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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
Adriamycin hydrochloride
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "Adriamycin hydrochloride" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-121309
CAS No.: 24385-10-2
Synonyms: Adriamycin aglycone; Adriamycinone
Category:
Infection Quinones Anthraquinones Phenols Polyphenols Plants Solanaceae Disease Research Fields Rhizophora mucronata Lam
Target:
Cat. No.: HY-121309R
CAS No.: 24385-10-2
Synonyms: Adriamycin aglycone (Standard); Adriamycinone (Standard)
Category:
Cat. No.: HY-144774
CAS No.: 2513461-95-3
Target:
Research Areas:
Topoisomerase I inhibitor 5 is an effective topoisomerase inhibitor with IC50 value of. Topoisomerase I inhibitor 5 can interfere with DNA and significantly inhibit the activity of Topoisomerase I. Topoisomerase I inhibitor 5 can arrest cell cycle at the G1 phase and induce MCF-7 cells apoptosis. Topoisomerase I inhibitor 5 has potency in reversing P-gp-mediated resistance to Adriamycin .
Cat. No.: HY-176421
CAS No.: 3070438-85-3
Target:
PROTACs PI3K Apoptosis Akt Bcl-2 Family Caspase P-glycoprotein
Research Areas:
PROTAC PI3K/110β degrader-1 is a VHL-recruiting PROTAC degrader targeting PI3K/110β, with DC50 values of 0.416 μM (MCF-7) and 19.66 μM (A549), respectively. PROTAC PI3K/110β degrader-1 recruits VHL to induce proteasomal degradation of PI3K/110β. It activates endoplasmic reticulum stress (ERS)-mediated mitochondrial apoptosis via the PERK/ATF4/CHOP unfolded protein response (UPR) pathway, downregulates p-AKT and Bcl-2, upregulates Bax, cleaved-caspase-9 and cleaved-caspase-3, inhibits the expression and activity of P-gp, and exerts synergistic anti-tumor effects with Doxorubicin (Adriamycin, ADM) (HY-15142A) and Cisplatin (DDP) (HY-17394). PROTAC PI3K/110β degrader-1 can be used in research related to multidrug-resistant cancers .
Cat. No.: HY-113771
CAS No.: 99260-70-5
Category:
Target:
Cat. No.: HY-N13868
CAS No.: 99260-69-2
Category:
Target:
Cat. No.: HY-N13870
CAS No.: 99260-66-9
Category:
Target:
Cat. No.: HY-151165R
CAS No.: 2810894-92-7
Target:
Research Areas:
Quinizarin (Standard) is the analytical standard of Quinizarin. This product is intended for research and analytical applications. Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth .
Cat. No.: HY-117285
CAS No.: 60227-09-0
Synonyms: Lactoquinomycin A; LQM-A
Category:
Target:
Cat. No.: HY-N14774
CAS No.: 101342-94-3
Category:
Target:
Cat. No.: HY-126802
CAS No.: 99260-68-1
Category:
Target:
Cat. No.: HY-N17419
CAS No.: 790234-59-2
Target:
Cat. No.: HY-106326
CAS No.: 116521-53-0
Synonyms: FAD 104
ME 2303 (FAD 104) is a fluoro-pyranosyl adriamycin analogue with anti-tumor potential. ME 2303 can inhibit the proliferation of acute undifferentiated myeloblastic leukemia (AML) blast cells in a dose-dependent manner. ME 2303 can be used for the study of acute undifferentiated myeloblastic leukemia (AML) .
Cat. No.: HY-181556
CAS No.: 3085181-00-3
Target:
Research Areas:
JNK3-IN-10 is a blood-brain barrier-impermeable JNK3 inhibitor (IC50=0.257 nM) with over 400-fold selectivity over JNK1. JNK3-IN-10 blocks the JNK3-mediated signaling pathway downstream of TGF-β1, inhibits TGF-β1-induced phosphorylation of c-Jun, reduces the expression of pro-fibrotic markers, and restores the expression of the epithelial protein E-cadherin. JNK3-IN-10 exhibits low cytotoxicity, anti-fibrotic, cytoprotective and renoprotective effects, and alleviates albuminuria, glomerulosclerosis and podocyte foot process fusion. JNK3-IN-10 can be used for the research of chronic kidney disease, glomerulosclerosis and adriamycin-induced nephropathy .
Cat. No.: HY-183480
CAS No.: 80841-47-0
Synonyms: CI-921; NSC 343499
Target:
Research Areas:
Asulacrine (CI-921) is an orally active DNA intercalating topoisomerase II inhibitor. Asulacrine binds to DNA via intercalation, with its acridine chromophore intercalated between base pairs and substituents located in the major/minor grooves, which stabilizes DNA against acid denaturation. Asulacrine acts as a cell cycle inhibitor, disruptor, and arrest inducer, slowing cell progression in late S/G2 phase, causing G2 phase arrest and inducing unbalanced growth. Asulacrine inhibits cell growth, clonogenicity, and colony formation, and leads to histological destruction of tumor cells. Compared to cells in exponential growth phase, Asulacrine exhibits lower toxicity to quiescent cells; its activity depends on cationic properties, and it has better water solubility and metabolic stability. Asulacrine can be used in research related to leukemia, lung cancer, colon cancer, breast cancer, melanoma, adriamycin-resistant mammary adenocarcinoma, and mouse solid tumors .
Cat. No.: HY-P74654
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PAK3; HPAK3; Prev. MRX30; PAK-3; Prev. MRX47; Adriamycin Resistance-Associated; BPAK; Mental Retardation, X-Linked 47; P21 Protein (Cdc42/Rac)-Activated Kinase 3; P21-Activated Kinase 3; Serine/Threonine-Protein Kinase PAK 3; PAK3beta; P21 (CDKN1A)-Activa
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702746
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PAK3; HPAK3; Prev. MRX30; PAK-3; Prev. MRX47; Adriamycin Resistance-Associated; BPAK; Mental Retardation, X-Linked 47; P21 Protein (Cdc42/Rac)-Activated Kinase 3; P21-Activated Kinase 3; Serine/Threonine-Protein Kinase PAK 3; PAK3beta; P21 (CDKN1A)-Activa
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705853
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PAK3; HPAK3; Prev. MRX30; PAK-3; Prev. MRX47; Adriamycin Resistance-Associated; BPAK; Mental Retardation, X-Linked 47; P21 Protein (Cdc42/Rac)-Activated Kinase 3; P21-Activated Kinase 3; Serine/Threonine-Protein Kinase PAK 3; PAK3beta; P21 (CDKN1A)-Activa
Species:
Human
Source:
sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
