53-05-4
53-05-4
Chemical Structure
Tetrahydrocortisone
- CAS No.: 53-05-4
- Formula:C21H32O5
- Molecular Weight:364.48
IUPAC Name: (3R,5R,8S,9S,10S,13S,14S,17R)-3,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethylhexadecahydro-11H-cyclopenta[a]phenanthren-11-one
InChIKey: SYGWGHVTLUBCEM-ZIZPXRJBSA-N
SMILES: C[C@@]1([C@]([H])([C@]2([C@]([H])3[C@]4(C)[C@]([H])(CC2)C[C@@H](CC4)O)[H])CC[C@@]1(C(CO)=O)O)CC3=O
Biological Activity: Tetrahydrocortisone is a corticosteroid catalyzed from endogenous glucocorticoids by AKR1D1 (5β-reductase). Its formation is mediated by AKR1D1 and regulated by the glucocorticoid receptor (GR). As one of the final products of glucocorticoid inactivation metabolism, Tetrahydrocortisone participates in the maintenance of glucocorticoid metabolic homeostasis in vivo. Tetrahydrocortisone can be used for mechanistic studies of metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes, and also serves as a biomarker for in vivo AKR1D1 activity and glucocorticoid metabolic status[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tetrahydrocortisone | 99.97% | Tetrahydrocortisone is a corticosteroid catalyzed from endogenous glucocorticoids by AKR1D1 (5β-reductase). Its formation is mediated by AKR1D1 and regulated by the glucocorticoid receptor (GR). As one of the final products of glucocorticoid inactivation metabolism, Tetrahydrocortisone participates in the maintenance of glucocorticoid metabolic homeostasis in vivo. Tetrahydrocortisone can be used for mechanistic studies of metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes, and also serves as a biomarker for in vivo AKR1D1 activity and glucocorticoid metabolic status. | ||||||||||||||||||||
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Tetrahydrocortisone (Standard) | ≥98% | Tetrahydrocortisone (Standard) is the analytical standard of Tetrahydrocortisone. This product is intended for research and analytical applications. Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase. | ||||||||||||||||||||
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Tetrahydrocortisone-d5 | Tetrahydrocortisone-d5 is the deuterium labeled Tetrahydrocortisone. Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase. | |||||||||||||||||||||
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Tetrahydrocortisone-d6 | Tetrahydrocortisone-d6 is the deuterium labeled Tetrahydrocortisone. Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase. | |||||||||||||||||||||
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Tetrahydrocortisone-d5-1 | Tetrahydrocortisone-d5-1 is the deuterium labeled Tetrahydrocortisone (HY-113114). Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase. | |||||||||||||||||||||
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Allotetrahydrocortisol | 99.9% | Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human. It is produced in adrenal cortex and plays a crucial role in many physiological processes. | ||||||||||||||||||||
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Tetrahydro-11-deoxycortisol | 98.20% | Tetrahydro-11-deoxycortisol (Tetrahydrodeoxycortisol) is an endogenous metabolite present in Urine that can be used for the research of 11 Beta Hydroxylase Deficiency. | ||||||||||||||||||||
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Alphadolone | 98.71% | Alphadolone (Alfadolone) is a GABAA positive allosteric modulator with antinociceptive activity. Alphadolone produces GABAA-mediated antinociception and analgesia, and can induce anesthesia, loss of righting reflex, and deep sedation. Alphadolone blocks calcium channels and downstream cascades of calcium influx, and inhibits histamine release from mast cells. Alphadolone enhances the antinociceptive effects of opioids. Alphadolone promotes Candida albicans yeast/hyphal growth, increases lipid and oxygen uptake, alters sterol composition, and enhances tolerance to polyene antifungals. Alphadolone can be used in pain-related research. | ||||||||||||||||||||
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Tetrahydrocortisol | 99.91% | Tetrahydrocortisol is a metabolite of Hydrocortisone (HY-N0583) that fails to activate glucocorticoid receptor. Tetrahydrocortisol inhibits Dexamethasone (HY-14648)-induced formation of cross-linked actin networks. Tetrahydrocortisol acts as a synergist to enhance the activity of anticancer agents. Tetrahydrocortisol can be used in the research of primary open-angle glaucoma, ocular hypertension, lung cancer and breast cancer. | ||||||||||||||||||||
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Tetrahydrocortisone acetate | Tetrahydrocortisone acetate is a intermediate product for production of tetrahydrocortisone 3-glucuronide. | |||||||||||||||||||||
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5-Dihydrocortisone | 99.83% | 5-Dihydrocortisone is a 5-Dihydrocortisone with mixture of isomers. 5β-Dihydrocortisone is a sterol metabolite of cortisone by 5β-reductase (AKR1D1) in liver | ||||||||||||||||||||
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Cortolone | Cortolone (α-Cortolone) is a metabolite of the glucocorticoid cortisol (Hydrocortisone (HY-N0583)). Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex. | |||||||||||||||||||||
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Tetrahydro-11-dehydrocorticosterone | 99.79% | Tetrahydro-11-dehydrocorticosterone is a 11β-HSD inhibitor. | ||||||||||||||||||||
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5α-Dihydrocortisol | 98.17% | 5α-Dihydrocortisol (5α-DHF), a metabolite of Hydrocortisone (Cortisol) (HY-N0583), is a steroid hormone. 5α-Dihydrocortisol can enhance the mineralocorticoid activity of aldosterone. | ||||||||||||||||||||
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b-Cortolone | b-Cortolone is the metabolite of Cortisol (HY-N0583), that reveals relatively low biological activity. | |||||||||||||||||||||
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