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ABCC3

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By Targets:	Apoptosis (1) Cytochrome P450 (1) Microtubule/Tubulin (1) Mitosis (1) P-glycoprotein (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (2) Infection (1) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0488A

Vincristine 70+ Cited Publications Leurocristine; NSC-67574; 22-Oxovincaleukoblastine	Apoptosis Microtubule/Tubulin Mitosis	Infection Cancer
Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas ^[3] .

HY-N2382

Polyphyllin H 1 Publications Verification	Cytochrome P450 P-glycoprotein	Metabolic Disease Cancer
Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of CYP1A2 (IC₅₀ = 6.44 μM, competitive), CYP2D6 (IC₅₀ = 13.88 μM, competitive) and *CYP3A4* (IC₅₀ = 4.52 μM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and *ABCC3*. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel .

HY-RS00062

ABCC3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ABCC3 Human Pre-designed siRNA Set A contains three designed siRNAs for ABCC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ABCC3 Human Pre-designed siRNA Set A ABCC3 Human Pre-designed siRNA Set A

HY-RS26480

Abcc3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Abcc3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Abcc3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Abcc3 Rat Pre-designed siRNA Set A Abcc3 Rat Pre-designed siRNA Set A

HY-RS19977

Abcc3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Abcc3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Abcc3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Abcc3 Mouse Pre-designed siRNA Set A Abcc3 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0488A

Vincristine 70+ Cited Publications Leurocristine; NSC-67574; 22-Oxovincaleukoblastine	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Source Classification Cancer	Apoptosis Microtubule/Tubulin Mitosis
Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas ^[3] .

HY-N2382

Polyphyllin H 1 Publications Verification	Structural Classification other families Plants Steroids Source Classification	Cytochrome P450 P-glycoprotein
Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of CYP1A2 (IC₅₀ = 6.44 μM, competitive), CYP2D6 (IC₅₀ = 13.88 μM, competitive) and *CYP3A4* (IC₅₀ = 4.52 μM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and *ABCC3*. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel .

ABCC3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ABCC3 Human Pre-designed siRNA Set A contains three designed siRNAs for ABCC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Abcc3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Abcc3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Abcc3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Abcc3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Abcc3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Abcc3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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ABCC3

Inhibitors & Agonists

NaturalProducts

Oligonucleotides

Natural
Products