Search Result
Results for "
(S,R,S)-AHPC-Me-C7 ester
" in MedChemExpress (MCE) Product Catalog:
| Cat. No. |
상품명 |
Target |
연구분야 |
Chemical Structure |
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- HY-125845A
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(S,S,S)-VH032-NH2 hydrochloride
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Ligands for E3 Ligase
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Cancer
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(S,S,S)-AHPC ((S,S,S)-VH032-NH2) hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC (Compound 27) is a ligand used as a negative control for (S,R,S)-AHPC (HY-125845). (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein .
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- HY-139218
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E3 Ligase Ligand-Linker Conjugates
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Others
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(S,R,S)-AHPC-Me-C6-NH2 is a VHL E3 ubiquitin ligase ligand-linker conjugate structurally modified based on VHL ligand 2 (HY-112078). (S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTACs .
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- HY-126456
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VH032-propargyl; VHL ligand 7
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Ligands for E3 Ligase
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Cancer
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(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs . (S,R,S)-AHPC-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-42419
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Ligands for E3 Ligase
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Cancer
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(S,R,S)-AHPC-Me-NHBoc is an E3 ubiquitin ligase VHL ligand used to recruit the VHL protein. (S,R,S)-AHPC-Me-NHBoc can be linked to a target protein ligand via a linker to form a PROTAC.
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-
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- HY-148671
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design PROTACs .
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- HY-147025
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PROTACs
TGF-beta/Smad
HIF/HIF Prolyl-Hydroxylase
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Inflammation/Immunology
Cancer
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(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual target PROTAC that can not only target to the ubiquitination and degradation of Smad3 but also improve the HIF-α protein level. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine has a multi-path anti-fibrosis function and a renal protection function for research of renal anemia. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine can be used for research on prostate cancer and other cancers .
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- HY-123109
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VH032-Boc
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Ligands for E3 Ligase
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Cancer
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(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology .
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- HY-141016
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PROTAC Linkers
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Cancer
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(S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-135045
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VH032-C4-COOH
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-C4-COOH (VH032-C4-COOH) (linker 45) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-targeted PROTAC .
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- HY-138550A
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based ligand and 3-unit PEG linker used in PROTAC technology .
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- HY-123109A
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(S,S,S)-VH032-Boc
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Ligands for E3 Ligase
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Cancer
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(S,S,S)-AHPC-Boc is the isomer of (S,R,S)-AHPC-Boc (HY-123109), and can be used as an experimental control. (S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology .
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- HY-138861A
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-C1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology .
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- HY-176366
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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AHPC-PEG6-CH2COOH is an E3 ligase ligand-linker conjugate that incorporates a VHL ligand and 6-unit PEG linker (HY-122702). AHPC-PEG6-CH2COOH can be used for synthesis of PROTAC CMP98 (HY-136257) .
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- HY-130849
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216 (HY-130604) .
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- HY-112078B
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Ligands for E3 Ligase
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Others
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(S,S,S)-AHPC-Me is an E3 ligase ligand. (S,S,S)-AHPC-Me can be used for synthesis of PROTAC (4S)-PROTAC SOS1 degrader-1 diTFA (HY-144657A) .
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- HY-W926049
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-C4-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-Me-C4-NH2 hydrochloride can be used to synthesize PROTAC.
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- HY-136163
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs .
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- HY-147192
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-O-PEG1-propargyl (Compound 10b) is an E3 ligand for the synthesis of PROTAC . (S,R,S)-AHPC-O-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-W190956
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Others
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Cancer
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(S,R,S)-AHPC-PEG4-acid is a synthetic PROTAC ligand that binds the E3 ligase ligand to the PEG4 arm, thereby enhancing PROTAC drug research and discovery .
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- HY-114176B
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VH032-C4-NH2 dihydrochloride
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-C4-NH2 dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC .
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- HY-138551A
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC ligand, it can be used in PROTAC technology .
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- HY-148896
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- HY-W998339
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Ligands for E3 Ligase
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Cancer
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(R,S,R)-AHPC-NHBoc is an E3 ubiquitin ligase VHL ligand used to recruit the VHL protein. (R,S,R)-AHPC-NHBoc can be linked to a target protein ligand via a linker to form a PROTAC.
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- HY-W1130361
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Ligands for E3 Ligase
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Cancer
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(S,R,S)-AHPC-PEG5-Azide is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-PEG5-Azide can be linked to a target protein ligand via a linker to form a PROTACs.
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- HY-W688682
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-C5-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-C5-NH2 hydrochloride can be used to synthesize PROTAC.
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- HY-W1130360
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Ligands for E3 Ligase
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Cancer
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(S,R,S)-AHPC-Me-PEG3-azide is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me-PEG3-azide can be linked to a target protein ligand via a linker to form a PROTACs.
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- HY-W998314
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-CO-C2-COOH is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-Me-CO-C2-COOH can be used to synthesize PROTAC.
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- HY-W998311
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-CO-C6-COOH is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-Me-CO-C6-COOH can be used to synthesize PROTAC.
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- HY-W998297
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-CO-C-PEG5-amine hydrochloride is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-CO-C-PEG5-amine hydrochloride can be used to synthesize PROTAC.
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- HY-W998315
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-CO-C3-COOH is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-Me-CO-C3-COOH can be used to synthesize PROTAC.
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- HY-136165
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology .
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- HY-132938
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- HY-W998298
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-C5-PEG3-C3 is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-C5-PEG3-C3 can be used to synthesize PROTAC.
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- HY-W998296
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-PEG6-C4-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-PEG6-C4-NH2 hydrochloride can be used to synthesize PROTAC.
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- HY-114176A
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VH032-C4-NH2
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC .
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- HY-W998246
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(R,R,S)-VH032-NH2; (R,R,S)-VHL ligand 1
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Ligands for E3 Ligase
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Cancer
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(R,R,S)-AHPC ((R,R,S)-VH032-NH2) is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein. (R,R,S)-AHPC can be linked to a target protein ligand via a linker to form a PROTACs.
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- HY-163953
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Ligands for E3 Ligase
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Cancer
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(S,R,S)-AHPC-Ala is a ligand for E3 ubiquitinase. (S,R,S)-AHPC-Ala can be used to synthesize PROTAC SMARCA2/4-degrader-23 (HY-163876) .
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- HY-163951
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Ligands for E3 Ligase
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Cancer
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(S,R,S)-AHPC-Ac is a ligand for E3 ubiquitinase. (S,R,S)-AHPC-Ac can be used to synthesize PROTAC SMARCA2/4-degrader-22 (HY-163875) .
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- HY-163934
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-phenylacetic acid is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-phenylacetic acid can be used to synthesize PROTAC SMARCA2/4-degrader-15 (HY-163868) .
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- HY-161194
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-acetyl-azetidine-PIP-boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-acetyl-azetidine-PIP-boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-161207
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-163936
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-p-toluic acid is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-p-toluic acid can be used to synthesize PROTAC SMARCA2/4-degrader-18 (HY-163871) .
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- HY-138862
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology .
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- HY-131959
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- HY-148406
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-C10-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC (HY-125845) based VHL ligand and a linker used for BET-Targeted PROTAC .
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- HY-172800
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-8-Sulfamoyloctanoic acid is an E3 ubiquitin ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-8-Sulfamoyloctanoic acid can be used for the synthesis of XZ338 (HY-172798) .
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- HY-112078A
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-
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- HY-125845B
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(S,S,S)-VH032-NH2
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Ligands for E3 Ligase
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Others
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(S,S,S)-AHPC ((S,S,S)-VH032-NH2) is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC (Compound 27) is a ligand used as a negative control for (S,R,S)-AHPC (HY-125845). (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein .
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- HY-141651
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-C3-COOH (compound 28i) is a carboxylic acid derivative of the VHL E3 ubiquitin ligase ligand-Linker conjugate. (S,R,S)-AHPC-C3-COOH can be used to synthesize PROTACs .
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- HY-163932
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Ligands for E3 Ligase
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Cancer
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(S,R,S)-AHPC-O-CF3 is a ligand for E3 ubiquitinase. (S,R,S)-AHPC-O-CF3 can be used to synthesize PROTAC SMARCA2/4-degrader-20 (HY-163873) .
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- HY-163933
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-CO-C-cyclohexane is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-CO-C-cyclohexane can be used to synthesize PROTAC SMARCA2/4-degrader-14 (HY-163867) .
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- HY-138861
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology .
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- HY-130798
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180) .
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- HY-159540
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- HY-177019
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E3 Ligase Ligand-Linker Conjugates
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Others
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(S,R,S)-AHPC-PEG3-ADIBO-adipic acid (Compound 2a) is a PROTAC ligand (Compound 1d)-linker conjugate. (S,R,S)-AHPC-PEG3-ADIBO-adipic acid can be coupled with aptamer to construct PROTAC .
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- HY-169372
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-CO-C4-bromine is an E3 Ligase Ligand-linker Conjugate for PROTAC synthesis. (S,R,S)-AHPC-CO-C4-bromine is composed of an E3 Ligase Ligand (HY-125845) and a linker
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- HY-163952
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Ac-CO-cyclohexene-Bpin is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-Ac-CO-cyclohexene-Bpin can be used to synthesize PROTAC SMARCA2/4-degrader-22 (HY-163875) .
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- HY-159780
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- HY-W800760
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S, R, S)-AHPC-PEG6-Tos is a combination of a von Hippel-Lindau (VHL)-recruiting ligand and PEGylated crosslinker with a tosyl group. The tosyl group is a good leaving group for nucleophilic substitution reactions. (S, R, S)-AHPC-PEG2-Tos is useful for synthesis of PROTAC compounds and molecules for targeted protein degradation.
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- HY-136186A
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VH032-C7-amine dihydrochloride
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-C7-amine dihydrochloride is the dihydrochloride form of (S,R,S)-AHPC-C7-amine (HY-136186). (S,R,S)-AHPC-C7-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker. (S,R,S)-AHPC-C7-amine can be used for estrogen-related receptor α (ERRα) PROTAC degrader .
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- HY-169970
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- HY-130642
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-C10-Br is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-C10-Br incorporates a VHL E3 ligase linker and MS432 based on the MEK1/2 inhibitor PD0325901 .
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- HY-163930
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- HY-163220
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-163231
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH can be used as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-163223
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-176804
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Ligands for E3 Ligase
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Cancer
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(R,S,R)-AHPC-Me-Ac is an E3 ligase ligand used in the synthesis of the PROTAC SHP2 Protein degrader-2 (HY-145703) .
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- HY-174875
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E3 Ligase Ligand-Linker Conjugates
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Others
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(S,R,S)-AHPC-CO-C2-phenylboronic acid is an E3 ligase ligand-linker conjugate that incorporates the VH032-based VHL ligand (HY-125845) and linker. (S,R,S)-AHPC-CO-C2-phenylboronic acid can be used for synthesis of PROTAC AF151 (HY-174873) .
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- HY-168019
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- HY-130847
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 (HY-130602) .
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- HY-130640
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- HY-159537
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- HY-163950
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-O-CF3-CO-cyclohexene-Bpin is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-O-CF3-CO-cyclohexene-Bpin can be used to synthesize PROTAC SMARCA2/4-degrader-20 (HY-163873) .
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- HY-172645
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-amide-C-O-C5-Br incorporates an VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-Me-amide-C-O-C5-Br can be used to design PROTACs, such as ERD-308 (HY-128600) .
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- HY-130711C
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VH032-C3-NH2 dihydrochloride
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-C3-NH2 (dihydrochloride) is the dihydrochloride form of (S,R,S)-AHPC-C3-NH2 (HY-130711). (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader .
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-
- HY-168290
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-12-((4-Bromobutyl)amino)dodecanamide incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-Me-12-((4-Bromobutyl)amino)dodecanamide can be used in the synthesis of PROTACs, such as MS934 (HY-153863). MS934 is a novel improved VHL-recruiting MEK 1/2 PROTAC degrader .
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- HY-173010
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E3 Ligase Ligand-Linker Conjugates
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Infection
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Me-(S,R,S)-AHPC-CO-C5-N3 is an E3 ligase ligand-linker conjugate composed of a VHL ligand (HY-112078) and a linker (HY-W123015). Me-(S,R,S)-AHPC-CO-C5-N3 can be used for synthesis of PROTACs, such as PROTAC CG167 (HY-173009) .
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- HY-158431
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- HY-W190942
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PROTAC Linkers
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Cancer
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(S, R, S)-AHPC-PEG8-acid is a synthetic PROTAC linker that incorporatess an E3 ligase ligand with a PEG8 linker to empower PROTAC drug R&D. PEG8 increases the compound's aqueous solubility. Acid group is reactive with amine containing molecule.
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- HY-174474
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- HY-168235
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- HY-W998245
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Ligands for E3 Ligase
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Cancer
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(R,R,R)-AHPC hydrochloride is an E3 ubiquitin ligase VHL ligand used to recruit the VHL protein. (R,R,R)-AHPC hydrochloride can be linked to a target protein ligand via a linker to form a PROTAC.
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- HY-W1130395
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Ligands for E3 Ligase
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Cancer
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(S,R,S)-AHPC-PEG2-SH is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-PEG2-SH can be linked to a target protein ligand via a linker to form a PROTACs.
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- HY-W590558
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-PEG8-NH2 is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-PEG8-NH2 can be used to synthesize PROTAC.
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- HY-W598206
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-PEG8-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-C5-NH2 hydrochloride can be used to synthesize PROTAC.
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- HY-W800964
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Ligands for E3 Ligase
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Cancer
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(S,R,S)-AHPC 2-OH hydrochloride is an E3 ubiquitin ligase VHL ligand used to recruit the VHL protein. (S,R,S)-AHPC 2-OH hydrochloride can be linked to a target protein ligand via a linker to form a PROTAC.
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- HY-163935
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-m-Tolylacetic acid is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-m-Tolylacetic acid can be used to synthesize PROTAC SMARCA2/4-degrader-17 (HY-163870) .
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- HY-179435
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VH032-NH-Bromooctanoic acid
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Bromooctanoic acid is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding linker (HY-W007700). (S,R,S)-AHPC-Bromooctanoic acid can serve as VHL (von Hippel-Lindau) ligand to recruit the VHL protein and serve as a key intermediate for the synthesis of complete PROTAC molecules .
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- HY-163954
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Ala-CO-cyclohexene-Bpin is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-Ala-CO-cyclohexene-Bpin can be used to synthesize PROTAC SMARCA2/4-degrader-23 (HY-163876) .
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- HY-185142
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Ligands for E3 Ligase
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Cancer
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The (S,R,S)-AHPC-Me-C8-NHS ester is an E3 ubiquitin ligase VHL ligand, used to recruit the VHL protein. The (S,R,S)-AHPC-Me-C8-NHS ester can be linked to the target protein ligand through a linker to form a PROTAC.
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- HY-W1130374
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Ligands for E3 Ligase
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Cancer
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(S,R,S)-AHPC-amide-C10-azide is an E3 ubiquitin ligase VHL ligand used to recruit the VHL protein. (S,R,S)-AHPC-amide-C10-azide can be linked to a target protein ligand via a linker to form a PROTAC.
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- HY-W937057
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-10-bromodecanoic acid is an E3 ligase ligand-linker conjugate that incorporates a VHL ligand 2 (HY-112078) and linker 10-bromoheptanoic acid. (S,R,S)-AHPC-Me-10-bromodecanoic acid can be used for synthesis of PROTAC PI3Kδ degrader-1 (HY-176239) .
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- HY-159594
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Dimethylformamide-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo is an E3 Ligase Ligand-Linker Conjugate. Dimethylformamide-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo can be used to synthesize PROTAC SMARCA2/4-degrader-2 (HY-159453) .
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- HY-163937
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-O-CF3 -CO-cyclohexane is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-O-CF3 -CO-cyclohexane can be used to synthesize PROTAC SMARCA2/4-degrader-20 (HY-163873) .
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- HY-161445
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH is a conjugate of the VHL ligand and linker of the E3 ubiquitinase VH032. The Linker of (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH can further be linked to target protein ligands (such as BCR-ABL1) to form PROTAC molecules .
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- HY-176530
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-amide-C4-Br incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-Me-amide-C4-Br can be used to design PROTAC, such as PROTAC ERK5 degrader-1 (HY-176528) .
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- HY-181905
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Infection
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(S,R,S)-AHPC-Me-C2-piperazine is an E3 ligase ligand-linker conjugate containing an E3 ligase ligand (HY-112078) and a PROTAC linker. (S,R,S)-AHPC-Me-C2-piperazine can be used in the PROTAC SARS-CoV-2 Mpro degrader-8 (HY-181870) .
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- HY-159593
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Ac-NH-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo is an E3 Ligase Ligand-Linker Conjugate. Ac-NH-(S,R,S)-AHPC-CO-cyclohexane-pyrimidine-diazabicyclo can be used to synthesize PROTAC SMARCA2/4-degrader-1 (HY-159452) .
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- HY-181356
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E3 Ligase Ligand-Linker Conjugates
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Others
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(S,R,S,R)-AHPC-Me-CO-C7-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S,R)-AHPC-Me based VHL ligand and a linker used in PROTAC technology. (S,R,S,R)-AHPC-Me-CO-C7-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-28 (HY-181355) .
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- HY-403301
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| Cat. No. |
상품명 |
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Classification |
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- HY-126456
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VH032-propargyl; VHL ligand 7
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PROTAC Synthesis
Alkynes
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(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs . (S,R,S)-AHPC-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-147192
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Alkynes
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(S,R,S)-AHPC-O-PEG1-propargyl (Compound 10b) is an E3 ligand for the synthesis of PROTAC . (S,R,S)-AHPC-O-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-W1130361
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Azide
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(S,R,S)-AHPC-PEG5-Azide is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-PEG5-Azide can be linked to a target protein ligand via a linker to form a PROTACs.
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-
- HY-181356
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Azide
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(S,R,S,R)-AHPC-Me-CO-C7-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S,R)-AHPC-Me based VHL ligand and a linker used in PROTAC technology. (S,R,S,R)-AHPC-Me-CO-C7-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-28 (HY-181355) .
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