
InChIKey: HNICUWMFWZBIFP-BSZOFBHHSA-N
SMILES: CCCCCC(O)/C=C/C=C\CCCCCCCC(O)=O
Biological Activity:
(±)-Coriolic acid ((±)-13-HODE) is one of the two racemic monohydroxy fatty acids produced by non-enzymatic oxidation of linoleic acid. (±)-Coriolic acid induces TNF production in macrophages and upregulates Scavenger Receptor, thereby promoting the uptake of oxidized low-density lipoprotein. (±)-Coriolic acid induces the expression of cell adhesion molecules in endothelial cells. (±)-Coriolic acid can be used in research on psoriasis, atherosclerosis, and triple-negative breast cancer[1][2][3][4][5].
The product specifications provided below refer solely to the active content of (±)-Coriolic acid.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(±)-Coriolic acid | 98.70% | (±)-Coriolic acid ((±)-13-HODE) is one of the two racemic monohydroxy fatty acids produced by non-enzymatic oxidation of linoleic acid. (±)-Coriolic acid induces TNF production in macrophages and upregulates Scavenger Receptor, thereby promoting the uptake of oxidized low-density lipoprotein. (±)-Coriolic acid induces the expression of cell adhesion molecules in endothelial cells. (±)-Coriolic acid can be used in research on psoriasis, atherosclerosis, and triple-negative breast cancer. The product specifications provided below refer solely to the active content of (±)-Coriolic acid. |
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-
Similarity Score 1.00
HY-1130779-Hydroxy-10(E),12(E)-octadecadienoic acid -
Similarity Score 1.00
HY-1134559(S)-HODE -
Similarity Score 1.00
HY-1135459(R)-HODE -
Similarity Score 1.00
HY-113545A(±)9-HODE -
Similarity Score 1.00
HY-113884(R)-Coriolic acid -
Similarity Score 1.00
HY-113884B(S)-Coriolic acid -
Similarity Score 1.00
HY-16576213-Hydroxy-9(E),11(E)-octadecadienoic acid -
Similarity Score 1.00
HY-W744666β-Dimorphecolic acid -
Similarity Score 0.95
HY-13031011(R)-HEDE -
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References
- [1]. Baer AN, et al. Free and esterified 13(R,S)-hydroxyoctadecadienoic acids: principal oxygenase products in psoriatic skin scales. Journal of lipid research. 1990 Jan;31(1):125-30.
- [2]. Friedrichs B, et al. 13-HPODE and 13-HODE modulate cytokine-induced expression of endothelial cell adhesion molecules differently. BioFactors (Oxford, England). 1999;9(1):61-72.
- [3]. Kwong SC, et al. Fatty acid binding protein 7 mediates linoleic acid-induced cell death in triple negative breast cancer cells by modulating 13-HODE. Biochimie. 2020 Dec;179:23-31.
- [4]. Khan-Merchant N, et al. Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice. The Journal of nutrition. 2002 Nov;132(11):3256-62. [Content Brief]
- [5]. Nishizuka Y, et al. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science (New York, N.Y.). 1992 Oct 23;258(5082):607-14. [Content Brief]
