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Results for "

Acetyl CoA-Carboxylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (52) ADC Payload (3) AMPK (6) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (4) Apoptosis (4) ATP Citrate Lyase (1) Autophagy (3) Bacterial (6) Cytochrome P450 (1) Drug Derivative (2) Drug Intermediate (1) Drug Metabolite (1) Endogenous Metabolite (2) Environmental Pollutants (2) Fluorescent Dye (3) Free Fatty Acid Receptor (1) FXR (2) HBV (3) Herbicide (3) HIV (3) HMG-CoA Reductase (HMGCR) (1) Insecticide (2) Isotope-Labeled Compounds (1) Lipoxygenase (1) Mitochondrial Metabolism (1) Mitophagy (3) Nucleoside Antimetabolite/Analog (1) Parasite (2) PROTACs (1) Pyruvate Carboxylase (PC) (1) Reference Standards (11) Topoisomerase (3)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Infection (14) Inflammation/Immunology (6) Metabolic Disease (18) Neurological Disease (2)

By Targets:

Acetyl-CoA Carboxylase (52)

ADC Payload (3)

AMPK (6)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (4)

Apoptosis (4)

ATP Citrate Lyase (1)

Autophagy (3)

Bacterial (6)

Cytochrome P450 (1)

Drug Derivative (2)

Drug Intermediate (1)

Drug Metabolite (1)

Endogenous Metabolite (2)

Environmental Pollutants (2)

Fluorescent Dye (3)

Free Fatty Acid Receptor (1)

FXR (2)

HBV (3)

Herbicide (3)

HIV (3)

HMG-CoA Reductase (HMGCR) (1)

Insecticide (2)

Isotope-Labeled Compounds (1)

Lipoxygenase (1)

Mitochondrial Metabolism (1)

Mitophagy (3)

Nucleoside Antimetabolite/Analog (1)

Parasite (2)

PROTACs (1)

Pyruvate Carboxylase (PC) (1)

Reference Standards (11)

Topoisomerase (3)

By Research Areas:

Cancer (9)

Cardiovascular Disease (2)

Infection (14)

Inflammation/Immunology (6)

Metabolic Disease (18)

Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Acetyl-CoA Carboxylase Acetyl-CoA synthetase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 650 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye	Infection Cancer
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-101068

TOFA 10+ Cited Publications RMI14514; MDL14514	Acetyl-CoA Carboxylase	Cancer
TOFA (RMI14514;MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA ).

HY-16901

Firsocostat 20+ Cited Publications ND-630; GS-0976; NDI-010976	Acetyl-CoA Carboxylase	Metabolic Disease
Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC₅₀ values of 2.1 and 6.1 nM, respectively.

HY-112083

BAY-3827 10+ Cited Publications	AMPK	Cancer
BAY-3827, a chemical probe, is a potent and selective AMPK inhibitor with IC₅₀ values of 1.4 nM at low (10 μM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines .

HY-15142R

Doxorubicin hydrochloride (Standard) 5 Publications Verification Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard)	Reference Standards Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye	Infection Cancer
Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-101842

ND-646 10+ Cited Publications	Acetyl-CoA Carboxylase	Cancer
ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC₅₀s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.

HY-15142A

Doxorubicin Hydroxydaunorubicin	ADC Payload Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV Fluorescent Dye	Infection Cancer
Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy .

HY-15259

CP-640186 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 is an orally active and cell-permeable **Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀*s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase* (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation .

HY-12942

PF-05175157 3 Publications Verification	Acetyl-CoA Carboxylase	Metabolic Disease
PF-05175157 is broad spectrum **acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀**s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.

HY-N0468

Rebaudioside D 1 Publications Verification	FXR Acetyl-CoA Carboxylase	Metabolic Disease
Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates **Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase**. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research .

HY-152117

Acetyl-CoA Carboxylase-IN-1	Acetyl-CoA Carboxylase Bacterial	Infection
Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC₅₀ value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity .

HY-P1123

MEDICA16	ATP Citrate Lyase Free Fatty Acid Receptor Acetyl-CoA Carboxylase	Metabolic Disease
MEDICA16 is an orally active **acetyl-CoA carboxylase and ATP-citrate lyase** inhibitor. MEDICA16 limits the acetyl-CoA supply for acetyl-CoA carboxylase, inhibits acetyl-CoA carboxylase activity, exerts citrate-competitive inhibitory effects on ATP-citrate lyase, and reduces hepatic AMPK activity. MEDICA16 can be used in research related to insulin resistance, hyperlipidemia, and obesity .

HY-15259A

CP-640186 hydrochloride 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 hydrochloride is an orally active and cell-permeable **Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀*s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase* (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation .

HY-135981

CMS-121 2 Publications Verification	Acetyl-CoA Carboxylase	Neurological Disease Inflammation/Immunology
CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC₅₀ values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities .

HY-147004

A-908292	Acetyl-CoA Carboxylase	Metabolic Disease
A-908292 is a potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC₅₀ of 23 nM for human ACC2. A-908292 can be used for the research of fatty acid metabolism . A-908292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-107709

MK-4074 4 Publications Verification	Acetyl-CoA Carboxylase	Metabolic Disease
MK-4074 is a liver-specific inhibitor of **acetyl-CoA carboxylase ACC1 and ACC2 with IC₅₀** values of approximately 3 nM.

HY-114591

Spiromesifen BSN 2060	Environmental Pollutants Drug Derivative Acetyl-CoA Carboxylase	Infection
Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen reduces lipid biosynthesis via inhibition of **acetyl-CoA carboxylase**, and has no cross-resistance to any resistant mite or whitefly populations .

HY-W612338

9-Oxononanoic acid 9-ONA	Acetyl-CoA Carboxylase	Inflammation/Immunology
9-Oxononanoic acid (9-ONA) is an orally active **acetyl-CoA carboxylase inhibitor. 9-Oxononanoic acid inhibits acetyl-CoA carboxylase via accumulation of long-chain acyl-CoA. 9-Oxononanoic acid increases carnitine palmitoyltransferase, isocitrate dehydrogenase and glucose 6-phosphate dehydrogenase activity to elevate β-oxidation and support NADPH (HY-113324) supplyactivity. 9-Oxononanoic acid stimulates phospholipase A2** activity via post-translational, non-transcriptional mechanisms. 9-Oxononanoic acid can be used for the research of atherothrombosis .

HY-N14257

Andrimid	Bacterial Antibiotic Acetyl-CoA Carboxylase	Infection
Andrimid is a peptide Antibiotic and **acetyl-CoA carboxylase** inhibitor. Andrimid is produced by symbiotic bacteria of the genus Enterobacter residing in the brown planthopper Nilaparvata lugens. Andrimid exhibits strong specific activity against Xanthomonas campestris pv. oryzae. Andrimid shows no or only weak activity against Gram-positive and Gram-negative bacteria, including most plant pathogenic bacteria. Andrimid can be used in studies related to bacterial infections and rice bacterial blight .

HY-117262

Propaquizafop	Acetyl-CoA Carboxylase	Others
Propaquizafop is a phenoxyisopropionic acid herbicide and an **acetyl-coA carboxylase** inhibitor .

HY-147376

hACC2-IN-1	Acetyl-CoA Carboxylase	Metabolic Disease
hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC₅₀ value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research .

HY-W588256

12-Tridecenoic acid	Endogenous Metabolite Acetyl-CoA Carboxylase	Infection
12-Tridecenoic acid is a metabolite of intestinal flora, which can promote the expression of acetyl-CoA carboxylase α (ACC) and inhibit the expression of carnitine palmitoyltransferase 1A (CPT1A), thereby aggravating hepatic steatosis. 12-Tridecenoic acid aggravates hepatic steatosis by affecting the ACC-CPT1A axis .

HY-179537

CKBA	Acetyl-CoA Carboxylase Drug Derivative	Inflammation/Immunology
CKBA, a derivative of AKBA (HY-N0892) is an inhibitor of acetyl-CoA carboxylase 1 (ACC1), with an IC₅₀ of 5.02 μM. CKBA inhibits the differentiation of Th17 cells and has IC₅₀ values of 3.28 μM for mouse cells and 3.61 μM for human cells. CKBA ointment significantly alleviates psoriasis-like inflammation in mice. CKBA can be used for the study of psoriasis .

HY-P11358

IRW	Angiotensin-converting Enzyme (ACE) Acetyl-CoA Carboxylase Mitochondrial Metabolism	Inflammation/Immunology
IRW is an orally active tripeptide produced from egg white with angiotensin converting enzyme (ACE) inhibitory properties. IRW can prevent high-fat diet (HFD)-induced Non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and increasing mitochondrial content. IRW decreases hepatic triglyceride content and lipid droplet size. IRW increases the hepatic mitochondrial complexes and citrate synthase activity, phosphorylation of 5’-AMP-activated protein kinase and microsomal triglyceride transfer protein abundance. IRW increases phosphorylated **acetyl CoA carboxylase** and mitochondrial complexes, IRW can be used for the research of inflammation .

HY-16943

Moiramide B	Bacterial Acetyl-CoA Carboxylase	Infection
Moiramide B is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC₅₀ value of 6 nM. Moiramide B has antibacterial activity .

HY-123307

Quizalofop Xylafop	Environmental Pollutants Acetyl-CoA Carboxylase	Others
Quizalofop (Xylafop) is a herbicide that inhibits acetyl-CoA carboxylase (ACCase) to reduce the synthesis of fatty acids. Quizalofop can be used to screen EMS (HY-W015854) mutated microalgae for research on improving the performance of microalgae biofuel production .

HY-127108

ND-654	Acetyl-CoA Carboxylase	Metabolic Disease Cancer
ND-654 is a highly selective acetyl-CoA carboxylase (ACC) inhibitor (IC₅₀: ACC1=3 nM, ACC2=8 nM). ND-654 reduces hepatic lipogenesis, decreases neutrophil recruitment and promotes anti-inflammatory M2 macrophage polarization. ND-654 is promising for research of nonalcoholic steatohepatitis and hepatocellular carcinoma .

HY-150191

IMA-1	Lipoxygenase Acetyl-CoA Carboxylase	Metabolic Disease
IMA-1 is an inhibitor that inhibits the interaction between arachidonic acid 12-lipoxygenase (ALOX12) and acetyl-CoA carboxylase 1 (ACC1). IMA-1 significantly blocks the progression of diet-induced non-alcoholic steatohepatitis (NASH) in male mice and crab-eating monkeys, and does not cause hyperlipidemia. IMA-1 can be used for the study of NASH .

HY-178040

Insecticidal agent 26	Acetyl-CoA Carboxylase Pyruvate Carboxylase (PC) Parasite Insecticide	Infection
Insecticidal agent 26 (Compound A11), a spiro insecticidal agent, is a dual-functional inhibitor of pest Acetyl-CoA carboxylase (ACC) and *Pyruvate carboxylase* (PC)*. Insecticidal agent 26 has potent insecticidal activity against Sogatella furcifera* with a LC₅₀ of 11.0  μg/mL, with significant biosafety to bees. Insecticidal agent 26 can be used for management of white-backed planthoppers (WBPs) .

HY-16901A

Firsocostat (S enantiomer) ND-630 (S enantiomer); GS-0976 (S enantiomer); NDI-010976 (S enantiomer)	Acetyl-CoA Carboxylase	Others
Firsocostat S enantiomer (ND-630 S enantiomer) is the less active S enantiomer of Firsocostat. Firsocostat is an acetyl-CoA carboxylase (ACC) inhibitor.

HY-114575

Cycloxydim BAS 517-02H	Herbicide Acetyl-CoA Carboxylase	Others
Cycloxydim (BAS 517-02H) is a cyclohexanedione oxime herbicide. Cycloxydim can inhibits the **acetyl-CoA carboxylase** .

HY-169009

(Rac)-Spirotetramat-enol	Acetyl-CoA Carboxylase	Infection
(Rac)-Spirotetramat-enol (Compound 8) is a ligand of acetyl-CoA carboxylase that can be used to synthesize PROTAC ADC degrader (HY-169008) .

HY-121273

Diclofop Dichlorfop acid; (±)-Diclofop	Acetyl-CoA Carboxylase Parasite Drug Metabolite	Infection
Diclofop (Dichlorfop acid) is an acetyl-CoA carboxylase (ACC) inhibitor. Diclofop is also the major metabolite of the herbicide Diclofop-methyl (HY-136367). Diclofop exhibits antimalarial activity with an IC₅₀ of 210 μM against P. falciparum .

HY-173565

ACC-IN-1	Acetyl-CoA Carboxylase	Inflammation/Immunology
ACC-IN-1 (Compound B1) is an allosteric inhibitor of acetyl-CoA carboxylase (ACC). ACC-IN-1 targets ACC to regulate lipid metabolism, which can improve liver steatosis, inflammation related to non-alcoholic steatohepatitis (NASH) .

HY-16946

CP-610431	Acetyl-CoA Carboxylase	Metabolic Disease
CP-610431 is a reversible, ATP-uncompetitive, isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor. CP-610431 inhibits ACC1 and ACC2 with IC₅₀s of ~50 nM. CP-610431 can be used for the research of metabolic syndrome .

HY-139134

S-2E	HMG-CoA Reductase (HMGCR) Acetyl-CoA Carboxylase	Cardiovascular Disease
S-2E is an orally active and noncompetitive HMG-CoA reductase and **acetyl-CoA carboxylase** inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research .

HY-16901R

Firsocostat (Standard) ND-630 (Standard); GS-0976 (Standard); NDI-010976 (Standard)	Acetyl-CoA Carboxylase Reference Standards	Metabolic Disease
Firsocostat (Standard) is the analytical standard of Firsocostat. This product is intended for research and analytical applications. Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively.

HY-N0468R

Rebaudioside D (Standard)	Reference Standards Acetyl-CoA Carboxylase FXR	Metabolic Disease
Rebaudioside D (Standard) is the analytical standard of Rebaudioside D. This product is intended for research and analytical applications. Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates **Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase**. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research .

HY-111223

Tralkoxydim PP604; ICIA 0604; FD-4026	Acetyl-CoA Carboxylase	Others
Tralkoxydim is a cyclohexanedione herbicide that inhibits Acetyl-CoA Carboxylase in corn .

HY-W747605

Tepraloxydim	Acetyl-CoA Carboxylase Herbicide	Others
Tepraloxydim is an **acetyl-CoA carboxylase** inhibitor with weed control activity .

HY-121427

Fluazifop	Acetyl-CoA Carboxylase	Others
Fluazifop is a grass-selective herbicide via inhibiting acetyl-CoA carboxylase .

HY-161976

ACC1-IN-2	Acetyl-CoA Carboxylase	Inflammation/Immunology
ACC1-IN-2 (Compound 16) is an ACC1 inhibitor with an IC₅₀ of 7.3 nM. ACC1-IN-2 can be used in the study of acne .

HY-111223R

Tralkoxydim (Standard) PP604 (Standard); ICIA 0604 (Standard); FD-4026 (Standard)	Acetyl-CoA Carboxylase Reference Standards	Others
Tralkoxydim (Standard) is the analytical standard of Tralkoxydim. This product is intended for research and analytical applications. Tralkoxydim is a cyclohexanedione herbicide that inhibits Acetyl-CoA Carboxylase in corn .

HY-117262R

Propaquizafop (Standard)	Reference Standards Acetyl-CoA Carboxylase	Others
Propaquizafop (Standard) is the analytical standard of Propaquizafop. This product is intended for research and analytical applications. Propaquizafop is a phenoxyisopropionic acid herbicide and an acetyl-coA carboxylase inhibitor .

HY-N7007R

Sclareol glycol (Standard)	Drug Intermediate Reference Standards	Metabolic Disease
Fluazifop (Standard) is the analytical standard of Fluazifop. This product is intended for research and analytical applications. Fluazifop is a grass-selective herbicide via inhibiting acetyl-CoA carboxylase .

HY-121427R

Fluazifop (Standard)	Reference Standards Acetyl-CoA Carboxylase	Others
Fluazifop (Standard) is the analytical standard of Fluazifop. This product is intended for research and analytical applications. Fluazifop is a grass-selective herbicide via inhibiting acetyl-CoA carboxylase .

HY-114591R

Spiromesifen (Standard) BSN 2060 (Standard)	Acetyl-CoA Carboxylase Reference Standards	Infection
Spiromesifen (Standard) is the analytical standard of Spiromesifen. Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen reduces lipid biosynthesis via inhibition of **acetyl-CoA carboxylase**, and has no cross-resistance to any resistant mite or whitefly populations .

HY-169008

PROTAC ACC degrader-1	PROTACs Acetyl-CoA Carboxylase	Infection
PROTAC ACC degrader-1 (Compound 9b) is a **Acetyl-CoA Carboxylase** degrader. PROTAC ACC degrader-1 exhibits superior potency against Aphis craccivora (IC₅₀ = 107.8 μg/mL). (Structure Note: Pink, Target protein ligand (HY-169009); Blue, E3 ligand (HY-10984); Black, linker (HY-W007559) .

HY-170931

AMPK activator 16	AMPK Acetyl-CoA Carboxylase	Neurological Disease Metabolic Disease
AMPK activator 16 (compound 6) is a AMP-activated protein kinase (AMPK) inhibitor. AMPK activator 16 shows the most efficient interactions with the key residues of AMPK and demonstrates significant activation of AMPK. AMPK activator 16 increases the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) (p-ACC) and phosphorylated raptor (p-raptor), in N2a cells .

HY-121427S

Fluazifop-d3	Isotope-Labeled Compounds Acetyl-CoA Carboxylase	Others
Fluazifop-d₃ is the deuterium labeled Fluazifop (HY-121427). Fluazifop is a grass-selective herbicide via inhibiting acetyl-CoA carboxylase .

Cat. No.	Product Name

HY-L091

Lipid Metabolism Compound Library

978 compounds

Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes, and based on this can be broadly classified into five categories: fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids and sphingolipids. Lipids play a crucial role in different metabolic pathways and cellular functions. Lipid metabolism is an important physiological process that is related to nutrient adjustment, hormone regulation, and homeostasis. Lipid metabolism dysregulation is associated with many diseases such as obesity, liver disease, aging and inflammation.

MCE offers a unique collection of 978 compounds related to lipid metabolism, which target relevant targets in the process of lipid metabolism, such as ATGL, MAGL, FAAH, acetyl-Coa Carboxylase, FASN, etc. MCE lipid metabolism compound library is a useful tool for research lipid metabolism and drug discovery of diseases related to lipid metabolism.

Cat. No.	Product Name	Target	Research Area

HY-P11358

IRW	Angiotensin-converting Enzyme (ACE) Acetyl-CoA Carboxylase Mitochondrial Metabolism	Inflammation/Immunology
IRW is an orally active tripeptide produced from egg white with angiotensin converting enzyme (ACE) inhibitory properties. IRW can prevent high-fat diet (HFD)-induced Non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and increasing mitochondrial content. IRW decreases hepatic triglyceride content and lipid droplet size. IRW increases the hepatic mitochondrial complexes and citrate synthase activity, phosphorylation of 5’-AMP-activated protein kinase and microsomal triglyceride transfer protein abundance. IRW increases phosphorylated **acetyl CoA carboxylase** and mitochondrial complexes, IRW can be used for the research of inflammation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 650 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Disease Research Fields Source Classification	Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-15142R

Doxorubicin hydrochloride (Standard) 5 Publications Verification Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard)	Quinones Structural Classification Microorganisms Anthraquinones Source Classification	Reference Standards Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye
Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-15142A

Doxorubicin Hydroxydaunorubicin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Phenols Polyphenols Disease Research Fields Source Classification	ADC Payload Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV Fluorescent Dye
Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy .

HY-N0468

Rebaudioside D 1 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Metabolic Disease Diterpenoids Plants Disease Research Fields Sweeteners Source Classification Food Research	FXR Acetyl-CoA Carboxylase
Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates **Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase**. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research .

HY-W612338

9-Oxononanoic acid 9-ONA	Structural Classification Arachis hypogaea L. Leguminosae Ketones, Aldehydes, Acids Plants Source Classification	Acetyl-CoA Carboxylase
9-Oxononanoic acid (9-ONA) is an orally active **acetyl-CoA carboxylase inhibitor. 9-Oxononanoic acid inhibits acetyl-CoA carboxylase via accumulation of long-chain acyl-CoA. 9-Oxononanoic acid increases carnitine palmitoyltransferase, isocitrate dehydrogenase and glucose 6-phosphate dehydrogenase activity to elevate β-oxidation and support NADPH (HY-113324) supplyactivity. 9-Oxononanoic acid stimulates phospholipase A2** activity via post-translational, non-transcriptional mechanisms. 9-Oxononanoic acid can be used for the research of atherothrombosis .

HY-N14257

Andrimid	Structural Classification Natural Products Microorganisms Source Classification	Bacterial Antibiotic Acetyl-CoA Carboxylase
Andrimid is a peptide Antibiotic and **acetyl-CoA carboxylase** inhibitor. Andrimid is produced by symbiotic bacteria of the genus Enterobacter residing in the brown planthopper Nilaparvata lugens. Andrimid exhibits strong specific activity against Xanthomonas campestris pv. oryzae. Andrimid shows no or only weak activity against Gram-positive and Gram-negative bacteria, including most plant pathogenic bacteria. Andrimid can be used in studies related to bacterial infections and rice bacterial blight .

HY-16943

Moiramide B	Microorganisms Source Classification	Bacterial Acetyl-CoA Carboxylase
Moiramide B is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC₅₀ value of 6 nM. Moiramide B has antibacterial activity .

HY-N0468R

Rebaudioside D (Standard)	Structural Classification other families Terpenoids Diterpenoids Plants Source Classification	Reference Standards Acetyl-CoA Carboxylase FXR
Rebaudioside D (Standard) is the analytical standard of Rebaudioside D. This product is intended for research and analytical applications. Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates **Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase**. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research .

HY-N7007R

Sclareol glycol (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Drug Intermediate Reference Standards
Fluazifop (Standard) is the analytical standard of Fluazifop. This product is intended for research and analytical applications. Fluazifop is a grass-selective herbicide via inhibiting acetyl-CoA carboxylase .

Species:	E.coli (1)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702154

	birA Protein, E. coli (His) birA; Bifunctional ligase/repressor BirA; Biotin operon repressor; Biotin--[Acetyl-CoA-Carboxylase] ligase; Biotin--protein ligase; Biotin-[Acetyl-CoA Carboxylase] synthetase	E.coli	E. coli
	The birA protein has the dual role of biotin ligase and biotin operon repressor. In the presence of ATP, it activates biotin to form the BirA-biotinyl-5'-adenylate complex. birA Protein, E. coli (His) is the recombinant E. coli-derived birA protein, expressed by E. coli , with N-6*His labeled tag.

HY-P703428

	birA Protein, B. subtilis (His) Bifunctional ligase/repressor BirA; Biotin--[Acetyl-CoA-Carboxylase] ligase; 6.3.4.15; Biotin--protein ligase; Biotin-[Acetyl-CoA Carboxylase] synthetase; birA; Bacillus subtilis (strain 168); DNA-binding; Ligase; Repressor	Others	E. coli
	birA Protein, B. subtilis (His) is the recombinant birA protein, expressed by E. coli, with His tag.

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Cat. No.	Product Name	Chemical Structure

HY-121427S

Fluazifop-d3
Fluazifop-d₃ is the deuterium labeled Fluazifop (HY-121427). Fluazifop is a grass-selective herbicide via inhibiting acetyl-CoA carboxylase .

Host:	Mouse (1) Rabbit (14)
Reactivity:	Human (15) Rat (8) Mouse (7)
Application:	IHC-P (6) ICC/IF (5) IP (6) WB (15) FC (1) ELISA (1)
Isotype:	IgG (13) IgG, IgG/Kappa (1)
Conjugation:	Non-conjugated (15)
Clonality:	Polyclonal (3) Monoclonal (7) Recombinant (4)
Modification:	Phosphorylated (4) Unmodified (6)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80482

	Acetyl CoA Carboxylase 1 (ACC1) Antibody (YA646) 1 Publications Verification	WB, IHC-P	Human, Mouse
	Acetyl CoA Carboxylase 1 (ACC1) Antibody (YA646) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Acetyl CoA Carboxylase 1 (ACC1).

HY-P80787

	*Phospho-Acetyl* Coenzyme A Carboxylase (Ser79) Antibody (YA229)** ACACA; ACAC; ACC1; ACCA; Acetyl-CoA Carboxylase 1; ACC1; ACC-alpha	WB	Human, Mouse, Rat
	Phospho-Acetyl Coenzyme A Carboxylase (Ser79) Antibody (YA229) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Acetyl Coenzyme A Carboxylase (Ser79).

HY-P810548

	*Phospho-Acetyl* Coenzyme A Carboxylase (Ser79) Antibody (YA9817)** ACACA; ACAC; ACC1; ACCA; Acetyl-CoA Carboxylase 1; ACC1; ACC-alpha	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Phospho-Acetyl Coenzyme A Carboxylase (Ser79) Antibody (YA9817) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-Acetyl Coenzyme A Carboxylase (Ser79).

HY-P86324

	Acetyl Coenzyme A Carboxylase Antibody (YA6016) ACACB,Acetyl CoA Carboxylase 2,ACC beta,ACC2,ACCB,AcetylCoA Carboxylase 2,ACCbeta,ACCβ,ACC β,	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Acetyl Coenzyme A Carboxylase Antibody (YA6016) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Acetyl Coenzyme A Carboxylase.

HY-P80787A

	*Phospho-Acetyl* Coenzyme A Carboxylase (Ser79) Antibody (YA229)(PBS only)** ACACA; ACAC; ACC1; ACCA; Acetyl-CoA Carboxylase 1; ACC1; ACC-alpha	WB	Human
	Phospho-Acetyl Coenzyme A Carboxylase (Ser79) Antibody (YA229) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Acetyl Coenzyme A Carboxylase (Ser79).

HY-P80541

	AMPK alpha 2 Antibody (YA622) 2 Publications Verification PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA Carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB, IP	Human
	AMPK alpha 2 Antibody (YA622) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMPK alpha 2.

HY-P80791

	Phospho-AMPK alpha 2 (Thr172) Antibody 1 Publications Verification PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA Carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB	Human, Mouse, Rat
	Phospho-AMPK alpha 2 (Thr172) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-AMPK alpha 2 (Thr172).

HY-P80540

	AMPK alpha 2 Antibody (YA623) PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA Carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB, IP	Human, Rat
	AMPK alpha 2 Antibody (YA623) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMPK alpha 2.

HY-P80539

	AMPK alpha 1 Antibody PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA Carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	AMPK alpha 1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to AMPK alpha 1.

HY-P80791A

	Phospho-AMPK alpha 2 (Thr172) Antibody(YA9953) PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA Carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB	Human, Mouse, Rat
	Phospho-AMPK alpha 2 (Thr172) Antibody is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-AMPK alpha 2 (Thr172).

HY-P80540A

	AMPK alpha 2 Antibody (YA623)(PBS only) PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA Carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB, IP	Human, Rat
	AMPK alpha 2 Antibody (YA623) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMPK alpha 2.

HY-P80541A

	AMPK alpha 2 Antibody (YA622)(PBS only) PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA Carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB, IP	Human
	AMPK alpha 2 Antibody (YA622) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMPK alpha 2.

HY-P810580

	Phospho-AMPK alpha 2 (Ser491) Antibody (YA9844) PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA Carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase	WB	Human
	Phospho-AMPK alpha 2 (Ser491) Antibody (YA9844) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-AMPK alpha 2 (Ser491).

HY-P85745

	AMPK alpha 1 Antibody (YA5437) PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA Carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1	WB, IHC-P, ICC/IF	Human
	AMPK alpha 1 Antibody (YA5437) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to AMPK alpha 1.

HY-P80790

	Phospho-AMPK alpha 1 (Ser496) Antibody PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA Carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1	WB, IHC-P, ICC/IF	Human
	Phospho-AMPK alpha 1 (Ser496) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-AMPK alpha 1 (Ser496).