119 Results for "

AS1-6

" in MedChemExpress (MCE) Product Catalog:
Products (119)

119 Results for "AS1-6" in MCE Product Catalog:

1
Spermidine-13C4 hydrochloride
Spermidine-13C4 hydrochloride
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1 Cited Publications
Cat. No.: HY-B1776AS1
CAS No.: 1313734-84-7
Spermidine- 13C4 (hydrochloride) is the 13C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .
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α-Hydroxyglutaric acid-d4 disodium
α-Hydroxyglutaric acid-d4 disodium
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Cat. No.: HY-113038AS1
CAS No.: 2483831-91-8
Purity:  95.9%
Synonyms: 2-Hydroxyglutarate-d4 disodium; 2-Hydroxyglutaric acid-d4 disodium; 2-Hydroxypentanedioic acid-d4 disodium
α-Hydroxyglutaric acid-d4 (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium . α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases .
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Clomiphene-d5 citrate
Clomiphene-d5 citrate
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Cat. No.: HY-118861AS1
CAS No.: 1217200-17-3
Synonyms: Clomifene-d5 citrate; (Z/E)-Enclomiphene-d5 citrate; (Z/E)-Enclomifene-d5 citrate
Clomiphene-d5 (citrate) is the deuterium labeled Enclomiphene citrate. Enclomiphene citrate is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property .
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Doxorubicin-13C,d3 TFA
Doxorubicin-13C,d3 TFA
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Cat. No.: HY-15142AS1
Synonyms: Hydroxydaunorubicin-13C,d3 TFA
Doxorubicin- 13C,d3 TFA is the deuterium and 13C labeled Doxorubicin. Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibits topoisomerase II with an IC50 of 2.67 μM, thus stoppin
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Rosuvastatin-d6
Rosuvastatin-d6
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Cat. No.: HY-17504AS1
CAS No.: 2070009-40-2
Synonyms: ZD 4522-d6
Rosuvastatin-d6 (ZD 4522-d6) is deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks hERG current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .
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Barnidipine-d5
Barnidipine-d5
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Cat. No.: HY-107322AS1
CAS No.: 2771469-19-1
Purity:  98.97%
Synonyms: Mepirodipine-d5; YM-09730-5-d5 Free bASe
Barnidipine-d5 is the deuterium-labeled Barnidipine (HY-107322A). Barnidipine-d5 (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [ 3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors . Barnidipine-d5 (Mepirodipine) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action .
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Galactose 1-phosphate-13C-1 potassium
Galactose 1-phosphate-13C-1 potassium
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Cat. No.: HY-113143AS1
CAS No.: 478518-80-8
Purity:  99.16%
Galactose 1-phosphate- 13C-1 potassium is the 13C-labeled Galactose 1-phosphate Potassium salt (HY-113143A). Galactose 1-phosphate Potassium salt acts as a competitive substrate inhibitor of galactose-1-phosphate uridylyltransferase (GALT). Galactose 1-phosphate Potassium salt is a competitive inhibitor of Phosphoglucomutase, yet the rate at which this enzyme converts Galactose 1-phosphate to Galactose-6-phosphate is 400 times slower than the rate of converting Glucose-1-phosphate. Galactose 1-phosphate Potassium salt can be used in studies related to Saccharomyces cerevisiae infection and type I galactosemia .
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Sunitinib-d4
Sunitinib-d4
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Cat. No.: HY-10255AS1
CAS No.: 1126721-79-6
Sunitinib-d4 is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation .
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Valproic acid-d14 sodium
Valproic acid-d14 sodium
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Cat. No.: HY-10585AS1
Purity:  96.45%
Synonyms: Sodium Valproate-d14; VPA-d14 sodium; 2-Propylpentanoic acid-d14 sodium
Valproic acid-d14 (sodium) is deuterium labeled Valproic acid (sodium). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
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Orexin A-13C18,15N3 (human, rat, mouse) TFA
Orexin A-13C18,15N3 (human, rat, mouse) TFA
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Cat. No.: HY-106224AS1
Synonyms: Hypocretin-1-13C18,15N3 (human, rat, mouse) TFA
Target:  

Isotope-Labeled Compounds Orexin Receptor (OX Receptor)

Research Areas:  

Neurological Disease

Orexin A- 13C18, 15N3 (human, rat, mouse) ((Hypocretin-1- 13C18, 15N3 (human, rat, mouse)) TFA is the 13C- and 15N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .
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Taurolithocholic Acid-d5 sodium salt
Taurolithocholic Acid-d5 sodium salt
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Cat. No.: HY-113308AS1
CAS No.: 1265476-97-8
Taurolithocholic Acid-d5 (sodium) is the deuterium labeled Taurolithocholic acid sodium salt. Taurolithocholic Acid sodium salt is an orally active bile acid and antiviral agent. Taurolithocholic Acid sodium salt upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic Acid sodium salt also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic Acid sodium salt serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic Acid sodium salt shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic Acid sodium salt not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis .
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Escitalopram-d4 oxalate
Escitalopram-d4 oxalate
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Cat. No.: HY-14258AS1
Synonyms: (S)-Citalopram-d4 oxalate; (S)-(+)-Citalopram-d4 oxalate
Escitalopram-d4 (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .
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Exatecan-d3 mesylate
Exatecan-d3 mesylate
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Cat. No.: HY-13631AS1
Synonyms: DX8951f-d3 mesylate
Exatecan-d3 (DX8951f-d3) mesylate is deuterium-labeled Exatecan mesylate (HY-13631A). Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL .
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Valacyclovir-d4 hydrochloride
Valacyclovir-d4 hydrochloride
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Cat. No.: HY-17425AS1
CAS No.: 1331910-75-8
Valacyclovir-d4 (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) .
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Dopamine-13C6 hydrochloride
Dopamine-13C6 hydrochloride
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Cat. No.: HY-B0451AS1
CAS No.: 335080-94-9
Synonyms: ASL279-13C6
Dopamine- 13C6 (hydrochloride) is the 13C labeled Dopamine hydrochloride (ASL279) .
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Varenicline-d4 hydrochloride
Varenicline-d4 hydrochloride
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Cat. No.: HY-10019AS1
Varenicline-d4 hydrochloride is a deuterium labeled Varenicline (dihydrochloride) (HY-10019A) . Varenicline (CP 526555) dihydrochloride is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline dihydrochloride is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively . Varenicline dihydrochloride is a nicotinic ligand based on the structure of cytosine, and has the potential for smoking cessation treatment .
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(Rac)-Atomoxetine-d5 hydrochloride
(Rac)-Atomoxetine-d5 hydrochloride
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Cat. No.: HY-107370AS1
CAS No.: 1398065-95-6
Purity:  ≥99.0%
Synonyms: (Rac)-Tomoxetine-d5 hydrochloride; (Rac)-LY 139603-d5
(Rac)-Atomoxetine-d5 (hydrochloride) is the deuterium labeled (Rac)-Atomoxetine hydrochloride .
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Taurohyodeoxycholic acid-d4 sodium
Taurohyodeoxycholic acid-d4 sodium
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Cat. No.: HY-114360AS1
Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium) . Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.
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Difloxacin-d3 hydrochloride
Difloxacin-d3 hydrochloride
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Cat. No.: HY-121272AS1
CAS No.: 1173021-89-0
Purity:  ≥99.0%
Synonyms: A-56619-d3 hydrochloride
Difloxacin-d3 (hydrochloride) is the deuterium labeled Difloxacin (hydrochloride) .
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Beclometasone dipropionate-d10
Beclometasone dipropionate-d10
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Cat. No.: HY-13571AS1
Beclometasone dipropionate-d10 is the deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release .
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