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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
56 Results for "
ACVR1
" in MedChemExpress (MCE) Product Catalog:
Products (56)
56 Results for "ACVR1" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: TP-0184
Áreas de investigación:
Itacnosertib (TP-0184) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM). Itacnosertib exhibits anti-leukemic activity [1] .
1
1 Cited Publications
Target:
Áreas de investigación:
ALK2-IN-2 is an orally active and selective inhibitor of ALK2 (ACVR1), with an IC50 value of 9 nM, and over 700-fold selectivity against ALK3. ALK2-IN-2 can inhibit oxidative stress and protect endothelial cells [1] .
1
1 Cited Publications
Synonyms: TP-0184 hydrochloride
Áreas de investigación:
Itacnosertib hydrochloride (TP-0184 hydrochloride) is the inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM) and JAK2 (IC50=8540 nM). Itacnosertib hydrochloride exhibits anti-leukemic activity [1] .
Referencia número: HY-P990022
No. CAS: 2566473-71-8
Synonyms: DS-6016A
Target:
Áreas de investigación:
Referencia número: HY-RS00236
Target:
Áreas de investigación:
ACVR1 Human Pre-designed siRNA Set A contains three designed siRNAs for ACVR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS00237
Target:
Áreas de investigación:
Acvr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS00238
Target:
Áreas de investigación:
Acvr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Acvr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS00242
Target:
Áreas de investigación:
ACVR1C Human Pre-designed siRNA Set A contains three designed siRNAs for ACVR1C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-W064657
No. CAS: 1380317-28-1
Momelotinib (dihydrochloride) is a JAK1/JAK2 inhibitor that also antagonizes ACVR1, leading to downregulation of Hepcidin expression and increased availability of iron for erythropoiesis. Momelotinib (dihydrochloride) can reduce transfusion burden and spleen enlargement caused by myelofibrosis, showing potential value in research and application within the field of myelofibrosis [1].
Referencia número: HY-RS00239
Target:
Áreas de investigación:
ACVR1B Human Pre-designed siRNA Set A contains three designed siRNAs for ACVR1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS00240
Target:
Áreas de investigación:
Acvr1b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr1b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS00241
Target:
Áreas de investigación:
Acvr1b Rat Pre-designed siRNA Set A contains three designed siRNAs for Acvr1b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS00243
Target:
Áreas de investigación:
Acvr1c Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr1c gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS00244
Target:
Áreas de investigación:
Acvr1c Rat Pre-designed siRNA Set A contains three designed siRNAs for Acvr1c gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-174784
Human ACVR1C mRNA encodes the human activin A receptor type 1C (ACVR1C) protein, a type I receptor for the TGFB family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.
Referencia número: HY-P705731
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1; Activin A Receptor, Type II-Like Kinase 2; Prev. ACVRLK2; Receptor Protein Serine/Threonine Kinase; SKR1; Hydroxyalkyl-Protein Kinase; TGF-B Superfamily Receptor Type I; Alternative Protein ACVR1; Activin Receptor Type-1; ACTR-I; Activin Receptor T
Species:
Human
Source:
sf9 insect cells
Referencia número: HY-P705993
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1; Activin A Receptor, Type II-Like Kinase 2; Prev. ACVRLK2; Receptor Protein Serine/Threonine Kinase; SKR1; Hydroxyalkyl-Protein Kinase; TGF-B Superfamily Receptor Type I; Alternative Protein ACVR1; Activin Receptor Type-1; ACTR-I; Activin Receptor T
Species:
Human
Source:
sf9 insect cells
Referencia número: HY-P705732
Pureza: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ACVR1; Activin A Receptor, Type II-Like Kinase 2; Prev. ACVRLK2; Receptor Protein Serine/Threonine Kinase; SKR1; Hydroxyalkyl-Protein Kinase; TGF-B Superfamily Receptor Type I; Alternative Protein ACVR1; Activin Receptor Type-1; ACTR-I; Activin Receptor T
Species:
Human
Source:
sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
