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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
46 Results for "
AKR1A1
" in MedChemExpress (MCE) Product Catalog:
Products (46)
46 Results for "AKR1A1" in MCE Product Catalog:
17
2
2
2 Cited Publications
Research Areas:
S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells .
2
2 Cited Publications
Cat. No.: HY-D1341
CAS No.: 878019-47-7
Research Areas:
Coumberone is a metabolic fluorogenic probe, and isoform-selective substrate for all AKR1C isoforms. Coumberone can be reduced by all four members of the AKR1C family to its fluorescent alcohol coumberol. Coumberone can be used for the research of AKR1C .
1
1 Cited Publications
Synonyms: Glucogallin; 1-O-Galloyl-β-D-glucose
1
Target:
Research Areas:
Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol .
1
1 Cited Publications
Cat. No.: HY-N0310
CAS No.: 51330-27-9
Cat. No.: HY-N0412
CAS No.: 117479-87-5
Category:
Iridoids Labiatae Terpenoids Phaseolus lunatus L. Plants Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-N2282
CAS No.: 91653-50-8
Synonyms: Zingiberensis newsaponin
Cat. No.: HY-RS00531
Target:
Research Areas:
AKR1A1 Human Pre-designed siRNA Set A contains three designed siRNAs for AKR1A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24390
Target:
Research Areas:
Akr1a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Akr1a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17235
Target:
Research Areas:
Akr1b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Akr1b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17921
Target:
Research Areas:
Akr1a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Akr1a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Research Areas:
5-Bromo-3-phenyl salicylic acid is a selective inhibitor for human 20α-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 140 nM .
Cat. No.: HY-N8549A
CAS No.: 28423-48-5
Category:
Cardiacglycosides Metabolic Disease Endogenous metabolite Disease Research Fields Steroids
Target:
Cat. No.: HY-177415
CAS No.: 2353515-08-7
Target:
Research Areas:
JSD26 is a selective and orally active SCoR2 (AKR1A1) inhibitor with an IC50 of 93 nM. JSD26 has 10-fold selectivity for SCoR2 versus AKR1B1. JSD26 can be used for the study acute kidney injury (AKI) .
Cat. No.: HY-156701
CAS No.: 1428988-21-9
Research Areas:
BAY-1128688 is a potent, orally active and selective AKR1C3 inhibitor with IC50 < 2 nM. BAY-1128688 shows high selectivity over related AKR1C enzymes (1C1, 1C2, 1C4) and AKR1D1. BAY-1128688 exhibits no relevant activity at major nuclear hormone receptors. BAY-1128688 reduces endometriotic lesions in the marmoset monkey endometriosis model. BAY-1128688 can be used for endometriosis research .
Cat. No.: HY-RS00532
Target:
Research Areas:
AKR1B1 Human Pre-designed siRNA Set A contains three designed siRNAs for AKR1B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-175331
CAS No.: 59935-47-6
Target:
Research Areas:
ALR2-IN-7 (Compound 5a) is a highly potent and selective aldose reductase (ALR2/AKR1B1) inhibitor (Ki=8.71 nM). ALR2-IN-7 is promising for research of diabetic complications (e.g., retinopathy, nephropathy) and cancers .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
