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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
48 Results for "
ACVR1
" in MedChemExpress (MCE) Product Catalog:
Products (48)
48 Results for "ACVR1" in MCE Product Catalog:
1
1 Cited Publications
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ALK2-IN-2 is an orally active and selective inhibitor of ALK2 (ACVR1), with an IC50 value of 9 nM, and over 700-fold selectivity against ALK3. ALK2-IN-2 can inhibit oxidative stress and protect endothelial cells [1] .
Synonyms: TP-0184
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Itacnosertib (TP-0184) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM). Itacnosertib exhibits anti-leukemic activity [1] .
Cat. No.: HY-P990022
CAS No.: 2566473-71-8
Synonyms: DS-6016A
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Synonyms: TP-0184 hydrochloride
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Itacnosertib hydrochloride (TP-0184 hydrochloride) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM). Itacnosertib hydrochloride exhibits anti-leukemic activity [1] .
Cat. No.: HY-RS00236
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ACVR1 Human Pre-designed siRNA Set A contains three designed siRNAs for ACVR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00237
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Acvr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00238
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Acvr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Acvr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00242
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ACVR1C Human Pre-designed siRNA Set A contains three designed siRNAs for ACVR1C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W064657
CAS No.: 1380317-28-1
Momelotinib (dihydrochloride) is a JAK1/JAK2 inhibitor that also antagonizes ACVR1, leading to downregulation of Hepcidin expression and increased availability of iron for erythropoiesis. Momelotinib (dihydrochloride) can reduce transfusion burden and spleen enlargement caused by myelofibrosis, showing potential value in research and application within the field of myelofibrosis [1].
Cat. No.: HY-174784
Human ACVR1C mRNA encodes the human activin A receptor type 1C (ACVR1C) protein, a type I receptor for the TGFB family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.
Cat. No.: HY-RS00239
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ACVR1B Human Pre-designed siRNA Set A contains three designed siRNAs for ACVR1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00240
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Acvr1b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr1b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00241
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Acvr1b Rat Pre-designed siRNA Set A contains three designed siRNAs for Acvr1b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00243
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Acvr1c Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr1c gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00244
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Acvr1c Rat Pre-designed siRNA Set A contains three designed siRNAs for Acvr1c gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-109179AR
CAS No.: 2409543-84-4
Synonyms: TP-0184 hydrochloride (Standard)
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JAK Reference Standards Anaplastic lymphoma kinase (ALK) FLT3 STAT PI3K Akt mTOR TGF-beta/Smad TGF-β Receptor
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Itacnosertib hydrochloride (Standard) is the analytical standard of Itacnosertib (hydrochloride) (HY-109179A). This product is intended for research and analytical applications. Itacnosertib hydrochloride (TP-0184 hydrochloride) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM). Itacnosertib hydrochloride exhibits anti-leukemic activity [1] .
Cat. No.: HY-109179R
CAS No.: 1628870-27-8
Synonyms: TP-0184 (Standard)
Target:
Reference Standards JAK Anaplastic lymphoma kinase (ALK) FLT3 STAT PI3K Akt mTOR TGF-beta/Smad TGF-β Receptor
Research Areas:
Itacnosertib (Standard) is the analytical standard of Itacnosertib (HY-109179). This product is intended for research and analytical applications. Itacnosertib (TP-0184) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM). Itacnosertib exhibits anti-leukemic activity [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
