5 Results for "

ABCC3

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "ABCC3" in MCE Product Catalog:

77
77 Publications Verification
Cat. No.: HY-N0488A
CAS No.: 57-22-7
Synonyms: Leurocristine; NSC-67574; 22-Oxovincaleukoblastine
Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas [3] .
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1
1 Cited Publications
Cat. No.: HY-N2382
CAS No.: 81917-50-2
Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of CYP1A2 (IC50 = 6.44 μM, competitive), CYP2D6 (IC50 = 13.88 μM, competitive) and CYP3A4 (IC50 = 4.52 μM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and ABCC3. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel .
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Cat. No.: HY-RS00062
Research Areas:  

Others

ABCC3 Human Pre-designed siRNA Set A contains three designed siRNAs for ABCC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS26480
Research Areas:  

Others

Abcc3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Abcc3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS19977
Research Areas:  

Others

Abcc3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Abcc3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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