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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
76 Results for "
Antileishmanial agent
" in MedChemExpress (MCE) Product Catalog:
Products (76)
76 Results for "Antileishmanial agent" in MCE Product Catalog:
15
15 Cited Publications
Synonyms: HePC; Hexadecyl phosphocholine
Research Areas:
Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .
1
1 Cited Publications
Cat. No.: HY-W015818
CAS No.: 59-49-4
Synonyms: 2-Benzoxazolone; 1,3-Benzoxazol-2(3H)-one; 2-Hydroxybenzoxazole
Category:
Infection Alkaloids Other Alkaloids Gramineae Secale cereale Plants Disease Research Fields
Target:
Cat. No.: HY-W012634
CAS No.: 95-16-9
Target:
Cat. No.: HY-W077028
CAS No.: 21442-01-3
Target:
Research Areas:
N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) .
1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .
Category:
Rutaceae Plants Indole Alkaloids Infection Alkaloids Monophenols Murraya koenigii (L.) Spreng Phenols Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-W075770
CAS No.: 1313-99-1
Synonyms: Nickel monoxide
Target:
Environmental Pollutants Apoptosis Reactive Oxygen Species (ROS) Caspase TGF-beta/Smad p38 MAPK Akt PI3K
Research Areas:
Nickel(II) oxide (nickel monoxide) is a chemical warfare agent that can enter the body through the respiratory tract and other routes, distributing to organs such as the lungs and testes. The nanoparticle form of nickel(II) oxide (NiO NPs) exhibits antibacterial, anti-leishmanial, anti-diabetic, and anti-cancer activities. NiO NPs can be activated by ultraviolet and visible light, generating reactive oxygen species (ROS). Nickel(II) oxide induces oxidative stress by generating reactive oxygen species, activating the TGF-β1-mediated MAPK and PI3K/AKT pathways, disrupting the MMPs/TIMPs balance, and upregulating the expression of inflammatory factors (IL-1β, IL-6) and apoptosis-related molecules (Bax, caspase-3, p53), while inhibiting the activity of the anti-apoptotic molecule Bcl-2. Nickel(II) oxide induces cytotoxicity, promotes fibrosis, triggers inflammatory responses, and causes apoptosis. Nickel(II) oxide can be applied in research on the safety assessment of nanomaterials, such as in the context of pulmonary fibrosis and reproductive system toxicity .
Cat. No.: HY-155520
CAS No.: 3049715-81-0
Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC50 of 3.39 μM for L. donovani promastigotes. Antileishmanial agent-19 inhibits Leishmania prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani promastigotes. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals .
Cat. No.: HY-134467
CAS No.: 98570-83-3
Target:
Cat. No.: HY-151935
CAS No.: 853725-86-7
Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively .
Cat. No.: HY-149958
CAS No.: 2934738-40-4
Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
Cat. No.: HY-155301
CAS No.: 2999670-36-7
Antileishmanial agent-24 (compound 33) is an antileishmanial agent with an IC50 of 5.39 μM against amastigote .
Cat. No.: HY-W631668
CAS No.: 139276-16-7
Antileishmanial agent-34 (Fig. (9), compound 3) is an aurone with antileishmanial activity. Antileishmanial agent-34 against extracellular forms of Lmaj, Ldon, Linf and Lenr as well as against intracellular forms of Ldon (IC50 of <2 µg/mL) .
Cat. No.: HY-13685R
CAS No.: 58066-85-6
Synonyms: HePC (Standard); Hexadecyl phosphocholine (Standard)
Miltefosine (Standard) is the analytical standard of Miltefosine. This product is intended for research and analytical applications. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .
Cat. No.: HY-146744
CAS No.: 2922333-23-9
Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent .
Cat. No.: HY-146745
CAS No.: 2922333-29-5
Target:
Research Areas:
Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent. Antileishmanial agent-4 is against L.infantum and T.cruzi with EC50 values of 0.68 μM and 0.83 μM, respectively .
Cat. No.: HY-133101
CAS No.: 1031727-34-0
Synonyms: 14-Norpseurotin
Category:
Cat. No.: HY-147535
CAS No.: 503323-06-6
Antileishmanial agent-7 (compound 23) is a potent antileishmanial agent. Antileishmanial agent-7 shows antileishmanial activity against Leishmania donovani and L-6, with IC50 values of 6.89 and 259 μM, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
